Diffusion of a nano-wire through an obstacle field

We report the first experimental realization of a rod diffusing in a two dimensional obstacle field following the single rod dynamics. We use a silver nanowire as our rod and two types of obstacles: repelling light beams and polymer pillars. We study the effect of hydrodynamic interactions on the transport of the rod, comparing both experimental realizations and recent simulations. We propose a new framework for analyzing the transport through such systems and predict a new superdiffusive regime of rod transport at high obstacle concentration and short times.Comment: 5 pages, 5 figures, in press in PRE rapid communications, 201

Diffusive contact between randomly driven colloidal suspensions

We study the relaxation process of two driven colloidal suspensions in diffusive contact to a steady state, similar to thermalization. We start by studying a single suspension, subjecting it to random driving forces via holographic optical tweezers, which agitate it to a higher effective temperature. Interestingly, the effective temperature of the suspension, defined by the Einstein relation, exhibits a non-monotonic dependence on the driving frequency. Next, we follow the flux of particles between two such suspensions in diffusive contact, starting from a uniform density and relaxing to a state with zero net particle flux. The density remains uniform for systems with different frequencies but equal effective temperatures. At high driving frequencies, we show that the density distribution at steady state is determined by equating the ratio of the chemical potential to the effective temperature in both systems, mirroring thermal equilibrium behavior.Comment: 5 pages 5 figures + S

NAF-1 and mitoNEET are central to human breast cancer proliferation by maintaining mitochondrial homeostasis and promoting tumor growth

Mitochondria are emerging as important players in the transformation process of cells, maintaining the biosynthetic and energetic capacities of cancer cells and serving as one of the primary sites of apoptosis and autophagy regulation. Although several avenues of cancer therapy have focused on mitochondria, progress in developing mitochondria-targeting anticancer drugs nonetheless has been slow, owing to the limited number of known mitochondrial target proteins that link metabolism with autophagy or cell death. Recent studies have demonstrated that two members of the newly discovered family of NEET proteins, NAF-1 (CISD2) and mitoNEET (mNT; CISD1), could play such a role in cancer cells. NAF-1 was shown to be a key player in regulating autophagy, and mNT was proposed to mediate iron and reactive oxygen homeostasis in mitochondria. Here we show that the protein levels of NAF-1 and mNT are elevated in human epithelial breast cancer cells, and that suppressing the level of these proteins using shRNA results in significantly reduced cell proliferation and tumor growth, decreased mitochondrial performance, uncontrolled accumulation of iron and reactive oxygen in mitochondria, and activation of autophagy. Our findings highlight NEET proteins as promising mitochondrial targets for cancer therapy

Relationships between xylem embolism and tree functioning during drought, recovery, and recurring drought in Aleppo pine

Recent findings suggest that trees can survive high levels of drought-induced xylem embolism. In many cases, the embolism is irreversible and, therefore, can potentially affect post-drought recovery and tree function under recurring droughts. We examined the development of embolism in potted Aleppo pines, a common species in hot, dry Mediterranean habitats. We asked (1) how post-drought recovery is affected by different levels of embolism and (2) what consequences this drought-induced damage has under a recurring drought scenario. Young trees were dehydrated to target water potential (Ψx) values of −3.5, −5.2 and −9.5 MPa (which corresponded to ~6%, ~41% and ~76% embolism), and recovery of the surviving trees was measured over an 8-months period (i.e., embolism, leaf gas-exchange, Ψx). An additional group of trees was exposed to Ψx of −6.0 MPa, either with or without preceding drought (Ψx of −5.2 MPa) to test the effect of hydraulic damage during repeated drought. Trees that reached −9.5 MPa died, but none from the other groups. Embolism levels in dying trees were on average 76% of conductive xylem and no tree was dying below 62% embolism. Stomatal recovery was negatively proportional to the level of hydraulic damage sustained during drought, for at least a month after drought relief. Trees that experienced drought for the second time took longer to reach fatal Ψx levels than first-time dehydrating trees. Decreased stomatal conductance following drought can be seen as “drought legacy,” impeding recovery of tree functioning, but also as a safety mechanism during a consecutive drought

‘Dominant ethnicity’ and the ‘ethnic-civic’ dichotomy in the work of A. D. Smith

This article considers the way in which the work of Anthony Smith has helped to structure debates surrounding the role of ethnicity in present-day nations. Two major lines of enquiry are evident here. First, the contemporary role of dominant ethnic groups within 'their' nations and second, the interplay between ethnic and civic elements in nationalist argument. The two processes are related, but maintain elements of distinctiveness. Smith's major contribution to the dominant ethnicity debate has been to disembed ethnicity from the ideologically-charged and/or anglo-centric discourse of ethnic relations and to place it in historical context, thereby opening up space for dominant group ethnicity to be considered as a distinct phenomenon. This said, Smith's work does not adequately account for the vicissitudes of dominant ethnicity in the contemporary West. Building on the classical works of Hans Kohn and Friedrich Meinecke, Anthony Smith has also made a seminal contribution to the debate on civic and ethnic forms of national identity and nationalist ideology. As well as freeing this debate from the strong normative overtones which it has often carried, he has continued to insist that the terms civic and ethnic should be treated as an ideal-typical distinction rather than a scheme of classification

Physics-Guided Inverse Regression for Crop Quality Assessment

We present an innovative approach leveraging Physics-Guided Neural Networks (PGNNs) for enhancing agricultural quality assessments. Central to our methodology is the application of physics-guided inverse regression, a technique that significantly improves the model's ability to precisely predict quality metrics of crops. This approach directly addresses the challenges of scalability, speed, and practicality that traditional assessment methods face. By integrating physical principles, notably Fick`s second law of diffusion, into neural network architectures, our developed PGNN model achieves a notable advancement in enhancing both the interpretability and accuracy of assessments. Empirical validation conducted on cucumbers and mushrooms demonstrates the superior capability of our model in outperforming conventional computer vision techniques in postharvest quality evaluation. This underscores our contribution as a scalable and efficient solution to the pressing demands of global food supply challenges

Review symposium: What went wrong with liberal multiculturalism?

International audienc