Evaluation of Right Ventricular overload by ^<123>I-MIBG, ^<123>I-BMIPP , and ^<99m>Tc-MIBI

It is important to evaluate the severity of right ventricular (RV) overload in patients with chronic pulmonary diseases or pulmonary thromboembolism because their prognosis depend on the severity of RV overload. Various examination methods have been used to non-invasively evaluate the severity of RV overload. We evaluated the usefulness of recently developed novel radiopharmaceuticals 123I-MIBG, 123I-BMIPP, and 99mTc-MIBI) in patients with chronic respiratory diseases or pulmonary thromboembolism. Myocardial scintigraphy using 1231-MIBG revealed that the ratio of scintillation counts in the interventricular septum (IVS) to those in the left ventricle (LV) correlated negatively with the mean pulmonary arterial pressure (MPAP), suggesting the presence of sympathetic neuropathy due to RV overload. Myocardial scintigraphy using 123I-BMIPP revealed that the ratio of scintillation counts in the RV to those in LV (RV/LV uptake ratio) correlated with MPAP. There was a negative correlation between RV metabolic index [RVMI = (RV/LV ratio of 123I-BMIPP uptake)(RV/LV ratio of 201T1 uptake)] and MPAP. These findings suggested the presence of RV overload-induced fatty acid metabolic disorder. 99iTc-MIBI allows the simultaneous performance of both cardiac pool scintigraphy and myocardial single photon emission computed tomography. RV/LV ratio of 99Tc-MIBI uptake correlated with MPAP. Moreover, RV ejection fraction (RVEF) obtained by right cardiac pool scintigraphy correlated with the RVEF determined by the thermodilution method, suggesting the usefulness of 99mTc-MIBI. Our findings suggest that these radiopharmaceuticals are useful for evaluating the severity of RV overload in patients with chronic respiratory diseases or pulmonary thromboembolism, as well as for evaluating RV overloadinduced metabolic disorders

Bone fragility via degradation of bone quality featured by collagen/apatite micro-arrangement in human rheumatic arthritis

Although increased bone fragility is a well-recognized consequence in patients with rheumatoid arthritis (RA), the essential cause of degenerate bone strength remains unknown. This study aimed to determine factors contributing to bone dysfunction in RA by focusing on the bone matrix micro-arrangement, based on the preferential orientation of collagen and the related apatite c-axis as a bone quality index. The classical understanding of RA is limited to its severe pathological conditions associated with inflammation-induced bone loss. This study examined periarticular proximal tibiae from RA patients as compared with osteoarthritis (OA) patients as controls. Bone tissue material strength was disrupted in the RA group compared with the control. Collagen/apatite micro-arrangement and vBMD were significantly lower in the RA group, and the rate of decrease in apatite c-axis orientation (−45%) was larger than that in vBMD (−22%). Multiple regression analysis showed that the degree of apatite c-axis orientation (β = 0.52, p = 1.9 × 10−2) significantly contributed to RA-induced bone material impairment as well as vBMD (β = 0.46, p = 3.8 × 10−2). To the best of our knowledge, this is the first report to demonstrate that RA reduces bone material strength by deteriorating the micro-arrangement of collagen/apatite bone matrix, leading to decreased fracture resistance. Our findings represent the significance of bone quality-based analysis for precise evaluation and subsequent therapy of the integrity and soundness of the bone in patients with RA.Ozasa R., Matsugaki A., Ishimoto T., et al. Bone fragility via degradation of bone quality featured by collagen/apatite micro-arrangement in human rheumatic arthritis. Bone, 155, 116261. https://doi.org/10.1016/j.bone.2021.116261

Metal-semiconductor transition like behavior of naphthalene-doped single wall carbon nanotube bundles

