The Euler characteristic of an enriched category

We define Euler characteristic of a category enriched by a monoidal model category. If a monoidal model category V is equipped with Euler characteristic that is compatible with weak equivalences and fibrations in V, then our Euler characteristic is also compatible with weak equivalences and fibrations in the model structure induced by that of V. In particular, we focus on the case of topological categories; that is, categories enriched by the category of topological spaces. As its application, we obtain the ordinary Euler characteristic of a cellular stratified space X by computing the Euler characteristic of the face category C(X) induced from X

Capacity and Modulations with Peak Power Constraint

A practical communication channel often suffers from constraints on input other than the average power, such as the peak power constraint. In order to compare achievable rates with different constellations as well as the channel capacity under such constraints, it is crucial to take these constraints into consideration properly. In this paper, we propose a direct approach to compare the achievable rates of practical input constellations and the capacity under such constraints. As an example, we study the discrete-time complex-valued additive white Gaussian noise (AWGN) channel and compare the capacity under the peak power constraint with the achievable rates of phase shift keying (PSK) and quadrature amplitude modulation (QAM) input constellations.Comment: 9 pages with 12 figures. Preparing for submissio

Ontology Mapping of PATO to YATO for the improvement of interoperability of quality description

To facilitate broad interoperability for phenotype information between different ontological frameworks, we developed a reference ontology, PATO2YATO_Quality, with the careful mapping of terms of PATO which is a quality ontology commonly used for biological phenotype annotation to the latest top-level ontology, YATO, which represents advanced modeling of quality-related concepts. As a result, YATO framework enabled to describe changes of phenotypic qualities along the courses of time in ontologically correct way and sophisticated classification and representation of interrelationships among quality-related concepts to provide fully integration of qualitative values and quantitative values obtained from phenotyping experiments and advanced representation of more detailed quality description. Thus, PATO2YATO_Quality will contribute to advanced integration of phenotypic qualities

EVN Observations of HESS J1943+213: Evidence for an Extreme TeV BL Lac Object

We report on the 1.6 GHz (18 cm) VLBI observations of the unresolved, steady TeV source HESS J1943+213 located in the Galactic plane, performed with the European VLBI Network (EVN) in 2014. Our new observations with a nearly full EVN array provide the deepest image of HESS J1943+213 at the highest resolution ever achieved, enabling us to resolve the long-standing issues of the source identification. The milliarcsecond-scale structure of HESS J1943+213 has a clear asymmetric morphology, consisting of a compact core and a diffuse jet-like tail. This is broadly consistent with the previous e-EVN observations of the source performed in 2011, and re-analyzed in this work. The core component is characterized by the brightness temperature of $\gtrsim1.8 \times 10^9$ K, which is typical for low-luminosity blazars in general. Overall, radio properties of HESS J1943+213 are consistent with the source classification as an "extreme high-frequency-peaked BL Lac object". Remarkably, we note that since HESS J1943+213 does not reveal any optical or infrared signatures of the AGN activity, it would never be recognized and identified as a BL Lac object, if not its location close to the Galactic plane where the High Energy Stereoscopic System has surveyed, and the follow-up dedicated X-ray and radio studies triggered by the source detection in the TeV range. Our results suggest therefore a presence of an unrecognized, possibly very numerous population of particularly extreme HBLs, and simultaneously demonstrate that the low-frequency VLBI observations with high-angular resolution are indispensable for a proper identification of such objects.Comment: 8 pages, 3 figures, accepted to ApJ

