102 research outputs found
2-(4-Chlorophenoxy)-N′-[2-(4-chlorophenoxy)acetyl]acetohydrazide monohydrate
In the title compound, C16H14Cl2N2O4·H2O, the hydrazine and water molecules are both located on twofold axes. The C—N—N—C torsion angle is −72.66 (1)° and the dihedral angle between the two benzene rings is 67.33 (1)°. In the crystal, molecules are linked into a layer structure by a combination of O—H⋯O, N—H⋯O and C—H⋯O hydrogen bonds. Adjacent layers are linked into a three-dimensional network by Cl⋯Cl interactions [3.400 (2) Å]. C—H⋯π interactions are also observed
(Dimethoxyphosphoryl)(furan-2-yl)methyl 2-(2,4-dichlorophenoxy)acetate
In the title compound, C15H15Cl2O7P, the benzene and furan rings form a dihedral angle of 73.54 (1)°. In the crystal, weak intermolecular C—H⋯O hydrogen bonds link the molecules into layers parallel to (100)
Growth of Large Domain Epitaxial Graphene on the C-Face of SiC
Growth of epitaxial graphene on the C-face of SiC has been investigated.
Using a confinement controlled sublimation (CCS) method, we have achieved well
controlled growth and been able to observe propagation of uniform monolayer
graphene. Surface patterns uncover two important aspects of the growth, i.e.
carbon diffusion and stoichiometric requirement. Moreover, a new "stepdown"
growth mode has been discovered. Via this mode, monolayer graphene domains can
have an area of hundreds of square micrometers, while, most importantly, step
bunching is avoided and the initial uniformly stepped SiC surface is preserved.
The stepdown growth provides a possible route towards uniform epitaxial
graphene in wafer size without compromising the initial flat surface morphology
of SiC.Comment: 18 pages, 8 figure
Synthesis of Porous NiO and ZnO Submicro- and Nanofibers from Electrospun Polymer Fiber Templates
Porous nickel oxide (NiO) and zinc oxide (ZnO) submicro- and nanofibers were synthesized by impregnating electrospun polyacrylonitrile (PAN) fiber templates with corresponding metal nitrate aqueous solutions and subsequent calcination. The diameter of the NiO and ZnO fibers was closely related to that of the template fibers and larger diameters were obtained when using the template fibers with larger diameter. SEM results showed that the NiO and ZnO fibers have a large amount of pores with diameters ranging from 5 nm to 20 nm and 50 nm to 100 nm, respectively. Energy dispersive X-ray (EDX) spectra and X-ray diffraction (XRD) patterns testified that the obtained materials were NiO and ZnO with high purity
Human-like Energy Management Based on Deep Reinforcement Learning and Historical Driving Experiences
Development of hybrid electric vehicles depends on an advanced and efficient
energy management strategy (EMS). With online and real-time requirements in
mind, this article presents a human-like energy management framework for hybrid
electric vehicles according to deep reinforcement learning methods and
collected historical driving data. The hybrid powertrain studied has a
series-parallel topology, and its control-oriented modeling is founded first.
Then, the distinctive deep reinforcement learning (DRL) algorithm, named deep
deterministic policy gradient (DDPG), is introduced. To enhance the derived
power split controls in the DRL framework, the global optimal control
trajectories obtained from dynamic programming (DP) are regarded as expert
knowledge to train the DDPG model. This operation guarantees the optimality of
the proposed control architecture. Moreover, the collected historical driving
data based on experienced drivers are employed to replace the DP-based
controls, and thus construct the human-like EMSs. Finally, different categories
of experiments are executed to estimate the optimality and adaptability of the
proposed human-like EMS. Improvements in fuel economy and convergence rate
indicate the effectiveness of the constructed control structure.Comment: 8 pages, 10 figure
(S)-2-[(2,4-Dichlorophenyl)(hydroxy)methyl]-5,5-dimethyl-1,3,2-dioxaphosphinane 2-oxide
In the title molecule, C12H15Cl2O4P, the cyclic dioxaphosphinane ring adopts a chair conformation. In the crystal, intermolecular O—H⋯O hydrogen bonds link the molecules into chains propagating along the b axis
Type-I-IFN-Stimulated Gene TRIM5γ Inhibits HBV Replication by Promoting HBx Degradation
To understand the molecular mechanisms that
mediate the anti-hepatitis B virus (HBV) effect
of interferon (IFN) therapy, we conduct highthroughput
bimolecular fluorescence complementation
screening to identify potential physical
interactions between the HBx protein and 145 IFNstimulated
genes (ISGs). Seven HBx-interacting
ISGs have consistent and significant inhibitory effects
on HBV replication, among which TRIM5g suppresses
HBV replication by promoting K48-linked
ubiquitination and degradation of the HBx protein
on the K95 ubiquitin site. The B-Box domain of
TRIM5g under overexpression conditions is sufficient
to trigger HBx degradation and is responsible
both for interacting with HBx and recruiting
TRIM31, which is an ubiquitin ligase that triggers
HBx ubiquitination. High expression levels of
TRIM5g in IFN-a-treated HBV patients might indicate
a better therapeutic effect. Thus, our studies identify
a crucial role for TRIM5g and TRIM31 in promoting
HBx degradation, which may facilitate the development
of therapeutic agents for the treatment of patients
with IFN-resistant HBV infection
Uncovering lupus nephritis-specific genes and the potential of TNFRSF17-targeted immunotherapy: a high-throughput sequencing study
IntroductionLupus nephritis (LN) is a severe manifestation of systemic lupus erythematosus (SLE). This study aimed to identify LN specific-genes and potential therapeutic targets.MethodsWe performed high-throughput transcriptome sequencing on peripheral blood mononuclear cells (PBMCs) from LN patients. Healthy individuals and SLE patients without LN were used as controls. To validate the sequencing results, qRT-PCR was performed for 5 upregulated and 5 downregulated genes. Furthermore, the effect of the TNFRSF17-targeting drug IBI379 on patient plasma cells and B cells was evaluated by flow cytometry.ResultsOur analysis identified 1493 and 205 differential genes in the LN group compared to the control and SLE without LN groups respectively, with 70 genes common to both sets, marking them as LN-specific. These LN-specific genes were significantly enriched in the ‘regulation of biological quality’ GO term and the cell cycle pathway. Notably, several genes including TNFRSF17 were significantly overexpressed in the kidneys of both LN patients and NZB/W mice. TNFRSF17 levels correlated positively with urinary protein levels, and negatively with complement C3 and C4 levels in LN patients. The TNFRSF17-targeting drug IBI379 effectively induced apoptosis in patient plasma cells without significantly affecting B cells.DiscussionOur findings suggest that TNFRSF17 could serve as a potential therapeutic target for LN. Moreover, IBI379 is presented as a promising treatment option for LN
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