A preliminary study on perioperative hemostatic effect of spray dried powder of <i>Chromolaena odorata</i> leaf extract

547-555Accidents or surgery often cause internal haemorrhage in liver and arteries which may lead to patient morbidity and mortality. The current hemostatic agents used for treatment like collagen, oxidized cellulose, and chitosan suffer from side effects which include infection, inflammation and even sepsis. In the present study, we studied the spray dried powder (SDP) of the aqueous extract of the leaves of Chromolaena odorata (L.) R.M.King & H.Rob., commonly known as Siam weed or Common floss flower and also Christmas bush, for its hemostatic efficacy in two experimental models of surgery. Firstly, the SDP was screened through standard pharmacognostical parameters, and a part of the liver was lacerated in rats and femoral artery was transected in rabbits to assess the blood loss in pre-weighed gauze with and without treatment. In the liver laceration model, an effective blood loss reduction of 54.30 % was observed with oral administration of SDP 7 days prior to surgery. Similarly, application of SDP at the site of artery transection caused 70.36% reduction in blood loss as compared to the control rabbit artery. The results suggest that oral delivery and/or application of SDP of C. odorata by formulating it in a suitable drug delivery tool could minimize perioperative bleeding in hepatic and arterial tissue and improve recovery

Preferentially oriented m-tuned WO3 thin-films photocatalysts for the multitargeted degradation of organic molecules

In this work, morphology-tuned tungsten oxide (m-tuned WO3) thin films are deposited on a glass substrate by a simple and cost-effective chemical bath deposition (CBD) method. The deposition pH is varied to tune the physicochemical properties of m-tuned WO3 thin films. The m-tuned WO3 thin films show an orthorhombic crystal structure with a preferred orientation along the (020) plane. The morphological study demonstrated the conversion of ‘rice hull’ to ‘interlocked nanosheets’ to ‘reticulated nanosheets composed of nanorods’ upon changing pH, highlighting the significant role of pH in m-tuned WO3 thin film synthesis. The m-tuned WO3 thin films show good absorption in the visible-light region (390–780 nm) of the solar spectrum. The m-tuned WO3 thin films are used for the visible light active photocatalytic degradation of organic molecules such as methylene blue (MB), rhodamine B (Rh B), and tetracycline hydrochloride (TC). The optimized m-tuned WO3 thin film shows maximum photocatalytic performance of 95, 94, and 86 % in 180 min for MB, Rh B, and TC, respectively. The present study demonstrates the usefulness of the CBD method for the deposition of m-tuned WO3 and improved photocatalytic performance