Measurement of Macular Blood Flow in Eyes with Primary Open Angle Glaucoma

Purpose: To measure the macular blood flow in eyes with different stages of primary open angle glaucoma (POAG) and to compare the macular blood flow values obtained from glaucomatous eyes with those measured in the normal eyes

High Intraocular Pressure After Carbamazepine and Gabapentin Intake in a Pseudoexfoliative Patient

Introduction: Psychotropic agents may frequently be associated with ocular adverse effects, which include angle-closure glaucoma. We report a case of pseudoexfoliation glaucoma in which intraocular pressure (IOP) increased within hours after carbamazepine and gabapentin intake, with no observable evidence of any angle closure

The Impact of Pupillary Dilation on Intraocular Pressure and Anterior Segment Morphology in Subjects with and without Pseudoexfoliation

Purpose: To investigate the change in pre- and post-dilation anterior segment parameters and intraocular pressure (IOP) of patients with and without pseudoexfoliation, after topical application of phenylephrine HCl 10% and tropicamide 1%

Quadrantwise Comparison of Lens-Iris Distance in Patients With Pseudoexfoliation Syndrome and Age-matched Controls

WOS: 000374819400025PubMed ID: 25068467Purpose: To perform a quadrantwise comparison of the minimum distance between the posterior iris and the anterior lens in eyes with pseudoexfoliation syndrome (PXS) and age-matched controls. Patients and Methods: This study was designed as a prospective cross-sectional study. The study population consisted of 60 patients with PXS and 50 age-matched controls. Anterior segment Scheimpflug images of segments 90 to 270, 135 to 315, 180 to 360, and 225 to 45 degrees were exported as high-quality JPEG images (1920 pixels wide, 1048 pixels high; each pixel having a physical dimension of 8.064 x 8.064 mu m) for further evaluation. The images were analyzed by Image J software. Minimum lens-iris distance (MLID) of the superior, inferior, nasal, and temporal quadrants were analyzed and compared between the groups. Anterior chamber depth, anterior chamber angle, pupillary diameter, average of K1 and K2 (Km), and cataract grading system by Scheimpflug imaging [Oculus Pentacam Nucleus Grading System (PNS)] were also assessed. Results: The MLIDs of all quadrants in eyes with PXS were shorter than controls and these differences were statistically significant (P < 0.05). The shortest distance was recorded in the inferior quadrant followed by the superior, temporal, and nasal quadrants in both groups. Pupillary diameter was the only variable found to be correlated with mean global MLID at a statistically significant level (r = -0.465, P < 0.001; adjusted for age, sex, anterior chamber angle, anterior chamber depth, PNS, and Km). Conclusion: Eyes with PXS manifested with shorter mean MLID than controls

Posture-induced changes in intraocular pressure: comparison of pseudoexfoliation glaucoma and primary open-angle glaucoma

The objective of this study was to evaluate and compare the IOP values in the sitting and supine positions in primary open-angle glaucoma (POAG) and pseudoexfoliation glaucoma (PXG) patients. We also investigated possible relationships between the level of visual field damage and postural IOP change

Corneal Decompensation after Selective Laser Trabeculoplasty

A 64-year-old Caucasian man referred for decreased vision after selective laser trabeculoplasty (SLT). Slit lamp examination revealed diffuse corneal edema. Despite intensive topical treatment including steroids, corneal edema did not resolve; on the contrary, it advanced to bullous keratopathy. Corneal edema after SLT is an exceptionally rare complication and in all of the previous reports edema resolved with medical treatment. To the best of our knowledge, this is the first report presenting persistent corneal edema after SLT

