Infrared 3-4 Micron Spectroscopy of Nearby PG QSOs and AGN-Nuclear Starburst Connections in High-luminosity AGN Populations

We present the results of infrared L-band (3-4 micron) slit spectroscopy of 30 PG QSOs at z < 0.17, the representative sample of local high-luminosity, optically selected AGNs. The 3.3 micron polycyclic aromatic hydrocarbon (PAH) emission feature is used to probe nuclear (< a few kpc) starburst activity and to investigate the connections between AGNs and nuclear starbursts in PG QSOs. The 3.3 micron PAH emission is detected in the individual spectra of 5/30 of the observed PG QSOs. We construct a composite spectrum of PAH-undetected PG QSOs and discern the presence of the 3.3 micron PAH emission therein. We estimate the nuclear-starburst and AGN luminosities from the observed 3.3 micron PAH emission and 3.35 micron continuum luminosities, respectively, and find that the nuclear-starburst-to-AGN luminosity ratios in PG QSOs are similar to those of previously studied AGN populations with lower luminosities, suggesting that AGN-nuclear starburst connections are valid over the wide luminosity range of AGNs in the local universe. The observed nuclear-starburst-to-AGN luminosity ratios in PG QSOs with available supermassive black hole masses are comparable to a theoretical prediction based on the assumption that the growth of a supermassive black hole is controlled by starburst-induced turbulence.Comment: 10 pages, 5 figures, accepted for publication in PASJ (No. 63, 2011 March, Subaru special issue

Neuromedin U-deficient rats do not lose body weight or food intake

Studies in genetically modified mice establish that essential roles of endogenous neuromedin U (NMU) are anorexigenic function and metabolic regulation, indicating that NMU is expected to be a potential target for anti-obesity agents. However, in central administration experiments in rats, inconsistent results have been obtained, and the essential role of NMU energy metabolism in rats remain unclear. This study aims to elucidate the role of endogenous NMU in rats. We generated NMU knockout (KO) rats that unexpectedly showed no difference in body weight, adiposity, circulating metabolic markers, body temperature, locomotor activity, and food consumption in both normal and high fat chow feeding. Furthermore, unlike reported in mice, expressions of Nmu and NMU receptor type 2 (Nmur2) mRNA were hardly detectable in the rat hypothalamic nuclei regulating feeding and energy metabolism, including the arcuate nucleus and paraventricular nucleus, while Nmu was expressed in pars tuberalis and Nmur2 was expressed in the ependymal cell layer of the third ventricle. These results indicate that the species-specific expression pattern of Nmu and Nmur2 may allow NMU to have distinct functions across species, and that endogenous NMU does not function as an anorexigenic hormone in rats

Evolutionary histories of breast cancer and related clones

乳がん発生の進化の歴史を解明 --ゲノム解析による発がんメカニズムの探索--. 京都大学プレスリリース. 2023-07-28.Tracking the ol' mutation trail: Unraveling the long history of breast cancer formation. 京都大学プレスリリース. 2023-08-31.Recent studies have documented frequent evolution of clones carrying common cancer mutations in apparently normal tissues, which are implicated in cancer development1, 2, 3. However, our knowledge is still missing with regard to what additional driver events take place in what order, before one or more of these clones in normal tissues ultimately evolve to cancer. Here, using phylogenetic analyses of multiple microdissected samples from both cancer and non-cancer lesions, we show unique evolutionary histories of breast cancers harbouring der(1;16), a common driver alteration found in roughly 20% of breast cancers. The approximate timing of early evolutionary events was estimated from the mutation rate measured in normal epithelial cells. In der(1;16)(+) cancers, the derivative chromosome was acquired from early puberty to late adolescence, followed by the emergence of a common ancestor by the patient’s early 30s, from which both cancer and non-cancer clones evolved. Replacing the pre-existing mammary epithelium in the following years, these clones occupied a large area within the premenopausal breast tissues by the time of cancer diagnosis. Evolution of multiple independent cancer founders from the non-cancer ancestors was common, contributing to intratumour heterogeneity. The number of driver events did not correlate with histology, suggesting the role of local microenvironments and/or epigenetic driver events. A similar evolutionary pattern was also observed in another case evolving from an AKT1-mutated founder. Taken together, our findings provide new insight into how breast cancer evolves

