13,839 research outputs found
The link between neuroinflammation and the neurovascular unit in synucleinopathies.
The neurovascular unit (NVU) is composed of vascular cells, glial cells, and neurons. As a fundamental functional module in the central nervous system, the NVU maintains homeostasis in the microenvironment and the integrity of the blood-brain barrier. Disruption of the NVU and interactions among its components are involved in the pathophysiology of synucleinopathies, which are characterized by the pathological accumulation of α-synuclein. Neuroinflammation contributes to the pathophysiology of synucleinopathies, including Parkinson's disease, multiple system atrophy, and dementia with Lewy bodies. This review aims to summarize the neuroinflammatory response of glial cells and vascular cells in the NVU. We also review neuroinflammation in the context of the cross-talk between glial cells and vascular cells, between glial cells and pericytes, and between microglia and astroglia. Last, we discuss how α-synuclein affects neuroinflammation and how neuroinflammation influences the aggregation and spread of α-synuclein and analyze different properties of α-synuclein in synucleinopathies
Weak Field Phase Diagram for an Integer Quantum Hall Liquid
We study the localization properties in the transition from a two-dimensional
electron gas at zero magnetic field into an integer quantum Hall (QH) liquid.
By carrying out a direct calculation of the localization length for a finite
size sample using a transfer matrix technique, we systematically investigate
the field and disorder dependences of the metal-insulator transition in the
weak field QH regime. We obtain a different phase diagram from the one
conjectured in previous theoretical studies. In particular, we find that: (1)
the extended state energy for each Landau level (LL) is {\it always}
linear in magnetic field; (2) for a given Landau level and disorder
configuration there exists a critical magnetic field below which the
extended state disappears; (3) the lower LLs are more robust to the
metal-insulator transition with smaller . We attribute the above results
to strong LL coupling effect. Experimental implications of our work are
discussed.Comment: 4 pages, ReVTeX 3.0, 4 figures (available upon request
Dielectric nonlinearity of relaxor ferroelectric ceramics at low ac drives
Dielectric nonlinear response of
(PbMgNbO)(PbTiO) (0.9PMN-0.1PT) relaxor
ceramics was investigated under different ac drive voltages. It was observed
that: (i) the dielectric permittivity is independent on ac field amplitude at
high temperatures; (ii) with increasing ac drive, the permittivity maximum
increases, and the temperature of the maximum shifts to lower temperature;
(iii) the nonlinear effect is weakened when the measurement frequency
increases. The influences of increasing ac drive were found to be similar to
that of decreasing frequency. It is believed that the dielectric nonlinearities
of relaxors at low drives can be explained by the phase transition theory of
ergodic space shrinking in succession. A Monte Carlo simulation was performed
on the flips of micro polarizations at low ac drives to verify the theory.Comment: Submitted to J. Phys.: Cond. Matte
Broadband Radio Spectral Observations of Solar Eclipse on 2008-08-01 and Implications on the Quiet Sun Atmospheric Model
Based on the joint-observations of the radio broadband spectral emissions of
solar eclipse on August 1, 2008 at Jiuquan (total eclipse) and Huairou (partial
eclipse) at the frequencies of 2.00 -- 5.60 GHz (Jiuquan), 2.60 -- 3.80 GHZ
(Chinese solar broadband radiospectrometer, SBRS/Huairou), and 5.20 -- 7.60 GHz
(SBRS/Huairou), the authors assemble a successive series of broadband spectrum
with a frequency of 2.60 -- 7.60 GHz to observe the solar eclipse
synchronously. This is the first attempt to analyze the solar eclipse radio
emission under the two telescopes located at different places with broadband
frequencies in the periods of total and partial eclipse. With these analyses,
the authors made a new semiempirical model of the coronal plasma density of the
quiet Sun and made a comparison with the classic models.Comment: 10 pages, 4 figures, published on Sci. China Ser. G, 2009, Vol.52,
page 1765-177
Higher order Jordan Osserman Pseudo-Riemannian manifolds
We study the higher order Jacobi operator in pseudo-Riemannian geometry. We
exhibit a family of manifolds so that this operator has constant Jordan normal
form on the Grassmannian of subspaces of signature (r,s) for certain values of
