A case of scleritis associated rheumatoid arthritis accompanying an intraocular elevated lesion

Abstract Background Scleritis and/or uveitis sometimes accompanies patients who suffer from rheumatoid arthritis. However, few studies have reported scleritis and/or uveitis accompanying a fundus elevated lesion, such as an intraocular tumor. In this study, we report a case of rheumatoid uveitis associated with an intraocular elevated lesion. Case presentation A 66-year-old female visited another eye clinic and was diagnosed as bilateral anterior uveitis, and was prescribed steroid eye drops for treatment. She had previously been diagnosed as rheumatoid arthritis at the age of 30 years. Due to vitreous opacity that appeared in her right eye, we increased the instillation of steroid eye drops and the amount of oral prednisolone. Although the inflammation had improved, anterior uveitis relapsed, and an intraocular whitish elevated lesion resembling an intraocular tumor at the superior nasal retina appeared. We speculated this lesion to be a granuloma complicated with rheumatoid arthritis. Thus, we increased the amount of prednisolone administration, and the lesion began to shrink and ultimately fully disappeared. Conclusions We strongly believe that our case’s lesion was a subretinal granuloma related with rheumatoid arthritis, as it disappeared by increased corticosteroid treatment. Our findings show that we should consider rheumatoid arthritis in a differential diagnosis of such types of fundus elevated lesions

Quantitative Trait Loci (QTL) Associated with Resistance to a Monogenean Parasite (<i>Benedenia seriolae</i>) in Yellowtail (<i>Seriola quinqueradiata</i>) through Genome Wide Analysis

<div><p>Benedenia infections caused by the monogenean fluke ectoparasite <i>Benedenia seriolae</i> seriously impact marine finfish aquaculture. Genetic variation has been inferred to play a significant role in determining the susceptibility to this parasitic disease. To evaluate the genetic basis of Benedenia disease resistance in yellowtail (<i>Seriola quinqueradiata</i>), a genome-wide and chromosome-wide linkage analyses were initiated using F₁ yellowtail families (n = 90 per family) based on a high-density linkage map with 860 microsatellite and 142 single nucleotide polymorphism (SNP) markers. Two major quantitative trait loci (QTL) regions on linkage groups Squ2 (<i>BDR-1</i>) and Squ20 (<i>BDR-2</i>) were identified. These QTL regions explained 32.9–35.5% of the phenotypic variance. On the other hand, we investigated the relationship between QTL for susceptibility to <i>B. seriolae</i> and QTL for fish body size. The QTL related to growth was found on another linkage group (Squ7). As a result, this is the first genetic evidence that contributes to detailing phenotypic resistance to Benedenia disease, and the results will help resolve the mechanism of resistance to this important parasitic infection of yellowtail.</p></div

Localization of significant markers for Benedenia disease resistance in linkage group Squ2F and Squ20F with family A.

<p>Squ(linkage group)F; marker distance in female map. (A) Squ2F, (B) Squ20F. Map positions and LOD scores are based on a simple interval mapping QTL analysis using the software MapQTL 5. Marker absolute map distances are given in (cM). 95% confidence probability LOD support interval was indicated as Gray bold line. Horizontal lines across each plot indicate LOD siginificance threshold, <i>P_g</i>; genome-wide significance threshold.</p

Between fish size and number of parasites in pairwise Pearson correlations.

<p>Values in bold are different from a significance level <i>P</i> = 0.001.</p

Simple interval mapping results of the fish sizes in linkage group 7 and 17 in family A.

<p>Locus; marker name, LOD; Lod scores, % Var; percent of variance explained. Effect; estimated effect. Squ(linkage group)F; F is dam allele in female linkage group. Values in bold are LOD max in peak of each QTL, marker position and each value.</p

Significant markers for Benedenia disease resistance multiple-QTL model mapping in linkage group Squ2F and Squ20F with family A.

<p>Squ(linkage group)F; marker distance in female map. (A) Squ2F, (B) Squ20F. This figure was described using by MapQTL 5.</p

Multiple QTL model mapping results of the significant markers for Benedenia disease resistance in linkage group 2 and 20 in family A.

<p>Locus; marker name, LOD; Lod scores, % Var; percent of variance explained, Effect; estimated effect. Squ(linkage group)F; F is dam allele in female linkage group. Values in bold are LOD max in peak of each QTL marker position and each value.</p

Significant markers for Benedenia disease resistance using Kruskal–Wallis analysis with A and B families.

<p>Signif.; Significance levels:</p>*<p><0.1</p>**<p><0.05</p>***<p><0.01</p>****<p><0.005</p>*****<p><0.001</p>******<p><0.0005</p>*******<p><0.0001.</p><p>NS; not significant, -; not informative in this locus.</p><p>Squ(linkage group)F; F is dam allele in female linkage group. Squ(linkage group)M; M is sire allele in male linkage group.</p