Research Activities in the Department of Nursing

Research activity at the Department of Nursing is overviewed from the point of research topics, the theme of the projects admitted for grant from the Ministry of Education and Science of Japan, and expected research topics, trying to clarify the needs and challenges of the Department from multilateral aspects in future research activities. The Department of Nursing, Aino University is currently divided into the five areas and further into 12 fields. On the other hand, according to the Scientific Research Grant Program (2015 fiscal year), the research topics in nursing science is subdivided into the five areas; a) basic nursing, b) clinical nursing, c) lifelong developmental nursing, d) elderly nursing, and e) community health nursing

Constraint on the gas-to-dust ratio in massive star-forming galaxies at z ∼ 1.4

We carried out [12]CO (J = 2–1) observations toward three star-forming galaxies on the main sequence at z ∼ 1.4 with the Nobeyama 45 m radio telescope. These galaxies have been detected with Spitzer/MIPS in 24 μm, Herschel/SPIRE in 250 μm and 350 μm; their gas metallicity, derived from optical emission line ratios based on near-infrared spectroscopic observations, is close to the solar metallicity. Although weak signal-like features of CO were seen, we could not detect significant CO emission. The dust mass and the upper limits on the molecular gas mass are (3.4–6.7) × 10[8] M⊙ and (9.7–14) × 10[10] (αCO/4.36) M⊙, respectively. The upper limits on the gas-to-dust ratios at z ∼ 1.4 are 150–410, which are comparable to the gas-to-dust ratios in local galaxies with similar gas metallicity. A line stacking analysis enables us to detect significant CO emission and to derive an average molecular gas mass of 1.3 × 10[11] M⊙and gas-to-dust ratio of 250. This gas-to-dust ratio is also near to that in local galaxies with solar metallicity. These results suggest that the gas-to-dust ratio in star-forming galaxies with solar metallicity does not evolve significantly up to z ∼ 1.4. By comparing to a theoretical calculation, a rapid increase of the dust mass in an earlier epoch of galaxy evolution is suggested

鉄道輸送サービスにおける車両運用計画支援システムに関する研究

早大学位記番号:新7997早稲田大

Data from: Spatial variation in bird pollination and its mitigating effects on the genetic diversity of pollen pools accepted by Camellia japonica trees within a population at a landscape level

Bird pollination can vary spatially in response to spatial fluctuations in flowering even within plant populations. In this study, we examined the hypothesis that the spatial variation in bird pollination may induce mitigating effects which maintains or increases genetic diversity of pollen pools at local sites with low flowering densities. To test this hypothesis, we analyzed the landscape-level genetic effects within a population of Camellia japonica on the pollen pools accepted by individuals in two reproductive years by using genotypes at eight microsatellite loci of 1323 seeds from 19 seed parents. Regression analyses using the quadratic models of correlated paternity between pollen pools against spatial distances between the seed-parent pairs revealed not only local pollination but also some amount of long-distance pollen dispersal. The genetic diversity of pollen pools accepted by seed parents tended to be negatively related to the densities of flowering individuals near the seed parents during winter (when the effective pollination of C. japonica is mediated mostly by Zosterops japonica). We show that the low density of flowering individuals may induce the expansion of the foraging areas of Z. japonica and consequently increase the genetic diversity of pollen pools. This spatial variation in bird pollination may induce the mitigating effects on the C. japonica population. The comparisons between the two study years indicate that the overall pattern of bird pollination and the genetic effects described here, including the mitigating effects, may be stable over time