India’s missing working women: Tracing the journey of women’s economic contribution over the last seven decades, and during COVID-19

India today is an economic powerhouse on the global stage. However, it faces a queer conundrum. Despite considerable gains in female education, decreases in fertility rates and increasing economic growth, only a fourth of its women are in the labor force, amongst the lowest in the world. Based on analysis of time series data over the last seven decades (1950-2018), this paper finds that women’s labor force and workforce participation rates have secularly declined to their lowest levels since Independence. Women’s wages have consistently been below men, with weighted average wage gaps increasing from 59% in 1993, to 72% in 2018. The fall in labor force participation has been led by women in rural areas, while female unemployment rates have remained higher than men in urban areas. We find that occupational segregation and concentration of women in low-growth sectors, income effect of rising household earnings, increased mechanization and gender gaps in tertiary education and skill training are leading factors behind the observed labor market outcomes. Recent high-frequency data shows that 15 million women lost their jobs in the first month of the COVID-19 induced lockdown. Even as the overall size of the labor force shrunk by 3% between November 2019 to November 2020, the size of the labor force shrunk by 13% for women, vs. 2% for men. Bringing women back to the workforce requires a differentiated approach, targeting different segments, especially informal workers, microentrepreneurs and the formal sector. Therefore, a diverse mix of targeted policy interventions like gender quotas in public works, easier access to credit for female micro-entrepreneurs, preferential procurement for women-owned business, greater flexibility in workplace arrangements and gender targets for skill training among others would help retain and promote workforce participation for women

Gut microbiota and microbiota-derived metabolites promotes endometriosis

Endometriosis is a pathological condition of the female reproductive tract characterized by the existence of endometrium-like tissue at ectopic sites, affecting 10% of women between the age 15 and 49 in the USA. However, currently there is no reliable non-invasive method to detect the presence of endometriosis without surgery and many women find hormonal therapy and surgery as ineffective in avoiding the recurrences. There is a lack of knowledge on the etiology and the factors that contribute to the development of endometriosis. A growing body of recent evidence suggests an association between gut microbiota and endometriosis pathophysiology. However, the direct impact of microbiota and microbiota-derived metabolites on the endometriosis disease progression is largely unknown. To understand the causal role of gut microbiota and endometriosis, we have implemented a novel model using antibiotic-induced microbiota-depleted (MD) mice to investigate the endometriosis disease progression. Interestingly, we found that MD mice showed reduced endometriotic lesion growth and, the transplantation of gut microbiota by oral gavage of feces from mice with endometriosis rescued the endometriotic lesion growth. Additionally, using germ-free donor mice, we indicated that the uterine microbiota is dispensable for endometriotic lesion growth in mice. Furthermore, we showed that gut microbiota modulates immune cell populations in the peritoneum of lesions-bearing mice. Finally, we found a novel signature of microbiota-derived metabolites that were significantly altered in feces of mice with endometriosis. Finally, we found one the altered metabolite, quinic acid promoted the survival of endometriotic epithelial cells in vitro and lesion growth in vivo, suggesting the disease-promoting potential of microbiota-derived metabolites. In summary, these data suggest that gut microbiota and microbiota-derived metabolome contribute to lesion growth in mice, possibly through immune cell adaptations. Of translational significance, these findings will aid in designing non-invasive diagnostics using stool metabolites for endometriosis

High-fat diets promote peritoneal inflammation and augment endometriosis-associated abdominal hyperalgesia

