Values, nation building and control: The Singapore mass media in the next lap

1990 marked a significant change in the political history of Singapore – it was the year Mr. Lee Kuan Yew handed over his role as Singapore’s leader to Mr. Goh Chok Tong. Termed “The Next Lap”, this new period of Singapore’s history was heralded in as a period of change and new directions for Singapore and Singaporeans. This thesis explores the introduction of the Next Lap, the promises of positive changes and the potential effect this new era may have on the Singapore Government’s intimate relationship with and control of the media as a Nation Building apparatus. It looks at the Government’s continued desire to control the media and struggle to re-negotiate its position due to the development of new media technologies, such as satellite television, which have the ability to elude direct control over its broadcasting capacity.The mass media in Singapore have always been strictly controlled through the practice of censorship, strict broadcasting guidelines (and severe penalties for those who do not abide by these guidelines) as well as self-censorship. Through strict control of the mass media, the Government has been able to use it to promote desirable values which have been identified as crucial to the process of Nation Building. These values include putting the nation before community and the community before self, the importance of the family as the basic unit of society and racial and religious harmony. However, recently there have been signs that the Singapore Government has realised the need to make some changes to their broadcasting policies. The change coincided with the transfer of leadership from the former Prime Minister, Lee Kuan Yew, to the current Prime Minister, Goh Chok Tong. When he came into office, Prime Minister Goh promised that there would be more openness. This thesis examines how the policy of \u27openness\u27 applies to the mass media and the possible consequences of the changes implicit in the new policy on the mass media. Results of the change in political climate are reflected in the recent introduction of three pay television channels in Singapore and a review of the censorship laws. To many Singaporeans, this is a welcome: sign, an opportunity for more choice. To the Government, it involves an important question: To what degree should they relax control over the media and bow to the demands of the public for more freedom and choice. The relationship between the Next Lap and the mass media will be examined through the application of Hobsbawm\u27s (1983) theory of invented traditions\u27, Bhabha\u27s (1990a) discussions on the difficulties of locating a nation1 s cultural identity and Foucault\u27s (1979) analysis on the art of government. By applying these theories, I will show that the Next Lap.is an ongoing process of Singapore political and social construction. With the apparent change in the political climate in Singapore, it is timely to explore the relationship between the Government and the mass media after 25 years of independence. By looking at the important social. and political variables, I will show that the relaxation of mass media in the Next Lap represents a continuation of the Singaporean government\u27s \u27desire to control the media for Nation Building activities

Corporate governance : the case for Asian REITs

Thesis (S.M.)--Massachusetts Institute of Technology, Program in Real Estate Development in Conjunction with the Center for Real Estate , 2009.This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.Cataloged from student submitted PDF version of thesis.Includes bibliographical references (p. 71-73).At the entity level, the design of sound corporate governance mechanisms is critical for REITs that are preparing to go public. At the industry level, issues of transparency and corporate governance are consequential to the further development of REITs in Asia. This study looks at various REIT regimes and corporate governance systems around the world. It then proceeds to examine the governance structures in place at the time of an IPO in the emerging REIT market of Singapore. The mechanisms of corporate governance used to evaluate the IPO of the REIT include (i) board structure and composition, (ii) ownership, (iii) compensation, and (iv) takeover defenses. The findings point to evidence that corporate governance structures are not "one size fits all" and must be tailored to fit the appropriate institutional context.by Denise Tan.S.M

Ultrasensitive Detection of MCF-7 Cells with a Carbon Nanotube-Based Optoelectronic-Pulse Sensor Framework

Biosensors are of vital significance for healthcare by supporting the management of infectious diseases for preventing pandemics and the diagnosis of life-threatening conditions such as cancer. However, the advancement of the field can be limited by low sensing accuracy. Here, we altered the bioelectrical signatures of the cells using carbon nanotubes (CNTs) via structural loosening effects. Using an alternating current (AC) pulse under light irradiation, we developed a photo-assisted AC pulse sensor based on CNTs to differentiate between healthy breast epithelial cells (MCF-10A) and luminal breast cancer cells (MCF-7) within a heterogeneous cell population. We observed a previously undemonstrated increase in current contrast for MCF-7 cells with CNTs compared to MCF-10A cells with CNTs under light exposure. Moreover, we obtained a detection limit of ∼1.5 × 10^{3} cells below a baseline of ∼1 × 10^{4} cells for existing electrical-based sensors for an adherent, heterogeneous cell population. All-atom molecular dynamics (MD) simulations reveal that interactions between the embedded CNT and cancer cell membranes result in a less rigid lipid bilayer structure, which can facilitate CNT translocation for enhancing current. This as-yet unconsidered cancer cell-specific method based on the unique optoelectrical properties of CNTs represents a strategy for unlocking the detection of a small population of cancer cells and provides a promising route for the early diagnosis, monitoring, and staging of cancer

