Bryosphere within an Antarctic moss pillar

第6回極域科学シンポジウム分野横断セッション：[IB2] 地球環境変動の解析と地球生命システム学の構築11月19日（木）　統計数理研究所 セミナー室1（D305

Potential Application of Raman Spectroscopy for Real-time Diagnosis and Classification of Colorectal Cancer

Raman spectroscopy has become a remarkable tool for real-time detection and diagnosis of various cancers. We investigated whether Raman spectroscopy can be used to diagnose colorectal cancer. Samples of cancerous and non-cancerous tissues were obtained from 12 patients undergoing surgery for such cancer. A handheld Raman spectrometer employing an excitation wavelength of 1,064nm was used at 94 points: 48 points on cancerous tissues and 46 points on normal tissues. Using principal component analysis （PCA）, we selected 12 PCs from the Raman spectra obtained at each of the 94 observed points. We then used linear discriminant analysis （LDA） to distinguish cancer from normal tissues and early cancer from advanced cancer, and we calculated sensitivity, specificity, and accuracy of the Raman spectroscopy for such diagnoses. We immediately confirmed that there was no local temperature rise, color change, or damage at the irradiated points, and we found that Raman spectroscopy was able to distinguish cancer from normal tissues with a sensitivity of 87.5％, specificity of 82.6％, and accuracy of 85.1％. In addition, Raman spectroscopy distinguished early cancer from advanced cancer with a sensitivity of 85.7％, specificity of 83.3％, and accuracy of 85.4％. Thus, near-infrared Raman spectroscopy shows potential as an objective, rapid, non-invasive diagnostic modality for colorectal cancer

Formation of β‐(1,3‐1,6)‐D‐glucan‐complexed [70]fullerene and its photodynamic activity towards macrophages

[70]Fullerene was dissolved in water by the complexation with β‐1,3‐glucan using a mechanochemical high‐speed vibration milling apparatus. The photodynamic activity of β‐1,3 glucan‐complexed C70 was highly dependent on the expression level of dectin‐1 on the cell surfaces of macrophages. The photodynamic activity increased as a result of a synergistic effect between β‐1,3‐glucan‐complexed 1’‐acetoxychavicol acetate and the C70 complex.This work was supported by JSPS KAKENHI Grant‐in‐Aid for Scientific Research (B) (Grant No. JP16H04133), Grant‐in‐Aid for Scientific Research (C) (Grant No. 26350528) and Grant‐in‐Aid for Challenging Exploratory Research (Grant No. JP16K13982)

Unsuspected eukaryotic diversity of aquatic moss pillars inhabiting a freshwater lake in East Antarctica, based on 18S rRNA gene analysis

第2回極域科学シンポジウム/第33回極域生物シンポジウム 11月18日（金） 統計数理研究所 3階リフレッシュフロ

Microfloral association for nitrogen cycling in an Antarctic moss pillar inferred from phylogenetic analyses

第3回極域科学シンポジウム/第34回極域生物シンポジウム 11月27日（火） 国立極地研究所 ３階ラウン