(r,s). These pseudo-Riemannian manifolds are new and non-trivial examples of
higher order Osserman manifolds
Analytical solution for the Fermi-sea energy of two-dimensional electrons in a magnetic field: lattice path-integral approach and quantum interference
We derive an exact solution for the total kinetic energy of noninteracting
spinless electrons at half-filling in two-dimensional bipartite lattices. We
employ a conceptually novel approach that maps this problem exactly into a
Feynman-Vdovichenko lattice walker. The problem is then reduced to the analytic
study of the sum of magnetic phase factors on closed paths. We compare our
results with the ones obtained through numerical calculations.Comment: 5 pages, RevTe
Stable, Efficient, and All-Solution-Processed Quantum Dot Light-Emitting Diodes with Double-Sided Metal Oxide Nanoparticle Charge Transport Layers
Cataloged from PDF version of article.An efficient and stable quantum dot light-emitting diode (QLED) with double-sided metal oxide (MO) nanoparticle (NP) charge transport layers is fabricated by utilizing the solution-processed tungsten oxide (WO3) and zinc oxide (ZnO) NPs as the hole and electron transport layers, respectively. Except for the electrodes, all other layers are deposited by a simple spin-coating method. The resulting MO NP-based QLEDs show excellent device performance, with a peak luminance of 21300 cd/m(2) at the emission wavelength of 516 nm, a maximal current efficiency of 4.4 cd/A, and a low turn-on voltage of 3 V. More importantly, with the efficient design of the device architecture, these devices exhibit a significant improvement in device stability and the operational lifetime of 95 h measured at room temperature can be almost 20-fold longer than that of the standard device
Symbolic Software for the Painleve Test of Nonlinear Ordinary and Partial Differential Equations
The automation of the traditional Painleve test in Mathematica is discussed.
The package PainleveTest.m allows for the testing of polynomial systems of
ordinary and partial differential equations which may be parameterized by
arbitrary functions (or constants). Except where limited by memory, there is no
restriction on the number of independent or dependent variables. The package is
quite robust in determining all the possible dominant behaviors of the Laurent
series solutions of the differential equation. The omission of valid dominant
behaviors is a common problem in many implementations of the Painleve test, and
these omissions often lead to erroneous results. Finally, our package is
compared with the other available implementations of the Painleve test.Comment: Published in the Journal of Nonlinear Mathematical Physics
(http://www.sm.luth.se/math/JNMP/), vol. 13(1), pp. 90-110 (Feb. 2006). The
software can be downloaded at either http://www.douglasbaldwin.com or
http://www.mines.edu/fs_home/wherema
Floating of Extended States and Localization Transition in a Weak Magnetic Field
We report results of a numerical study of non-interacting electrons moving in
a random potential in two dimensions in the presence of a weak perpendicular
magnetic field. We study the topological properties of the electronic
eigenstates within a tight binding model. We find that in the weak magnetic
field or strong randomness limit, extended states float up in energy. Further,
the localization length is found to diverge at the insulator phase boundary
with the same exponent as that of the isolated lowest Landau band (high
magnetic field limit).Comment: RevTex, 4 pages, 3 figures available upon reques
Multidimensional Conservation Laws: Overview, Problems, and Perspective
Some of recent important developments are overviewed, several longstanding
open problems are discussed, and a perspective is presented for the
mathematical theory of multidimensional conservation laws. Some basic features
and phenomena of multidimensional hyperbolic conservation laws are revealed,
and some samples of multidimensional systems/models and related important
problems are presented and analyzed with emphasis on the prototypes that have
been solved or may be expected to be solved rigorously at least for some cases.
In particular, multidimensional steady supersonic problems and transonic
problems, shock reflection-diffraction problems, and related effective
nonlinear approaches are analyzed. A theory of divergence-measure vector fields
and related analytical frameworks for the analysis of entropy solutions are
discussed.Comment: 43 pages, 3 figure
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