Protein Expression in the Nucleus Accumbens of Rats Exposed to Developmental Vitamin D Deficiency

Introduction: Developmental vitamin D (DVD) deficiency is a candidate risk factor for schizophrenia. Animal models have confirmed that DVD deficiency is associated with a range of altered genomic, proteomic, structural and behavioural outcomes in the rat. Because the nucleus accumbens has been implicated in neuropsychiatric disorders, in the current study we examined protein expression in this region in adult rats exposed to DVD deficienc

Altered proteins in the nucleus accumbens in adult DVD-deficient and control male rats.

<p>Red circles indicate increased spots, blue circles indicate spots reduced in the average gel in DVD animals.</p

Summary of differentially expressed protein spots in nucleus accumbens tissue from adult DVD-deficient and control rats

<p>Summary of differentially expressed protein spots in nucleus accumbens tissue from adult DVD-deficient and control rats</p

Network analysis of the proteins assembled by Ingenuity Pathway Analysis.

<p>Proteins symbols in red were up-regulated, while green were down-regulated. Hub proteins not significantly dysregulated in the study are shown as clear. The proteins with calcium-related functions are annotated (Fx).</p