ガン ト エイヨウ フリョウ ガン アクエキシツ ショウカキガン オ チュウシン ニ

A majority of patients with cancer, in particularly cancer of digestive organs, shows malnutrition, leading to worse quality of life and occurrence of several complications. Mechanisms of being malnutrition include anorexia, abnormally affected metabolism, hypercytokinemia, chronic loss of blood, and consumption of nutrition by cancer growing. Nutritional states should be evaluated periodically by somatometry, blood chemistry, subjective nutritional assessment（SGA）, and so on. On the basis of the assessment of nutrition, appropriate supplementation of nutrition should be performed. The routs of nutritional supplementation include oral ingestion, tubural feeding, gastrostomy tube, enterostomy tube, peripheral parenteral nutrition and intravenous hyperalimenation. Thus, appropriate nutritional administration in patients with cancer leads to better outcome of cancer treatment

Naphthalene diimide carrying four ferrocenyl substitutes as an electrochemical indicator of tetraplex DNA aiming at cancer diagnosis

Naphthalene diimide carrying four ferrocenyl substituents, tFND1 and tFND2, were newly synthesized to expect the improved binding affinity for tetraplex DNA and specific electrochemical signal generation. tFND2 shows the 1:2 binding to tetraplex A-core DNA, which has a part of human telomere sequence based on circular dichroism spectra, and the current increase of tFND2 on the tetraplex DNA-immobilized electrode was 13.5-times higher than that on the single stranded DNA-immobilized electrode. When applied to an electrochemical telomerase assay (ECTA) for HeLa cell, tFND2 shows the quantitative change around 0.1–50 cells/μL and the detection limit of 0.1 cells/μL for HeLa cell

Visualization of Bubble and Large Particle Movements in a Fluidized-Bed of Binary Mixture of Particles

Fluidized-bed combustion systems are composed of many kinds of particles with avariety of sizes,e.g.coal,sand,RDF,limestone etc.ln such a binary system of particles，the segregation,if occurs，many harm the combustion，mixing and heat transfer in the bed，depending on the particle movement. The particle movement or circulation in the fluidized-bed depends on many factors，such as the density ratio,size ratio,shape of particle，fluidization velocity. Owing to the difficulty of flow visualization，such particle movement has not been fully understood so far. This paper describes large-particle movement obtained by the flow visualization using neutron radiography. Tracer particles mixed into the fluidized particles indicated clearly bubbles and the cloud behavior around the bubble. Image processing,i.e. PIV and PTV，gives rather clear understanding on the interaction between the large particle，emulsion and/or cloud behavior in the bed

Applicability of radiocolloids, blue dyes and fluorescent indocyanine green to sentinel node biopsy in melanoma

Patients with primary cutaneous melanoma underwent sentinel node (SN) mapping and biopsy at 25 facilities in Japan by the combination of radiocolloid with gamma probe and dye. Technetium-99m (99mTc)-tin colloid, 99mTc-phytate, 2% patent blue violet (PBV) and 0.4% indigo carmine were used as tracers. In some hospitals, 0.5% fluorescent indocyanine green, which allows visualization of the SN with an infrared camera, was concomitantly used and examined. A total of 673 patients were enrolled, and 562 cases were eligible. The detection rates of SN were 95.5% (147/154) with the combination of tin colloid and PBV, 98.9% (368/372) with the combination of phytate and PBV, and 97.2% (35/36) with the combination of tin colloid or phytate and indigo carmine. SN was not detected in 12 cases by the combination method, and the primary tumor was in the head and neck in six of those 12 cases. In eight of 526 cases (1.5%), SN was detected by PBV but not by radiocolloid. There were 13 cases (2.5%) in which SN was detected by radiocolloid but not by PBV. In 18 of 36 cases (50%), SN was detected by radiocolloid but not by indigo carmine. Concomitantly used fluorescent indocyanine green detected SN in all of 67 cases. Interference with transcutaneous oximetry by PVB was observed in some cases, although it caused no clinical trouble. Allergic reactions were not reported with any of the tracers. 99mTc-tin colloid, 99mTc-phytate, PBV and indocyanine green are useful tracers for SN mapping.ArticleJOURNAL OF DERMATOLOGY. 39(4):336-338 (2012)journal articl

Omecamtiv mecarbil in chronic heart failure with reduced ejection fraction, GALACTIC‐HF: baseline characteristics and comparison with contemporary clinical trials

Aims: The safety and efficacy of the novel selective cardiac myosin activator, omecamtiv mecarbil, in patients with heart failure with reduced ejection fraction (HFrEF) is tested in the Global Approach to Lowering Adverse Cardiac outcomes Through Improving Contractility in Heart Failure (GALACTIC‐HF) trial. Here we describe the baseline characteristics of participants in GALACTIC‐HF and how these compare with other contemporary trials. Methods and Results: Adults with established HFrEF, New York Heart Association functional class (NYHA) ≥ II, EF ≤35%, elevated natriuretic peptides and either current hospitalization for HF or history of hospitalization/ emergency department visit for HF within a year were randomized to either placebo or omecamtiv mecarbil (pharmacokinetic‐guided dosing: 25, 37.5 or 50 mg bid). 8256 patients [male (79%), non‐white (22%), mean age 65 years] were enrolled with a mean EF 27%, ischemic etiology in 54%, NYHA II 53% and III/IV 47%, and median NT‐proBNP 1971 pg/mL. HF therapies at baseline were among the most effectively employed in contemporary HF trials. GALACTIC‐HF randomized patients representative of recent HF registries and trials with substantial numbers of patients also having characteristics understudied in previous trials including more from North America (n = 1386), enrolled as inpatients (n = 2084), systolic blood pressure < 100 mmHg (n = 1127), estimated glomerular filtration rate < 30 mL/min/1.73 m2 (n = 528), and treated with sacubitril‐valsartan at baseline (n = 1594). Conclusions: GALACTIC‐HF enrolled a well‐treated, high‐risk population from both inpatient and outpatient settings, which will provide a definitive evaluation of the efficacy and safety of this novel therapy, as well as informing its potential future implementation