Unexpected X Chromosome Skewing during Culture and Reprogramming of Human Somatic Cells Can Be Alleviated by Exogenous Telomerase

SummarySomatic tissues in female eutherian mammals are mosaic due to random X inactivation. In contrast to mice, X chromosome reactivation does not occur during the reprogramming of human female somatic cells to induced pluripotent stem cells (iPSCs), although this view is contested. Using balanced populations of female Rett patient and control fibroblasts, we confirm that all cells in iPSC colonies contain an inactive X, and additionally find that all colonies made from the same donor fibroblasts contain the same inactive X chromosome. Notably, this extreme “skewing” toward a particular dominant, active X is also a general feature of primary female fibroblasts during proliferation, and the skewing seen in reprogramming and fibroblast culture can be alleviated by overexpression of telomerase. These results have important implications for in vitro modeling of X-linked diseases and the interpretation of long-term culture studies in cancer and senescence using primary female fibroblast cell lines

The Inception of Star Cluster Formation Revealed by [CII] Emission Around an Infrared Dark Cloud

We present SOFIA-upGREAT observations of [CII] emission of Infrared Dark Cloud (IRDC) G035.39-00.33, designed to trace its atomic gas envelope and thus test models of the origins of such clouds. Several velocity components of [CII] emission are detected, tracing structures that are at a wide range of distances in the Galactic plane. We find a main component that is likely associated with the IRDC and its immediate surroundings. This strongest emission component has a velocity similar to that of the $^{13}$CO(2-1) emission of the IRDC, but offset by $\sim3\:{\rm km\:s}^{-1}$ and with a larger velocity width of $\sim9\:{\rm km\:s}^{-1}$. The spatial distribution of the [CII] emission of this component is also offset predominantly to one side of the dense filamentary structure of the IRDC. The CII column density is estimated to be of the order of $\sim10^{17}-10^{18}\,{\rm cm}^{-2}$. We compare these results to the [CII] emission from numerical simulations of magnetized, dense gas filaments formed from giant molecular cloud (GMC) collisions, finding similar spatial and kinematic offsets. These observations and modeling of [CII] add further to the evidence that IRDC G035.39-00.33 has been formed by a process of GMC-GMC collision, which may thus be an important mechanism for initiating star cluster formation.Comment: 5 pages, 4 figures, submitted to MNRAS Letter

Vitamin D deficiency and prognostics among patients with pancreatic adenocarcinoma

BACKGROUND: The prevalence of vitamin D deficiency among patients with cancer has been previously reported. Because vitamin D is fat soluble, patients with pancreatic adenocarcinoma may have an especially high risk of vitamin D deficiency in association with ongoing and varying degrees of malabsorption. However, little is known about the correlation between vitamin D status and prognosis in these patients. METHODS: We conducted a retrospective review of vitamin D status in patients with pancreatic adenocarcinoma who were treated at Siteman Cancer Center. Patients’ demographic information, clinical staging at the time of vitamin D assessment, vitamin D levels, and survival data were collected. Vitamin D deficiency was defined as a serum 25-hydroxyvitamin D (25[OH]D) level of less than 20 ng/mL, and vitamin D insufficiency was defined as a 25(OH)D level of between 20 ng/mL and 30 ng/mL. RESULTS: Between December 2007 and June 2011, 178 patients with pancreatic adenocarcinoma had their vitamin D levels checked at the time of initial visit at this center. Of these 178 patients, 87 (49%) had vitamin D deficiency, and 44 (25%) had vitamin D insufficiency. The median 25(OH)D level was significantly lower among nonwhite patients and among patients with stage I and II disease. A 25(OH)D level of less than 20 ng/mL was found to be associated with poor prognosis (p = 0.0019) in patients with stage III and IV disease. CONCLUSIONS: Vitamin D insufficiency and deficiency were prevalent among patients with pancreatic adenocarcinoma. The vitamin D level appears to be prognostic for patients with advanced pancreatic adenocarcinoma, and its effects should be further examined in a prospective study

Angioimmunoblastic T-cell Lymphoma: A Mimic for Lupus

New-onset systemic lupus erythematosus (SLE) is uncommon in elderly patients. We report the case of a 71-year-old woman who was diagnosed with SLE based on clinical manifestations of fever, alopecia, bicytopenia, hepatomegaly, lymphadenopathy, glomerulonephritis, positive antinuclear antibody (ANA) and anti-double stranded DNA (anti-dsDNA) antibody. Renal biopsy was consistent with lupus nephritis and excision biopsy of a right inguinal lymph node was initially reported as having features of reactive hyperplasia. However, a more careful review of the lymph node biopsy subsequently confirmed a concurrent angioimmunoblastic T-cell lymphoma. This case illustrates the importance of investigating secondary causes and possible alternative diagnoses in patients who present with atypical features of connective tissue disease, and the challenges in diagnosing a rare form of lymphoma