A five-step synthesis of psilocin from indole-3-carbaldehyde

金沢大学大学院自然科学研究科生理活性物質科学金沢大学薬学部A novel preparative method of psilocin was established in only five steps from indole-3-carbaldehyde in 50% overall yield

Synthetic Studies of Psilocin Analogs Having Either a Formyl Group or Bromine Atom at the 5- or 7-Position

Psilocin analogs having either a formyl group (9—12) or a bromine atom (13—18) at the 5- or 7-position have been prepared for the first time. Syntheses of 5- and 7-bromo derivatives of 4-hydroxy- (23, 24, 28) and 4-benzyloxyindole-3-carbaldehyde (19, 25, 29, 30), 4-benzyloxyindole-3-acetonitriles (20, 31), and 4-benzyloxy-N, N-dimethyltryptamine (32, 34, 35) have also been established