Dependency of NELF-E-SLUG-KAT2B epigenetic axis in breast cancer carcinogenesis.

Cancer cells undergo transcriptional reprogramming to drive tumor progression and metastasis. Using cancer cell lines and patient-derived tumor organoids, we demonstrate that loss of the negative elongation factor (NELF) complex inhibits breast cancer development through downregulating epithelial-mesenchymal transition (EMT) and stemness-associated genes. Quantitative multiplexed Rapid Immunoprecipitation Mass spectrometry of Endogenous proteins (qPLEX-RIME) further reveals a significant rewiring of NELF-E-associated chromatin partners as a function of EMT and a co-option of NELF-E with the key EMT transcription factor SLUG. Accordingly, loss of NELF-E leads to impaired SLUG binding on chromatin. Through integrative transcriptomic and genomic analyses, we identify the histone acetyltransferase, KAT2B, as a key functional target of NELF-E-SLUG. Genetic and pharmacological inactivation of KAT2B ameliorate the expression of EMT markers, phenocopying NELF ablation. Elevated expression of NELF-E and KAT2B is associated with poorer prognosis in breast cancer patients, highlighting the clinical relevance of our findings. Taken together, we uncover a crucial role of the NELF-E-SLUG-KAT2B epigenetic axis in breast cancer carcinogenesis

Globalization and National Industrial Relations Systems: Theoretical Implications from the Singapore Case

In the 1960’s, Kerr and his associates (1973[1960]) — Dunlop, Harbison, and Myers— proposed the convergence thesis, which resonates with the “end of ideology” thesis propounded by Bell (1962). Not surprisingly, the thesis about the inevitability of societal convergence prompted some scholars to look for continuing diversity, an oft-cited prime example being Japan (Dore, 1973). Indeed, until the late 1980’s, Japan was still touted as a critical case which not only defied the convergence thesis, but could also serve as a growth model worthy of emulation by developing countries aspiring to First World living standards and, paradoxically, even developed countries experiencing economic stagnation (Vogel, 1980)

Perceptions of Governance Survey

doi:10.25540/9XZ0-T3M

Workplace power in Singapore: a paradox? Evidence from a 1998 national survey

Singapore workers are reputed to be highly disciplined, diligent, skillful, productive, and cooperative. In a tight labour market, though, they are likely to manifest organisational disloyalty and are given to job-hopping. Almost a quarter of all workers in Singapore are members of unions affiliated to the National Trades Union Congress (NTUC), the sole confederation of labour unions in Singapore. The NTUC operates in close partnership with the state and adopts a productionist orientation. This paper is based on data from the Social Indicators Research Project (SIRP) survey completed in 1998 in the midst of the Asian economic crisis. It focuses on four crucial indicators-job dimensions, union orientations, job satisfaction, and turnover propensity-to get a sense of how Singapore workers fare in terms of morale, quality of work life, and workplace power. This approach sees labour not as a mere factor of production, passively subject to market forces and managerial decisions which are oriented towards profits, but as a social actor with the potential and capacity to influence the conditions that affect work life. The paper observes that while executive-level employees enjoy greater job autonomy than rank-and-file workers, their greater dependence on senior management for extrinsic rewards and career prospects and their lack of access to union membership have rendered them somewhat less powerful than rank-and-file workers vis-à-vis their employing organisations. The paper also argues that while Singapore unions are productionist in orientation and non-adversarial towards capital and management, they can serve as a deterrent against oppressive company policies or victimisation by managers. This is a benefit accessible to rank-and-file workers, but less so to their executive-level counterparts

Class and Social Orientations: Key Findings from the Social Stratification Survey 2011

10.25818/ycg7-dpns1-84IPS Exchange Series (Institute of Policy Studies

Survey Of State-Society Relations Social Indicators Research Project Executive Summary Report

10.25818/4kfm-v5my1-63IPS Working Papers (Institute of Policy Studies

Survey Of State-Society Relations Social Indicators Research Project Executive Summary Report

The executive summary reports on major findings from a survey conducted among a random sample of 1,054 Singaporeans and Permanent Residents aged 18 to 65. Focus is on views of public policies in three areas, namely, political participation, social capital and trust and provision of public goods and services. [Working Paper No.5]survey,Singaporeans, Permanent Residents, social capital, public goods, services