Characteristics of the studies.

<p>Characteristics of the studies.</p

Annual event rate on each randomized regimen.

<p>Annual event rate on each randomized regimen.</p

Forest plot with OR of prolonged-DAPT relative to short-DAPT for each clinical outcome for the DAPT trial and the pooled population excluding the DAPT trial.

<p>ORs are shown on a logarithmic scale. CI = confidence interval, DAPT = dual anti-platelet therapy, and OR = odds ratio.</p

Definitions of the study endpoint.

<p>Definitions of the study endpoint.</p

Estimated annual event rates for myocardial infarction and stent thrombosis in the short-DAPT group during aspirin mono-therapy.

<p>The landmark data was not available for myocardial infarction in the RESET and EXCELLENT trials. NA = not available.</p

Maximum amplitude of accommodation as a function of the frequency (A) or current (B) of the stimulus.

<p>A: The frequency was varied and the current was fixed at 1 mA. B: The current was varied and the frequency was fixed at 40 Hz. One or 2 drops of phenylephrine hydrochloride was instilled prior to the measurements. The maximum amplitude of accommodation is the average of four eyes of four cats (Cat #2, #4, #6, #7). Error bars indicates standard deviations. Monophasic square pulses at a fixed pulse width of 0.5 ms were applied to the lateral, medial, or both branches of the short ciliary nerve.</p

The time course of the changes in the Zernike coefficients and accommodative changes.

<p>(Cat #1) S. E.: Spherical Equivalent of refractive change, C: Cylindrical value. All data are the values of the change from the initial state. Shaded areas: Stimulation (the pulse train is continuously applied). The current of 1 mA, the frequency of 40 Hz, the duration of pulse train of 8 seconds were applied to the lateral branch of the short ciliary nerve.</p

Pupillary images before and after electrical stimulation of the ciliary nerve (Cat #2 right eye).

<p>A: Before stimulation. B: Maximum dilation when the lateral branch of the short ciliary nerve was stimulated. C: Maximum dilation when medial branch was stimulated. D: Maximum dilation when both side of branch was simultaneously stimulated. Solid line: Detected contour of the pupil. X: The center of the pupil that is represented as the center of gravity that was calculated from contour data.</p

Changes in the velocity of accommodation as a function of maximum accommodation.

<p>Stimulus was applied to the lateral or medial or both branches of the ciliary nerve. The data from all seven cats are plotted. Correlations between the velocity of accommodation and maximum accommodation made by Pearson’s correlation (r = 0.839, <i>P</i><0.001).</p

The average change of Zernike coefficients among the seven cats.

<p>Error bars represent the standard deviations. A current of 1 mA, frequency of 40 Hz, and duration of pulse train of 8 seconds were applied. Comparisons between the two cases (lateral or medial branch of short ciliary nerve stimulation) were made by Student’s <i>t</i> tests. The level of statistical significance was set as P<0.05. (*: P<0.05).</p