Case-based similar image retrieval for weakly annotated large histopathological images of malignant lymphoma using deep metric learning

In the present study, we propose a novel case-based similar image retrieval (SIR) method for hematoxylin and eosin (H&E)-stained histopathological images of malignant lymphoma. When a whole slide image (WSI) is used as an input query, it is desirable to be able to retrieve similar cases by focusing on image patches in pathologically important regions such as tumor cells. To address this problem, we employ attention-based multiple instance learning, which enables us to focus on tumor-specific regions when the similarity between cases is computed. Moreover, we employ contrastive distance metric learning to incorporate immunohistochemical (IHC) staining patterns as useful supervised information for defining appropriate similarity between heterogeneous malignant lymphoma cases. In the experiment with 249 malignant lymphoma patients, we confirmed that the proposed method exhibited higher evaluation measures than the baseline case-based SIR methods. Furthermore, the subjective evaluation by pathologists revealed that our similarity measure using IHC staining patterns is appropriate for representing the similarity of H&E-stained tissue images for malignant lymphoma

Interactions of fragment ions of tetradecane with solid surfaces

Vapors of tetradecane (C[14]H[30]) were ionized by electron bombardment. The generated fragment ions such as C[3]H[7], C[6]H[13], and C[12]H[25] ions were separated by an E × B filter (Wien filter) and accelerated toward Si(1 0 0) substrates. Thickness measurements showed that thin films were deposited on the Si substrates by C[3]H[7]- and C[6]H[13]-ion irradiation, although the Si substrate surface was predominantly sputtered by C[12]H[25] ions. Rutherford backscattering spectroscopy showed that the irradiation damage by the fragment-ion beams decreased with the increasing molecular weight of the fragment ions at the same acceleration voltage. Furthermore, Raman spectra as well as X-ray photoelectron spectroscopy measurements showed that DLC films were formed by C[3]H[7]- and C[6]H[13]-ion irradiation with the film thickness being larger in case of C[3]H[7]. On the contrary, for C[12]H[25]-ion irradiation, chemical sputtering occurred by surface reactions of hydrogen and methyl radicals with silicon atoms. The chemical reaction at the irradiated substrate surface could be enhanced by the higher temperatures achieved by the high energy–density irradiation effect of the polyatomic ions

Inferior vena cava filter misplacement in the right atrium and migration to the right ventricle followed by successful removal using the endovascular technique: A case report and review of the literature

Inferior vena cava filters are effective for preventing the passage of thrombi into the pulmonary arteries in patients with pulmonary embolism and deep vein thrombosis. These filters are indicated in patients with contraindications to anticoagulant therapy or in patients with recurrent acute pulmonary embolism despite the administration of anticoagulant therapy. However, the occurrence of filter-related complications, such as filter migration to the heart, has been increasing. Herein, we report a case of OptEase inferior vena cava filter misplacement in the right atrium. Although the filter migrated to the right ventricle, it was successfully removed and repositioned in the inferior vena cava using endovascular techniques. Unfortunately, moderate tricuspid regurgitation developed, due to the damage to the tricuspid valve that was caused by the procedure. We have also reviewed the relevant literature and discussed the possible strategies for managing cases of filter migration to the heart and preventing filter misplacement

Nanostructured Si–Ge thermoelectric material for 1200 V/W highly sensitive infrared thermopile sensor device

In this paper, we report the characteristics of a thermopile infrared sensor in which a nanostructured Si–Ge thermoelectric material is used. Although the thermopile infrared sensor is capable of being operated without power consumption, a challenge has been improving its sensitivity. With the aim of improving its sensitivity, we have realized a nanostructured Si–Ge thermoelectric material with low thermal conductivity (0.8 W/m K or less) by forming nanocrystals through heat treatment of amorphous Si–Ge. The thermopile infrared sensor composed of this material exhibited a high sensitivity of 1200 V/W at a pressure of 1.0 × 10−1 Pa or less

Fragility and an extremely low shear modulus of high porosity silicic magma

The rheology and strength of bubbly magma govern eruption dynamics by determining the possibility of fragmentation of ascending magmas. They are also required parameters for understanding seismic monitoring. We measured the rheology and strength of high porosity rhyolitic magma at 500–950 °C. The measured shear modulus and strength are several orders of magnitude lower than bubble-free rhyolite melt, implying that high porosity magma cannot avoid fracturing during magma ascent. The occurrence of fractures is observed in the low-temperature magma (≤800 °C). In this temperature range, the measured attenuation is low. That is, the elastic energy originated by deformations avoids attenuation and is stored in the bubbly magma until released by fracturing (Q > 1). The newly found porosity-dependent strength based on our measurements comprehensively explains three different fragmentation criteria that have been previously proposed independently. Our measurements also show that the shear modulus becomes lower by increasing porosity, which can slow the shear wave velocity. These results suggest that knowing the attenuation of the seismic wave is useful to evaluate magma temperature and the possibility of a fragmentation event that may determine subsequent volcanic activities.This work is supported by JSPS KAKENHI grants 16H04042 and 19H00721

Synthesis of Monodispersed Submillimeter-Sized Molecularly Imprinted Particles Selective for Human Serum Albumin Using Inverse Suspension Polymerization in Water-in-Oil Emulsion Prepared Using Microfluidics

We synthesized monodispersed submillimeter-sized (100 μm–1 mm) microgels by inverse suspension polymerization of water-soluble monomer species with a photoinitiator in water-in-oil (W/O) droplets formed by the microchannel. After fundamental investigations of the selection of suitable surfactants, surfactant concentration, and flow rate, we successfully prepared monodispersed submillimeter-sized W/O droplets. Because radical polymerization based on thermal initiation was not appropriated based on colloidal stability, we selected photoinitiation, which resulted in the successful synthesis of monodispersed submillimeter-sized microgels with sufficient colloidal stability. The microgel size was controlled by the flow rate of the oil phase, which maintained the monodispersity. In addition, the submillimeter-sized microgels exhibit high affinity and selective binding toward HSA utilizing molecular imprinting. We believe the monodispersed submillimeter-sized molecularly imprinted microgels can be used as affinity column packing materials without any biomolecules, such as antibodies, for sample pretreatment to remove unwanted proteins without a pump system