The control of switching dc-dc converters : a general LQR problem

Author name used in this publication: C. K. LiVersion of RecordPublishe

An improved LQR-based controller for switching dc-dc converters

Author name used in this publication: C. K. LiVersion of RecordPublishe

PCR amplification of alleles at locus D17S5: population genetic study in Hong Kong Chinese and detection of allelic loss in patients with hepatocellular carcinoma

Abstract no. 2184published_or_final_versio

Diagnosis of dihydropyrimidinase deficiency in a Chinese boy with dihydropyrimidinuria

published_or_final_versio

HIGH-ENERGY EMISSIONS FROM THE GAMMA-RAY BINARY LS 5039

published_or_final_versio

Psychosocial and quality of life outcomes of prosthetic auricular rehabilitation with CAD/CAM technology.

published_or_final_versio

Suppression of hypoxia inducible factor-1α (HIF-1α) by YC-1 is dependent on murine double minute 2 (Mdm2)

Inhibition of HIF-1α activity provides an important strategy for the treatment of cancer. Recently, 3-(5′-hydroxymethyl-2′-furyl)-1-benzyl indazole (YC-1) has been identified as an anti-HIF-1α drug in cancer therapy with unclear molecular mechanism. In the present study, we aimed to investigate the effect and mechanism of YC-1 on HIF-1α in a hepatocellular carcinoma cell line under hypoxic condition, which was generated by incubating cells with 0.1% O2. The phenotypic and molecular changes of cells were determined by cell proliferation assay, apoptosis assay, luciferase promoter assay, and Western blot analysis. YC-1 arrested tumor cell growth in a dose-dependent manner, whereas it did not induce cell apoptosis. Hypoxia-induced upregulation of HIF-1α was suppressed by YC-1 administration. YC-1 inhibited HIF-1α protein synthesis under normoxia and affected protein stability under hypoxia. YC-1 suppressed the expression of total and phosphorylated forms of murine double minute 2 (Mdm2), whereas this inhibitory effect was blocked by overexpression of Mdm2. In conclusion, YC-1 suppressed both protein synthesis and stability of HIF-1α in HCC cells, and its inhibitory effects on HIF-1α were dependent on Mdm2. © 2006 Elsevier Inc. All rights reserved.postprin

Fermi-lat Detection Of Pulsed Gamma-rays Above 50 Gev From The Vela Pulsar

published_or_final_versio

Problem-based learning : a teaching method to enhance learning experience for students in service-learning

Version of RecordPublishe

A Smart Card-Based Electronic School Absenteeism System for Influenza-Like Illness Surveillance in Hong Kong: Design, Implementation, and Feasibility Assessment

published_or_final_versio