Accepted 27 Jun 2014Naphthalene (N) or naphthalene-derivative (ND) adsorption-treatment evidently varies the electrical conductivity of single wall carbon nanotube (SWCNT) bundles over a wide temperature range due to a charge-transfer interaction. The adsorption treatment of SWCNTs with dinitronaphthalene molecules enhances the electrical conductivity of the SWCNT bundles by 50 times. The temperature dependence of the electrical conductivity of N- or ND-adsorbed SWCNT bundles having a superlattice structure suggests metal-semiconductor transition like behavior near 260 K. The ND-adsorbed SWCNT gives a maximum in the logarithm of electrical conductivity vs. T-1. plot, which may occur after the change to a metallic state and be associated with a partial unravelling of the SWCNT bundle due to an evoked librational motion of the moieties of ND with elevation of the temperature.ArticleFARADAY DISCUSSIONS. 173:145-156 (2014)journal articl

熊本DPATにおける精神保健福祉士の活動と視座 : フェーズ3・4におけるロジステイクスとしての役割と新たな可能性

In this research, the purpose was to analyze the knowledge, skills, value ethics, and difficulties in DPAT activities used by Logistics (Psychiatric Social worker: PSW) who conducted DPAT activities. The voice data obtained by the interview survey were analyzed and considered by the qualitative research method. As a result, seven categories were extracted for "expertise of PSW effectively used as Logistics in DPAT", and its structure was tried. In addition, four categories were extracted for "the difficulty in performing Logistics activities in DPAT as PSW", and the structure was tried. From these results, it became clear that PSW, which carried out DPAT activities, crossed the border its role as logistics and demonstrated its expertise. On the other hand, it also became clear that they had various difficulties. Furthermore, PSW placed "a viewpoint that captures the overall relationship between people and situations" at the core of that perspective. By taking advantage of such specialties, PSW has been objecting to "the role of PSW as Logistics". And, it was suggested that PSW had new possibilities when fulfilling its duties as Logistics

Developing a short-term phenomenological training program: A report of methodological lessons

2020 Elsevier Ltd We discuss our attempts to develop a short-term phenomenological training program for training naïve participants in phenomenological skills. After reviewing existing methodologies for collecting phenomenological data and clarifying the benefit of the short-term training approach, we present two training programs and two experiments that tested their effectiveness. Experiment 1 tested the two-stage training program, which consists of (i) the illusion training which instructs participants to describe the experience of a visual illusion and (ii) the guidance training which offers individualized feedbacks for improving their description. This program proved effective, but also excessively skill-demanding. Experiment 2 tested the one-stage training program, consisting only of the illusion training; it was easier to use, but exhibited a smaller training effect. The paper concludes by delineating methodological lessons from the experiments focusing on three themes: (i) Individual difference in phenomenological aptitude; (ii) Bounded transferability of phenomenological skills; (iii) Active intervention in the learning process

Developing a short-term phenomenological training program: A report of methodological lessons

We discuss our attempts to develop a short-term phenomenological training program for training naïve participants in phenomenological skills. After reviewing existing methodologies for collecting phenomenological data and clarifying the benefit of the short-term training approach, we present two training programs and two experiments that tested their effectiveness. Experiment 1 tested the two-stage training program, which consists of (i) the illusion training which instructs participants to describe the experience of a visual illusion and (ii) the guidance training which offers individualized feedbacks for improving their description. This program proved effective, but also excessively skill-demanding. Experiment 2 tested the one-stage training program, consisting only of the illusion training; it was easier to use, but exhibited a smaller training effect. The paper concludes by delineating methodological lessons from the experiments focusing on three themes: (i) Individual difference in phenomenological aptitude; (ii) Bounded transferability of phenomenological skills; (iii) Active intervention in the learning process

Functions of consciousness : conceptual clarification

There are many theories of the functions of consciousness. How these theories relate to each other, how we should assess them, and whether any integration of them is possible are all issues that remain unclear. To contribute to a solution, this paper offers a conceptual framework to clarify the theories of the functions of consciousness. This framework consists of three dimensions: (i) target, (ii) explanatory order, and (iii) necessity/sufficiency. The first dimension, target, clarifies each theory in terms of the kind of consciousness it targets. The second dimension, explanatory order, clarifies each theory in terms of how it conceives of the explanatory relation between consciousness and function. The third dimension, necessity/sufficiency, clarifies each theory in terms of the necessity/sufficiency relation posited between consciousness and function. We demonstrate the usefulness of this framework by applying it to some existing scientific and philosophical theories of the functions of consciousness