64 research outputs found

    Crow-Fukase syndrome associated with high-output heart failure

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    金沢大学医薬保健研究域医学系A 64-year-old woman was admitted with systemic edema and exertional dyspnea. High-output heart failure was diagnosed by right heart catheterization and she was treated with diuretics. After 3 weeks, her symptoms disappeared but a high cardiac output state persisted. A diagnosis of Crow-Fukase syndrome was made based on the presence of polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes. Her serum vascular endothelial growth factor (VEGF) level was markedly elevated after recovery from heart failure. We suspect that an elevated VEGF level and a high cardiac output state may play a role in the pathogenesis of heart failure in Crow-Fukase syndrome

    Impaired Negative Selection of T Cells in Hodgkin's Disease Antigen CD30–Deficient Mice

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    AbstractCD30 is found on Reed–Sternberg cells of Hodgkin's disease and on a variety of non-Hodgkin's lymphoma cells and is up-regulated on cells after Epstein–Barr virus, human T cell leukemia virus, and HIV infections. We report here that the thymus in CD30-deficient mice contains elevated numbers of thymocytes. Activation-induced death of thymocytes after CD3 cross-linking is impaired both in vitro and in vivo. Breeding the CD30 mutation separately into αβTCR- or γδTCR-transgenic mice revealed a gross defect in negative but not positive selection. Thus, like TNF-receptors and Fas/Apo-1, the CD30 receptor is involved in cell death signaling. It is also an important coreceptor that participates in thymic deletion

    The Transcription Factor NF-ATc1 Regulates Lymphocyte Proliferation and Th2 Cytokine Production

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    AbstractNF-ATc1 is a member of a family of genes that encodes the cytoplasmic component of the nuclear factor of activated T cells (NF-AT). In activated T cells, nuclear NF-AT binds to the promoter regions of multiple cytokine genes and induces their transcription. The role of NF-ATc1 was investigated in recombination activating gene-1 (RAG-1)–deficient blastocyst complementation assays using homozygous NF-ATc1−/− mutant ES cell lines. NF-ATc1−/−/RAG-1−/− chimeric mice showed reduced numbers of thymocytes and impaired proliferation of peripheral lymphocytes, but normal production of IL-2. Induction in vitro of Th2 responses, as demonstrated by a decrease in IL-4 and IL-6 production, was impaired in mutant T cells. These data indicate that NF-ATc1 plays roles in the development of T lymphocytes and in the differentiation of the Th2 response

    Emergent Rank-5 'Nematic' Order in URu2Si2

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    Novel electronic states resulting from entangled spin and orbital degrees of freedom are hallmarks of strongly correlated f-electron systems. A spectacular example is the so-called 'hidden-order' phase transition in the heavy-electron metal URu2Si2, which is characterized by the huge amount of entropy lost at T_{HO}=17.5K. However, no evidence of magnetic/structural phase transition has been found below T_{HO} so far. The origin of the hidden-order phase transition has been a long-standing mystery in condensed matter physics. Here, based on a first-principles theoretical approach, we examine the complete set of multipole correlations allowed in this material. The results uncover that the hidden-order parameter is a rank-5 multipole (dotriacontapole) order with 'nematic' E^- symmetry, which exhibits staggered pseudospin moments along the [110] direction. This naturally provides comprehensive explanations of all key features in the hidden-order phase including anisotropic magnetic excitations, nearly degenerate antiferromagnetic-ordered state, and spontaneous rotational-symmetry breaking.Comment: See the published version with more detailed discussion

    長崎国際大学生における食生活の現状と骨密度の関係

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    日本人はカルシウムの摂取量が慢性的に不足していることから、骨粗鬆症、骨軟化症、さらにくる病などの骨関連疾患が大きな問題となっている。一方で、その予防には食生活が重要性な要因であると認識されている。そこで今回、大学生の生活状況を調査するため、骨形成に関与する栄養素に注目し、長崎国際大学健康管理学部健康栄養学科で実施されている「健康栄養調査プロジェクト」の結果を解析した。男子学生のカルシウム(Ca)摂取量は、目標量(650mg/日)をほぼ満たす量(647±79mg/日)であったが、女子学生の Ca 摂取量(480±11mg/日)は目標量(600mg/日)の80%と不足していた。食品群別にみると、女子学生においてミネラル分が豊富な海藻類、小魚の摂取頻度が少なく、このことが女子学生でみられた Ca 摂取不足の主たる原因と考えられた。また、牛乳の摂取頻度が週7回以上の群は、7回未満の群に比べ骨密度の高い傾向がみられ、このことから若年期においても牛乳の摂取頻度が骨密度に影響している可能性が示唆された。Japanese people is chronically low level of calcium ingestion, therefore it is increased disorders related bone, osteoporosis, osteomalacia, rickets and other. On the other hand their prevention is closely related to dietary habit. In this study, to see about dietary habit on young people, we analyzed the result of "The Health and Nutritional Survey Project" conducted in Department of Health and Nutrition, Faculty of Health Management, Nagasaki International University about nutrient factor relative to bone formation. The calcium ingestion on male students (647±79mg/day) was close on tentative dietary goal for preventing life-style related diseases (DG) (650mg/day) by dietary reference intakes for Japanese [2005]. But calcium ingestion on female students (480±11mg/day) was lower, about 80% compared with DG (600mg). From the results of food group frequency, this low level of calcium ingestion on female students is likely to be caused by that frequency of sea vegetable and fingerling was few. And bone density evaluation was significantly high in group over 7 times/week compared with group below 7 times/week about frequency of milk. This result suggests that frequency of milk has an affect on bone density in early life

    学生の健康及び食生活意識と血液検査値の関係に対する一考察 - 健康栄養調査プロジェクト報告 第2報 -

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    長崎国際大学健康管理学部健康栄養学科に所属する学生を対象に平成17年度に実施した「健康栄養プロジェクト」の結果のうち、学生(男子43名、女子285名)の食生活意識、身体状況および血液生化学検査(総コレステロール、トリアシルグリセロール、ヘモグロビン A1c、血清鉄)の関係について検討を加えた。その結果、欠食頻度が高い者ほど疲労愁訴を有する割合が高くなる傾向があった。また、欠食回数及び食生活意識と血液生化学検査値との関係に男女差が見られた。男子学生では欠食がある場合は検査値が低くなる傾向がみられたが、女子学生では欠食が無いにもかかわらず低値を示す者が多かった。このことから、今後食生活指導を行う際には、食事内容を具体的に把握し、適正な食事量を認識させる重要性が示唆された。This study, "The Health and Nutrition Survey Project" for the undergraduates (43 males and 285 females) who belong to the department of health and nutrition in Nagasaki International University, was examined to grasp their life style, physical condition, eating-habits consciousness and blood biochemical levels. We focused on their physical condition, eating-habits, especially skipping-a-meal and some blood biochemical levels (total cholesterol, triacylglycerol, hemoglobin A1c and serum iron). First of all, the complaint of physical fatigue is more on much skipping-a-meal undergraduates. Moreover, the relation the times of skipping a meal and some blood biochemical levels was different between male and female. In male undergraduates, triacylglycerol and hemoglobin A1c levels were lower on skipping a meal. In female undergraduates, although no skipping a meal, much low total cholesterol, triacylglycerol, hemoglobin A1c and serum iron levels had shown on. It was suggested we have to instruct the proper amount of meals in them, grasping not only the habit of skipping-a-meal, but also concretely their meal contents
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