アルドステロン分泌に及ぼす血液pHの影響について

The present investigation was carried out to elucidate whether changes in blood pH induced by administrations of alkalinizing or acidifing agents influence aldosterone secretion. Since aldosterone secretion is known to be regulated by various factors such as the renin-angiotensin system, adrenocorticotropin (ACTH) and serum potassium level, these indices were simultaneously measured during manipulation. Oral administration of NaHCO_3 (alkalinization) of 0.3g・body weight^ resulted in a fall of serum aldosterone with an increase in blood pH, whereas serum cortisol and plasma renin activity remained unchanged. NH_4Cl ingestion (acidification) caused an elevation of aldosterone though the increase was not significant statistically, whereas CaCO_3 ingestion (control) resulted in a significant fall in serum aldosterone. In the experiment of NH_4Cl ingestion, both serum cortisol and plasma renin activity decreased significantly. These results suggest that the fall of aldosterone by alkalinization and the rise of aldosterone by acidification are not induced by either renin angiotensin system or ACTH. On the other hand, serum potassium level fell or rose during alkalinization or acidification. The pattern of the change was similar to the change in proton concentration. From these results, it is concluded that changes in blood pH seem to influence aldosterone secretion independent of renin angiotensin system and ACTH, however, possible involvement of serum potassium concentration on aldosterone secretion can not be denied

Development of an experimental platform for combinative use of an XFEL and a high-power nanosecond laser

We developed an experimental platform for combinative use of an X-ray free electron laser (XFEL) and a high-power nanosecond laser. The main target of the platform is an investigation of matter under high-pressure states produced by a laser-shock compression. In this paper, we show details of the experimental platform, including XFEL parameters and the focusing optics, the laser irradiation system and X-ray diagnostics. As a demonstration of the high-power laser-pump XFEL-probe experiment, we performed an X-ray diffraction measurement. An in-situ single-shot X-ray diffraction pattern expands to a large angle side, which shows a corundum was compressed by laser irradiation.Inubushi, Y.; Yabuuchi, T.; Togashi, T.; Sueda, K.; Miyanishi, K.; Tange, Y.; Ozaki, N.; Matsuoka, T.; Kodama, R.; Osaka, T.; Matsuyama, S.; Yamauchi, K.; Yumoto, H.; Koyama, T.; Ohashi, H.; Tono, K.; Yabashi, M. Development of an Experimental Platform for Combinative Use of an XFEL and a High-Power Nanosecond Laser. Appl. Sci. 2020, 10, 2224. https://doi.org/10.3390/app10072224

HARP : a shared repository project for university libraries in Hiroshima prefecture

DRFIC2008 Poster Session No.21DRFIC2008 ポスターセッション資料 21

HARP : a shared repository project for university libraries in Hiroshima prefecture

DRFIC2008 Poster Session Recap one-minute oral presentation No.21DRFIC2008 ポスターセッションまとめ 口頭プレゼンテーション資料 21

TISSUE FLUID FLOWING INTO GINGIVAL POCKET

The tissue fluid flowing into 129 human gingival pockets of upper anterior teeth in 15 minutes was collected on strips of alter paper. The tissue fluid from each pocket was weighed and the ninhydrin positive substance or free amino acids contained in it was estimated. These results were compared with clinical and histological findings. The weights of tissue fluid and the amounts of ninhydrin positive substance from all clinically healthy gingival pockets were found to be almost the same. There was a correlation between the tissue fluid weight and the amount of the ninhydrin positive substance in every type of periodontal disease. The amount of ninhydrin positive substance tended to increase with the progress of this disease. In many cases the amount of the ninhydrin positive substance increased where inflammatory cell infiltration and degeneration in subepithelial tissue and/ or cell infiltration and roughness in pocket epithelium were recognized. The small amount of free amino acids per mg of tissue fluid was recognized in the case of gingivitis. The amount increased sharply in the case of slight periodontitis, but in the case of severe periodontitis, decreased slightly on the contrary of increase in the total ninhydrin positive substance

A Modified Technique and Hemodynamic Evaluation of Heterotopic Cardiac Transplantation (Modified Ide Method)

A model of heterotopic cardiac transplantation which can evaluate the donor's heart function after preservation was developed. This model was modified from the working double heart model developed by Ide and his associates and is characterized by its ease in suturing in donor and recipient hearts. Five mongrel dogs with the donor heart were observed hemodynamically from 3 to 6 hrs. Systemic circulation was successfully maintained with only the donor heart after ligation of the recipient aorta. This working double heart model consists of total L V bypass and partial RV bypass, and therefore permits estimation of L V function of the donor heart