Multivariate logistic regression analysis.

<p>Multivariate logistic regression analysis.</p

Patients surgical characteristics.

<p>Patients surgical characteristics.</p

Patients demographic characteristics.

<p>Patients demographic characteristics.</p

Complications.

<p>Complications.</p

Long-term results after limited macular translocation surgery for wet age-related macular degeneration

<div><p>Purpose</p><p>To evaluate the long-term results of limited macular translocation (LMT) surgery with radial chorioscleral outfolding in patients with wet age-related macular degeneration (AMD) and subfoveal choroidal neovascularization (CNV). In addition, to identify the factors associated with the final best-corrected visual acuity (BCVA).</p><p>Methods</p><p>The medical records of 20 eyes of 20 consecutive patients (65.2±9.8 years) who had undergone LMT for the treatment of wet AMD and were followed for at least 5 years, were reviewed. The surgical outcomes including the BCVA, degree of foveal displacement, and complications were recorded.</p><p>Results</p><p>The mean foveal displacement was 1332 ± 393 μm after the LMT. The CNV was removed in 16 eyes and photocoagulated in 4 eyes. The mean preoperative VA was 0.83 ± 0.33 logMAR units which significantly improved to 0.59 ± 0.37 logMAR units at 1 year after the surgery (<i>P</i> = 0.015). This BCVA was maintained at 0.59 ± 0.41 logMAR units on the final examination. The final BCVA was significantly correlated with that at 1 year after the surgery (r = 0.83, <i>P</i><0.001). Multiple linear regression analysis showed that the final BCVA was significantly correlated with the BCVA at 1 year after the surgery (<i>P</i><0.001), a recurrence of a CNV (<i>P</i> = 0.001), and the age (<i>P</i> = 0.022).</p><p>Conclusions</p><p>LMT improves the BCVA significantly at 1 year, and the improved BCVA lasted for at least 5 years. These results indicate that the impaired function of the sensory retina at the fovea can recover on the new RPE after the displacement for at least 5 years. The ability to maintain good retinal function on the new RPE for a long period is important for future treatments of CNVs such as the transplantation of RPE cells and stem cells.</p></div

Result of Spearman’s rank correlation coefficient between the choroidal MBR and clinical parameters in patients with severe non-proliferative diabetic retinopathy.

<p>Result of Spearman’s rank correlation coefficient between the choroidal MBR and clinical parameters in patients with severe non-proliferative diabetic retinopathy.</p

Characteristics of the patients with age-related macular degeneration.

<p>Characteristics of the patients with age-related macular degeneration.</p

Intraoperative photographs of limited macular translocation surgery (LMT).

<p>Creating a retinal detachment (white arrowheads) using a 39-gauge injection cannula to infuse balanced salt solution (BSS) (A). White arrows show a choroidal neovascularization (CNV). Clips were placed along a diagonal line beginning 2 mm posterior to the lateral rectus muscle insertion to the superior oblique muscle insertion (B). The new fovea is shown by the white arrowheads. The CNV membrane was grasped with subretinal forceps (white arrows) and removed (C).</p

Mean best-corrected visual acuity (BCVA) ± standard error of the means (± SEM) before and at 1, 2, 3, 4, 5 years and final visit following the LMT surgery.

<p>The BCVA was significantly improved at 1 year after surgery (<i>P</i> = 0.015), and the improved BCVA was maintained for at least 5 years after the surgery. In comparison with the preoperative BCVA, the BCVAs at all of the 3 postoperative time points (Year 1, Year 5, and the final examination) are improved by 2 or more lines of the visual acuity chart in 9 of the 20 eyes (45%), no change in 8 (40%), and decreased in 3 eyes (15%).</p

Results of multiple stepwise regression analysis for independence of factors contributing to ONH MBR.

<p>Results of multiple stepwise regression analysis for independence of factors contributing to ONH MBR.</p