Demographic features of subjects with congenital glaucoma

Context: Congenital glaucoma is a potentially blinding ocular disease of the childhood. Identification of the possible associated risk factors and may be helpful for prevention or early detection of this public health problem. Aims: To demonstrate the demographic features of congenital glaucoma subjects. Setting and Design: The charts of congenital glaucoma patients referred to Tamcelik Glaucoma Center were retrospectively reviewed through the dates of 2000 and 2013. Materials and Methods: Analyzed data included diagnosis, age at first presentation, symptoms at first presentation, laterality of the disease, sex, presence of consanguinity, family history of congenital glaucoma, maturity of the fetus at delivery, and maternal age at conception. Statistical Analysis Used: Statistical Package for Social Sciences (SPSS) version 19.0 by IBM (SPSS Inc, Chicago, Illinois, USA) was used to compare the mean of continuous variables with Student's t-test and analysis of variance (ANOVA) and chi(2) test was used to test differences in proportions of categorical variables. Results: The data of 600 eyes of 311 patients were analyzed. The distribution of primary and secondary congenital glaucoma among the patients were 63.3% (n = 197) and 36.7% (n = 114), respectively. Of the 311 patients, 57.2% (n = 178) were male and 42.8% (n = 133) were female. The overall frequency of bilateral disease was 92.3% (n = 287). Overall rate of consanguinity and positive family history was 45.3% (n = 141) and 21.2% (n = 66), respectively. Conclusions: Bilateral disease in this study was more common than previously reported studies. Positive family history was more frequent in primary congenital glaucoma although not statistically significant

The change in intraocular pressure after pupillary dilation in eyes with pseudoexfoliation glaucoma, primary open angle glaucoma, and eyes of normal subjects

To evaluate the change in intraocular pressure (IOP) after pharmacologic dilation in eyes with primary open angle glaucoma (POAG), pseudoexfoliation glaucoma (PXG), and eyes of normal subjects. This cross-sectional study was conducted in a university hospital-based setting. Patients with PXG, POAG, and normal subjects were consecutively selected and included in the study. Of the 125 eyes of 125 subjects; 46 (25 female) had PXG, 42 (29 female) had POAG, and 37 (20 female) belonged to the control group. Pharmacologic dilation procedure consisted of instillation of topical phenylephrine HCL 10 % followed 5 min by tropicamide 1 %. Studied variables were pre- and post-dilation IOP and also baseline measurements of anterior chamber angle, central corneal thickness, and pupillary diameter by Pentacam HR (Oculus, Wetzlar, Germany). Clinically significant IOP change was defined as a change of a parts per thousand yen2 mmHg from baseline. Randomly selected single eye of each patient was included in the analysis. The mean pre:post-dilation IOP of eyes with PXG and POAG was 17.39 +/- A 3.89:17.54 +/- A 3.98 and 15.92 +/- A 2.37:16.07 +/- A 2.89 mmHg, respectively. The difference between the pre- and post-dilation IOP of eyes with PXG and POAG was not statistically significant. The eyes of control subjects, however, had a statistically significant reduction of IOP from 14.24 +/- A 2.88 to 13.54 +/- A 2.94 mmHg (P = 0.005). 28.3 % (13/46) of eyes with PXG, 16.7 % (7/42) of eyes with POAG, and 2.7 % (1/37) of control eyes showed a clinically significant IOP elevation from baseline after the dilation. In this study, glaucoma patients proportionally experienced a higher rate of clinically significant IOP elevation after pupillary dilation, when compared to normal subjects

Scleral tunnel for the implantation of glaucoma seton devices

The technique described in this paper shows how to use a long scleral tunnel for the implantation of anterior tube parts of glaucoma drainage devices. It involves the creation of a scleral tunnel beginning 10 mm behind the limbus and extending to the anterior chamber. Anterior tube parts of Krupin eye valve with disk is inserted through the scleral tunnel to the anterior chamber. The disk part is secured to the episclera as used in the standard technique. We have used this technique in 6 eyes of 6 consecutive patients with refractory glaucoma. The placement of anterior tubes as part of glaucoma seton devices was done in all patients. While mean intraocular pressure (IOP) was 39.3 +/- 4.9 mm Hg (ranged from 29 to 56 mm, Hg) preoperatively, it was 16.6 +/- 5.3 mm Hg (ranging from 11 to 25 ram Hg) at the end of follow up. Mean follow-up time was 7.16 +/- 1.16 months (ranging from 6 to 9 months). After surgery conjunctival erosion or displacement of the anterior tube and dellen formation were not found in any eyes. The use of a long scleral tunnel for the implantation of anterior tube parts of glaucoma seton devices offers some advantages over standard implantation techniques