A New 100-GHz Band Front-End System with a Waveguide-Type Dual-Polarization Sideband-Separating SIS Receiver for the NRO 45-m Radio Telescope

We developed a waveguide-type dual-polarization sideband-separating SIS receiver system of the 100-GHz band for the 45-m radio telescope at the Nobeyama Radio Observatory, Japan. This receiver is composed of an ortho-mode transducer and two sideband-separating SIS mixers, which are both based on the waveguide technique. The receiver has four intermediate frequency bands of 4.0--8.0 GHz. Over the radio frequency range of 80--120 GHz, the single-sideband receiver noise temperatures are 50--100 K and the image rejection ratios are greater than 10 dB. We developed new matching optics for the telescope beam as well as new IF chains for the four IF signals. The new receiver system was installed in the telescope, and we successfully observed the 12CO, 13CO and C18O emission lines simultaneously toward the Sagittarius B2 region to confirm the performance of the receiver system. The SSB noise temperature of the system, including the atmosphere, became approximately half of that of the previous receiver system. The Image Rejection Ratios (IRRs) of the two 2SB mixers were calculated from the 12CO and HCO+ spectra from the W51 giant molecular cloud, resulting in > 20 dB for one polarization and > 12 dB for the other polarization.Comment: 10 pages, 13 figures, Accepted for publication in PASJ, version with high resolution figures is available via http://www.nro.nao.ac.jp/library/report/list.htm

A Pilot Study: The Beneficial Effects of Combined Statin-exercise Therapy on Cognitive Function in Patients with Coronary Artery Disease and Mild Cognitive Decline.

Objective Hypercholesterolemia, a risk factor in cognitive impairment, can be treated with statins. However, cognitive decline associated with "statins" (HMG-CoA reductase inhibitors) is a clinical concern. This pilot study investigated the effects of combining statins and regular exercise on cognitive function in coronary artery disease (CAD) patients with prior mild cognitive decline. Methods We recruited 43 consecutive CAD patients with mild cognitive decline. These patients were treated with a statin and weekly in-hospital aerobic exercise for 5 months. We measured serum lipids, exercise capacity, and cognitive function using the mini mental state examination (MMSE). Results Low-density lipoprotein cholesterol levels were significantly decreased, and maximum exercise capacity (workload) was significantly increased in patients with CAD and mild cognitive decline after treatment compared with before. Combined statin-exercise therapy significantly increased the median (range) MMSE score from 24 (22-25) to 25 (23-27) across the cohort (p<0.01). Changes in body mass index (BMI) were significantly and negatively correlated with changes in the MMSE. After treatment, MMSE scores in the subgroup of patients that showed a decrease in BMI were significantly improved, but not in the BMI-increased subgroup. Furthermore, the patients already on a statin at the beginning of the trial displayed a more significant improvement in MMSE score than statin-naïve patients, implying that exercise might be the beneficial aspect of this intervention as regards cognition. In a multivariate logistic regression analysis adjusted for age >65 years, sex, and presence of diabetes mellitus, a decrease in BMI during statin-exercise therapy was significantly correlated with an increase in the MMSE score (odds ratio: 4.57, 95% confidence interval: 1.05-20.0; p<0.05). Conclusion Statin-exercise therapy may help improve cognitive dysfunction in patients with CAD and pre-existing mild cognitive decline

New 60-cm Radio Survey Telescope with the Sideband-Separating SIS Receiver for the 200 GHz Band

We have upgraded the 60-cm radio survey telescope located in Nobeyama, Japan. We developed a new waveguide-type sideband-separating SIS mixer for the telescope, which enables the simultaneous detection of distinct molecular emission lines both in the upper and lower sidebands. Over the RF frequency range of 205-240 GHz, the single-sideband receiver noise temperatures of the new mixer are 40-100 K for the 4.0-8.0 GHz IF frequency band. The image rejection ratios are greater than 10 dB over the same range. For the dual IF signals obtained by the receiver, we have developed two sets of acousto-optical spectrometers and a telescope control system. Using the new telescope system, we successfully detected the 12CO (J=2-1) and 13CO (J=2-1) emission lines simultaneously toward Orion KL in 2005 March. Using the waveguide-type sideband-separating SIS mixer for the 200 GHz band, we have initiated the first simultaneous 12CO (J=2-1) and 13CO (J=2-1) survey of the galactic plane as well as large-scale mapping observations of nearby molecular clouds.Comment: 15 pages, 15 figures, Accepted for publication in PASJ, version with high resolution figures is available via http://www.nro.nao.ac.jp/~nakajima/vst1_2sb.pd

BALB/c-Fcgr2b−/−Pdcd1−/− mouse expressing anti-urothelial antibody is a novel model of autoimmune cystitis

We report the impact of anti-urothelial autoantibody (AUAb) on urinary bladder phenotype in BALB/c mice deficient of the FcγRIIb and PD-1. AUAb was present in serum samples from approximately half of the double-knockout (DKO) mice, as detected by immunofluorescence and immunoblots for urothelial proteins including uroplakin IIIa. The AUAb-positive DKO mice showed degeneration of urothelial plaque and umbrella cells, along with infiltration of inflammatory cells in the suburothelial layer. TNFα and IL-1β were upregulated in the bladder and the urine of AUAb-positive DKO mice. Voiding behavior of mice was analyzed by the Voided Stain on Paper method. 10-week-old and older AUAb-positive DKO mice voided significantly less urine per void than did wild type (WT) mice. Furthermore, administration of the AUAb-containing serum to WT mice significantly reduced their urine volume per void. In summary, this report presents a novel comprehensive mouse model of autoimmune cystitis

The AMANOGAWA-2SB Galactic Plane Survey I: Data on the Galactic Equator

Using a waveguide-type sideband-separating receiver (2SB receiver) on the Tokyo-NRO 60-cm telescope (renamed the AMANOGAWA telescope), we carried out simultaneous observations in the 12CO(J = 2-1) and 13CO(J = 2-1) lines over the Galactic plane l = 10-245 deg along b = 0 deg with a 3.75 arcmin grid. Using the 12CO(J = 1-0) data of Dame et al. (2001), who used a beam size almost the same as ours, we show 12CO(J = 2-1)/12CO(J = 1-0) and 13CO(J = 2-1)/12CO(J = 2-1) intensity ratios on the l-v map and the intensity correlations among the three lines. As a result, a linear correlation between 12CO(J = 1-0) and 12CO(J = 2-1) and a curve correlation between 12CO(J = 2-1) and 13CO(J = 2-1), as produced by most of the data, are found. We investigate these correlations with simple radiative transfer equations to ascertain a number of restrictions on the physical quantities of molecular gas on a galactic scale.Comment: 22 pages, 13 figures, accepted for publication in PAS

Aortic Dissection in a Patient with Human Immunodeficiency Virus Infection That was Diagnosed at Autopsy : A Case Report.

A 43-year-old homosexual man was referred to our hospital for chest pain and loss of consciousness. He was hypertensive, and had an uncontrolled viral load. Serum creatinine revealed acute renal failure, and he died 3 days later. On autopsy, aortic dissection (TypeB) was found. No obvious inflammatory change, granulation, bacterial or fungal infection, or medionecrosis were seen at the dissection site. To our knowledge, this was the first case with HIV in whom aortic dissection was diagnosed at autopsy. Aortic dissection is a potential differential diagnosis even in young patients presenting with hypertension and chest pain