Rapid recurrence of a malignant meningioma: Case report

This short report presents a case that developed rapid recurrence of a malignant meningioma. The meningioma was located on the right temporal lobe and total removal (Simpson grade-II) was performed. Radiotherapy was not given and the lesion recurred within four months. The MIB-1 (Ki-67) index was 30 % and the tumor fulfilled all the criteria of anaplasia. After the second surgery, patient was transferred to the Radiation Oncology for radiotherapy. Should we questioned the extent of surgery? Neurosurgeons should be careful and close follow-up the patients with malignant meningioma

Diagnostic value of preoperative systemic inflammatory markers in patients with intracranial meningiomas

Introduction: The role of inflammation in cancer has been defined, and now, inflammation is accepted as one of the hallmarks of cancer development. The aim of this study was to evaluate the difference regarding preoperative neutrophil to lymphocyte (NLR) and platelet to lymphocyte ratios (PLR) in patients with meningioma between patients and healthy controls and between grade-I and grade-II meningiomas. Methods: Retrospective analysis of preoperative neutrophil, lymphocyte, monocyte, and platelet counts and NLR, and PLR were evaluated in 61 patients underwent meningioma surgery. Results: Neutrophil count was significantly increased while lymphocyte count significantly decreased patients compared to controls. Similar findings were obtained in grade-II meningiomas compared with grade-I meningiomas. NLR were significantly higher in both grade-I and grade-II meningiomas than controls. Conclusion: We for the first time provided that higher NLR may be associated with grading of meningioma and be a predictive factor for progression of meningiomas. The use of medication against neutrophil-related inflammation may be helpful for patients with higher grade of meningioma decreasing peritumoral edema before and after surgery

Risk factors for preoperative and postoperative late seizure in supratentorial meningiomas: A retrospective analysis of 63 patients

Introduction. Seizure following meningioma surgery is common and management may be challenging. Identifying risk factors may help physicians to initiate optimal medical management. The aim of this study is to report seizure outcome and risk factors for perioperative seizure. Materials and Methods. Sixty-three adult patients who underwent supratentorial meningioma resection were included, and perioperative data and long-term follow-up were provided in this retrospective study. Binary logistic regression analysis was used to identify the risk factors for perioperative seizure and postoperative late seizure. Results. The results showed that 20 (37.1 %) patients had preoperative seizure and 10 (50 %) patients were seizure free at the long-term follow-up. Absence of headache was associated with preoperative seizure (p=0.002) while presence of early seizure was significant predictor for postoperative late seizure (p=0.03). Although not significant, occurrence of surgical complications (p=0.08) and non-skull base location (p=0.06) tended toward being a significant risk factor for postoperative late seizure. Conclusion. Presence of early seizures, surgical complications and locations out of skull base may direct postoperative anti-epileptic treatment to decrease seizure incidence which, indeed, increases quality of life for patients with meningioma