Large-System Analysis of Joint Channel and Data Estimation for MIMO DS-CDMA Systems

This paper presents a large-system analysis of the performance of joint channel estimation, multiuser detection, and per-user decoding (CE-MUDD) for randomly-spread multiple-input multiple-output (MIMO) direct-sequence code-division multiple-access (DS-CDMA) systems. A suboptimal receiver based on successive decoding in conjunction with linear minimum mean-squared error (LMMSE) channel estimation is investigated. The replica method, developed in statistical mechanics, is used to evaluate the performance in the large-system limit, where the number of users and the spreading factor tend to infinity while their ratio and the number of transmit and receive antennas are kept constant. The performance of the joint CE-MUDD based on LMMSE channel estimation is compared to the spectral efficiencies of several receivers based on one-shot LMMSE channel estimation, in which the decoded data symbols are not utilized to refine the initial channel estimates. The results imply that the use of joint CE-MUDD significantly reduces rate loss due to transmission of pilot signals, especially for multiple-antenna systems. As a result, joint CE-MUDD can provide significant performance gains, compared to the receivers based on one-shot channel estimation.Comment: The paper was resubmitted to IEEE Trans. Inf. Theor

Processing of mutated proinsulin with tetrabasic cleavage sites to bioactive insulin in the non-endocrine cell line, COS-7

AbstractThe amino acid sequence, Arg−4-X−3-Lys/Arg−2-Arg−1 ↓ X+1, is thought to be a consensus processing site for a constitutive secretory pathway in non-endocrine cells. We created a mutant proinsulin DNA with a peptide structure of B chain-Arg-Arg-Lys-Arg-C peptide-Arg-Arg-Lys-Arg-A chain, which compares to the native proinsulin structure of B chain-Arg-Arg-C peptide-Lys-Arg-A chain. When the mutant insulin was expressed in a monkey kidney-derived cell line, COS-7, approximately 60% of the total immunoreactive insulin appeared as mature insulin in the culture medium. This conversion to the mature form was strikingly facilitated by co-expressing the mutant proinsulin with furin, a homologue of the yeast endoprotease, Kex2

Iridium complex, a phosphorescent light-emitting diode material, serves as a novel chemical probe for imaging hypoxic tumor tissues

Iridium complex, a promising organic light-emitting diode for next generation television displays, emits phosphorescence. Phosphorescence is quenched by oxygen. We used this oxygen-quenching feature for imaging tumor hypoxia. Red light-emitting iridium complex Ir(btp)~2~(acac) (BTP) presented hypoxia-dependent light emission in culture cell lines, whose intensity was in parallel with HIF-1[alpha] expression. BTP was further applied to imaging five tumors (four from human origin and one from mouse origin) transplanted in athymic mice. All tumors presented a bright BTP-emitting image even 5 min after the injection. The BTP-dependent tumor image peaked at 1 to 2 h after the injection, and was then cleared from tumors within 24 h. The minimal BTP image recognition size was 3 to 4 mm in diameter. Compared with ^18^F-FDG/PET images, BTP delineated a clearer image for a tumor profile. We suggest that iridium complex has a vast potential for imaging hypoxic lesions such as tumor tissues