Lachmanテスト時に発生する膝関節音 : 健常膝と前十字靭帯損傷膝での比較検討

BACKGROUND: The Lachman test is clinically considered to be a reliable physical examination for anterior cruciate ligament (ACL) deficiency. However, the test involves subjective judgement of differences in tibial translation and endpoint quality. An auscultation system has been developed to allow assessment of the Lachman test. The knee joint sound during the Lachman test was analyzed using fast Fourier transformation. The purpose of the present study was to quantitatively evaluate knee joint sounds in healthy and ACL-deficient human knees. METHODS: Sixty healthy volunteers and 24 patients with ACL injury were examined. The Lachman test with joint auscultation was evaluated using a microphone. Knee joint sound during the Lachman test (Lachman sound) was analyzed by fast Fourier transformation. As quantitative indices of the Lachman sound, the peak sound (Lachman peak sound) as the maximum relative amplitude (acoustic pressure) and its frequency were used. RESULTS: In healthy volunteers, the mean Lachman peak sound of intact knees was 100.6 Hz in frequency and -45 dB in acoustic pressure. Moreover, a sex difference was found in the frequency of the Lachman peak sound. In patients with ACL injury, the frequency of the Lachman peak sound of the ACL-deficient knees was widely dispersed. In the ACL-deficient knees, the mean Lachman peak sound was 306.8 Hz in frequency and -63.1 dB in acoustic pressure. If the reference range was set at the frequency of the healthy volunteer Lachman peak sound, the sensitivity, specificity, positive predictive value, and negative predictive value were 83.3%, 95.6%, 95.2%, and 85.2%, respectively. CONCLUSION: Knee joint auscultation during the Lachman test was capable of judging ACL deficiency on the basis of objective data. In particular, the frequency of the Lachman peak sound was able to assess ACL condition.博士（医学）・甲第673号・平成29年6月28日Copyright © 2016 The Japanese Orthopaedic Association. Published by Elsevier B.V. All rights reserved

Selective loss of Purkinje cells in a patient with anti-gliadin-antibody-positive autoimmune cerebellar ataxia

The patient was an 84-year-old woman who had the onset of truncal ataxia at age 77 and a history of Basedow's disease. Her ataxic gait gradually deteriorated. She could not walk without support at age 81 and she was admitted to our hospital at age 83. Gaze-evoked nystagmus and dysarthria were observed. Mild ataxia was observed in all limbs. Her deep tendon reflex and sense of position were normal. IgA anti-gliadin antibody, IgG anti-gliadin antibody, anti-SS-A/Ro antibody, anti-SS-B/La antibody and anti-TPO antibody were positive. A conventional brain MRI did not show obvious cerebellar atrophy. However, MRI voxel based morphometry (VBM) and SPECT-eZIS revealed cortical cerebellar atrophy and reduced cerebellar blood flow. IVIg treatment was performed and was moderately effective. After her death at age 85, the patient was autopsied. Neuropathological findings were as follows: selective loss of Purkinje cells; no apparent degenerative change in the efferent pathways, such as the dentate nuclei or vestibular nuclei; no prominent inflammatory reaction. From these findings, we diagnosed this case as autoimmune cerebellar atrophy associated with gluten ataxia. All 3 autopsies previously reported on gluten ataxia have noted infiltration of inflammatory cells in the cerebellum

Effects of Nutritional Support Combined with Neuromuscular Electrical Stimulation on Muscle Strength and Thickness: A Randomized Controlled Trial in Healthy Young Adult Males

In the management of post-injury patients with activity limitations, methods to prevent musculoskeletal disorders and hasten recovery are important. This randomized controlled, single-blinded study was a preliminary investigation of the combined effect of nutritional support with neuromuscular electrical stimulation (NMES) on muscle strength and thickness. Healthy young adult males (median age, 21 years) were enrolled; each of their hands was randomly assigned to one of the following four groups: Placebo, Nutrition, NMES, and Nutrition + NMES. All participants received whey protein or placebo (3x/week for 6 weeks) and NMES training (3x/week for 6 weeks) on the abductor digiti minimi (ADM) muscle of either the left or right hand. ADM muscle strength and thickness were analyzed at baseline and at week 7. We analyzed 38 hands (9 Placebo, 10 Nutrition, 9 NMES, 10 Nutrition + NMES). There was significantly greater muscle strengthening in the Nutrition + NMES group compared to the Placebo group or the NMES group, but no significant difference in gain of muscle thickness. The combined intervention may be effective in improving muscle strength. Future clinical trials targeting various muscles after sports-related injuries are warranted