Employee preferences for industry retention strategies : the case of Macau’s “Golden Nest Eggs”

202206 bckwAccepted ManuscriptSelf-fundedPublishe

Training hotels in Asia : an exploration of alternative models

202206 bckwAccepted ManuscriptOthersUniversidade de MacauPublishe

The journey from episodes to evaluations : how travelers arrive at summary evaluations

202206 bckwAccepted ManuscriptOthersUniversity of Macau; Higher Education FundPublishe

Estimating future room occupancy fluctuations to optimize hotel revenues

2015-2016 > Academic research: refereed > Publication in refereed journalAccepted ManuscriptPublishe

Highly selective and sensitive macrocycle-based dinuclear foldamer for fluorometric and colorimetric sensing of citrate in water

Abstract The selective detection of citrate anions is essential for various biological functions in living systems. A quantitative assessment of citrate is required for the diagnosis of various diseases in the human body; however, it is extremely challenging to develop efficient fluorescence and color-detecting molecular probes for sensing citrate in water. Herein, we report a macrocycle-based dinuclear foldamer (1) assembled with eosin Y (EY) that has been studied for anion binding by fluorescence and colorimetric techniques in water at neutral pH. Results from the fluorescence titrations reveal that the 1·EY ensemble strongly binds citrate anions, showing remarkable selectivity over a wide range of inorganic and carboxylate anions. The addition of citrate anions to the 1·EY adduct led to a large fluorescence enhancement, displaying a detectable color change under both visible and UV light in water up to 2 μmol. The biocompatibility of 1·EY as an intracellular carrier in a biological system was evaluated on primary human foreskin fibroblast (HF) cells, showing an excellent cell viability. The strong binding properties of the ensemble allow it to be used as a highly sensitive, detective probe for biologically relevant citrate anions in various applications