Immune dysfunction is one of the central components in the development and progression of endometriosis by establishing a chronic inflammatory environment. Western-style high-fat diets (HFD) have been linked to greater systemic inflammation to cause metabolic and chronic inflammatory diseases, and are also considered an environmental risk factor for gynecologic diseases. Here, we aimed to examine how HFD cause an inflammatory environment in endometriosis and discern their contribution to endometriotic-associated hyperalgesia. Our results showed that HFD-induced obesity enhanced abdominal hyperalgesia that was induced by endometriotic lesions. Peritoneal inflammatory macrophages and cytokine levels increased by lesion induction were elevated by chronic exposure to HFD. Increased expression of pain-related mediators in the dorsal root ganglia was observed after lesion induction under the HFD condition. Although HFD did not affect inflammatory macrophages in the peritoneal cavity without lesion induction, the diversity and composition of the gut microbiota were clearly altered by HFD as a sign of low-grade systemic inflammation. Thus, HFD alone might not establish a local inflammatory environment in the pelvic cavity, but it can contribute to further enhancing chronic inflammation, leading to the exacerbation of endometriosis-associated abdominal hyperalgesia following the establishment and progression of the disease

Microbial Ecology of Sulfur Biogeochemical Cycling at a Mesothermal Hot Spring Atop Northern Himalayas, India

International audienceSulfur related prokaryotes residing in hot spring present good opportunity for exploring the limitless possibilities of integral ecosystem processes. Metagenomic analysis further expands the phylogenetic breadth of these extraordinary sulfur (S) metabolizing microorganisms as well as their complex metabolic networks and syntrophic interactions in environmental biosystems. Through this study, we explored and expanded the microbial genetic repertoire with focus on S cycling genes through metagenomic analysis of S contaminated hot spring, located at the Northern Himalayas. The analysis revealed rich diversity of microbial consortia with established roles in S cycling such as Pseudomonas , Thioalkalivibrio , Desulfovibrio , and Desulfobulbaceae ( Proteobacteria ). The major gene families inferred to be abundant across microbial mat, sediment, and water were assigned to Proteobacteria as reflected from the reads per kilobase (RPKs) categorized into translation and ribosomal structure and biogenesis. An analysis of sequence similarity showed conserved pattern of both dsrAB genes ( n = 178) retrieved from all metagenomes while other S disproportionation proteins were diverged due to different structural and chemical substrates. The diversity of S oxidizing bacteria (SOB) and sulfate reducing bacteria (SRB) with conserved (r) dsrAB suggests for it to be an important adaptation for microbial fitness at this site. Here, (i) the oxidative and reductive dsr evolutionary time–scale phylogeny proved that the earliest (but not the first) dsrAB proteins belong to anaerobic Thiobacillus with other ( rdsr ) oxidizers, also we confirm that (ii) SRBs belongs to δ- Proteobacteria occurring independent lateral gene transfer (LGT) of dsr genes to different and few novel lineages. Further, the structural prediction of unassigned DsrAB proteins confirmed their relatedness with species of Desulfovibrio (TM score = 0.86, 0.98, 0.96) and Archaeoglobus fulgidus (TM score = 0.97, 0.98). We proposed that the genetic repertoire might provide the basis of studying time–scale evolution and horizontal gene transfer of these genes in biogeochemical S cycling

India’s missing working women: tracing the journey of women’s economic contribution over the last seven decades, and during COVID-19

India today is an economic powerhouse on the global stage. However, it faces a queer conundrum. Despite considerable gains in female education, decreases in fertility rates and increasing economic growth, only a fourth of its women are in the labor force, amongst the lowest in the world. Based on analysis of time series data over the last seven decades (1950-2018), this paper finds that women’s labor force and workforce participation rates have secularly declined to their lowest levels since Independence. Women’s wages have consistently been below men, with weighted average wage gaps increasing from 59% in 1993, to 72% in 2018. The fall in labor force participation has been led by women in rural areas, while female unemployment rates have remained higher than men in urban areas. We find that occupational segregation and concentration of women in low-growth sectors, income effect of rising household earnings, increased mechanization and gender gaps in tertiary education and skill training are leading factors behind the observed labor market outcomes. Recent high-frequency data shows that 15 million women lost their jobs in the first month of the COVID-19 induced lockdown. Even as the overall size of the labor force shrunk by 3% between November 2019 to November 2020, the size of the labor force shrunk by 13% for women, vs. 2% for men. Bringing women back to the workforce requires a differentiated approach, targeting different segments, especially informal workers, microentrepreneurs and the formal sector. Therefore, a diverse mix o