ORGB: Offset Correction in RGB Color Space for Illumination-Robust Image Processing

Single materials have colors which form straight lines in RGB space. However, in severe shadow cases, those lines do not intersect the origin, which is inconsistent with the description of most literature. This paper is concerned with the detection and correction of the offset between the intersection and origin. First, we analyze the reason for forming that offset via an optical imaging model. Second, we present a simple and effective way to detect and remove the offset. The resulting images, named ORGB, have almost the same appearance as the original RGB images while are more illumination-robust for color space conversion. Besides, image processing using ORGB instead of RGB is free from the interference of shadows. Finally, the proposed offset correction method is applied to road detection task, improving the performance both in quantitative and qualitative evaluations.Comment: Project website: https://baidut.github.io/ORGB

Implementing Positive Education via Virtual Reality

This research proposal intends to integrate the Positive Education model and Virtual Reality to improve students\u27 mental health. In this research, I am investigating whether Positive Education, when implemented via Virtual Reality, can reduce clinical rates of anxiety among students. To do this, I will write a VR educational application that implements the Positive Education model and conduct surveys to study its effects on students’ mental health. I expect to find that students who learn through the Positive Education model will have higher levels of confidence and lower levels of anxiety compared to students who learn in a standard classroom environment. I believe that this research will contribute to the conversations of integrating the Positive Education model and Virtual Reality in education

Boron Nitride Nanosheets for Metal Protection

Although the high impermeability of graphene makes it an excellent barrier to inhibit metal oxidation and corrosion, graphene can form a galvanic cell with the underlying metal that promotes corrosion of the metal in the long term. Boron nitride (BN) nanosheets which have a similar impermeability could be a better choice as protective barrier, because they are more thermally and chemically stable than graphene and, more importantly, do not cause galvanic corrosion due to their electrical insulation. In this study, the performance of commercially available BN nanosheets grown by chemical vapor deposition as a protective coating on metal has been investigated. The heating of the copper foil covered with the BN nanosheet at 250 {\deg}C in air over 100 h results in dramatically less oxidation than the bare copper foil heated for 2 h under the same conditions. The electrochemical analyses reveal that the BN nanosheet coating can increase open circuit potential and possibly reduce oxidation of the underlying copper foil in sodium chloride solution. These results indicate that BN nanosheets are a good candidate for oxidation and corrosion protection, although conductive atomic force microscopy analyses show that the effectiveness of the protection relies on the quality of BN nanosheets.Comment: With Supporting Informatio

STAT3 Genotypic Variant rs744166 and Increased Tyrosine Phosphorylation of STAT3 in IL-23 Responsive Innate Lymphoid Cells during Pathogenesis of Crohn\u27s Disease

Crohn\u27s disease (CD) results from dysregulated immune responses to gut microbiota in genetically susceptible individuals, affecting multiple areas of the gastrointestinal tract. Innate lymphoid cells (ILCs) are tissue-resident innate effector lymphocytes which play crucial roles in mucosal immune defense, tissue repair, and maintenance of homeostasis. The accumulation of IFN-γ-producing ILC1s and increased level of proinflammatory cytokines produced by ILCs has been observed in the inflamed terminal ileum of CD patients. To date, the precise mechanisms of ILC plasticity and gene regulatory pathways in ILCs remain unclear. Signal transducer and activator of transcription 3 (STAT3) regulates gene expression in a cell-specific, cytokine-dependent manner, involving multiple immune responses. This study proposes the positive correlation between the prevalence of STAT3 rs744166 risky allele A with the severity of disease in a cohort of 94 CD patients. In addition, the results suggest an increased STAT3 activity in the inflamed ileum of CD patients, compared to unaffected ileum sections. Notably, IL-23 triggers the differentiation of CD117+NKp44- ILC3s and induces the activation of STAT3 in both CD117+NKp44- and CD117-NKp44- ILC subsets, implying the involvement of STAT3 in the initiation of ILC plasticity. Moreover, carriage of STAT3 A risk allele exhibited a higher basal level of STAT3 tyrosine phosphorylation, and an increased IL-23 triggered the pSTAT3 level. We also demonstrated that there was no delayed dephosphorylation of STAT3 in ILCs of both A/A and G/G donors. Overall, the results of this study suggest that IL-23-induced activation of STAT3 in the CD117-NKp44- ILC1s involves in ILC1-to-ILC3 plasticity and a potential regulatory role of ILC1 function. Those genetically susceptible individuals carried STAT3 rs744166 risky allele appear to have higher basal and cytokine-stimulated activation of STAT3 signal, leading to prolonged inflammation and chronic relapse

Perception on the Quality of Life, Communication and Life Satisfaction among Individuals with Parkison’s and Their Caregivers

BACKGROUND: Speech impairment, which reduces Quality of Life (QOL), frequently occurs in individuals with Parkinson’s disease (PD). As speaking is required for social interaction, speech impairment can reduce one’s life satisfaction. Although QOL has been well-studied in individuals with PD, the QOL of their caregivers has seldom been investigated. This study compared the QOL of individuals with PD and their caregivers. The relationships between QOL, self-rated speech scale, and life satisfaction level were examined.METHOD: A total of 20 individuals with PD and their caregivers completed the Parkinson’s disease Questionnaire-39 (PDQ-39) scale and the Life Satisfaction Scale (LSS). In addition, PD participants were asked to complete the Self-Rated Speech Scale (SRSS) to rate their speech intelligibility.RESULT: PD participants reported significantly lower QOL scores than their caregivers. However, there was no difference between the two groups on the social support and stigma dimensions, indicating that both groups reported similar levels of social support and stigma in their daily lives. A moderate significant correlation was observed between the LSS and PDQ-39 scores in the PD group, suggesting that life satisfaction could affect their QOL. Moreover, moderate correlation was found between the LSS and SRSS, showing that participants self-reported speech intelligibility has an impact on their life satisfaction.CONCLUSION: In general, individuals with PD showed lower QOL than their caregivers. Given that the SRSS, LSS and QOL are moderately correlated, identifying patients’ perception on their speech intelligibility and life satisfaction could help clinicians to better understand their patients’ needs when delivering speech therapy services.

HEALTH SEEKING BEHAVIOR TOWARDS MINOR AILMENTS AMONG UNIVERSITY STUDENTS IN MALAYSIA

Objective: This study was conducted to identify the types of minor ailments encountered by university students in Malaysia and the action taken in response to these ailments. Methods: A cross-sectional study was conducted on undergraduate students from the various faculties in a major private and a public university in Malaysia. A researcher stationed at different areas of the universities to recruit respondents. If the student agreed to participate, he/she would sign a consent form and then self-filled a structured questionnaire. Results: Of the 856 respondents included in this study, 68.6% were female and 60.6% rated their health status as ‘good’ or ‘very good’. During the one month period prior to the study, 87.4% of the respondents encountered at least one minor ailment. The five most common minor ailments encountered were headache (58.1%), common cold (42.8%), sore throat (42.6%), cough (40.3%) and back pain (27.6%). The main actions taken were rest at home and self-medication. The most common drug used for the treatment of minor ailments was paracetamol (49% of the respondents). Other drugs were used by less than 10% of the respondents. The main source of information was from parents (63.7%), followed by doctors (59.9%), internet (57.9%), pharmacists (33.9%) and friends (33.5%). Conclusion: Headache is more common among university students compared to the general population. Further studies are required to understand the cause of headache among this population