How do socio-ecological factors shape culture? Understanding the process of micro-macro interactions

Socio-ecological environments produce certain psychological functions. that are adaptive for survival in each environment. Past evidence suggests that interdependence-related psychological features are prevalent in East Asian cultures partly due to the history of ‘rice-crop farming’ (versus herding) in those areas. However, it is unclear how and why certain functional behaviors required by the socio-ecological environment are sublimated to become cultural values, which are then transmitted and shared among people. In this paper, we conceptually review the works examining various macro sharing processes for cultural values, and focus on the use of multilevel analysis in elucidating the effect of both macro and individual level factors. Uchida et al.’s study (2019) suggests that collective activities at the macro level (community-level), which is required by a certain socio-ecological environment, promote interdependence not only among farmers but also non-farmers. The multilevel processes of how psychological characteristics are construed by macro factors will be discussed

Cross-cultural differences and similarities in proneness to shame: An adaptationist and ecological approach

People vary in how easily they feel ashamed, that is, in their shame proneness. According to the information threat theory of shame, variation in shame proneness should, in part, be regulated by features of a person’s social ecology. On this view, shame is an emotion program that evolved to mitigate the likelihood or costs of reputation-damaging information spreading to others. In social environments where there are fewer possibilities to form new relationships (i.e., low relational mobility), there are higher costs to damaging or losing existing ones. Therefore, shame proneness toward current relationship partners should increase as perceived relational mobility decreases. In contrast, individuals with whom one has little or no relationship history are easy to replace, and so shame-proneness towards them should not be modulated by relational mobility. We tested these predictions cross-culturally by measuring relational mobility and shame proneness towards friends and strangers in Japan, the United States, and the United Kingdom. Japanese subjects were more shame-prone than their British and American counterparts. Critically, lower relational mobility was associated with greater shame proneness towards friends (but not strangers), and this relationship partially mediated the cultural differences in shame proneness. Shame proneness appears tailored to respond to relevant features of one’s social ecology

A Case of Metastatic Hereditary Leiomyomatosis and Renal Cell Cancer Syndrome-Associated Renal Cell Carcinoma Treated with a Sequence of Axitinib and Nivolumab Following Cytoreductive Nephrectomy

Hereditary leiomyomatosis and renal cell cancer syndrome (HLRCC) associated renal cell carcinoma (RCC) is an aggressive form of type 2 papillary RCC caused by deficiency of the fumarate hydratase gene. For patients with metastatic disease, no standard treatment has been established with dismal prognosis. We report a case of metastatic HLRCC-associated RCC in a 65-year-old Japanese male whose clinical features mimicked advanced renal pelvic cancer. A durable response was achieved with a sequence of axitinib and nivolumab after cytoreductive and diagnostic nephrectomy. Their potential therapeutic roles in the management of metastatic HLRCC-associated RCC have been discussed based on its molecular and biological backgrounds

Antecedents and consequences of telework during the COVID-19 pandemic: A natural experiment in Japan

リモートワークの先行要因と結果 --コロナ禍での自然実験による検討--. 京都大学プレスリリース. 2024-03-19.Amidst the global COVID-19 pandemic, telework (remote work) has become a widespread practice adopted by companies worldwide. However, Japan has notably maintained a low rate of telework implementation, suggesting cultural factors hindering its adoption. This study aimed to elucidate the antecedents and consequences of teleworking in Japan. Leveraging the natural experiment created by the COVID-19 pandemic, we addressed two key questions: (1) What socio-psychological factors in Japanese workplaces were important for implementing telework in the first place? and (2) How did the implementation of telework subsequently influence socio-psychological factors in these workplaces? Employees from various Japanese companies completed three waves of an online survey before and during the pandemic. Results showed that telework was more likely to be implemented in organizations characterized by a meritocracy. Results also showed that the implementation of telework demonstrated no measurable negative effects but instead increased levels of independence, organizational commitment, and perceived hierarchy mutability

Development of the Apparatus for High-Speed Decomposition of Sewage Sludge

We investigated the development of the apparatus for high-speed decomposition of sewage sludge. The decomposition mechanism was based on thermophilic oxic process of microorganism. Effect of additional stuff on the stable operation of the apparatus was examined by use of 6 kinds of carrier stuffs. Wood chips as an additional stuff into sewage sludge made the apparatus possible to operate stably and continuously. Decomposition of sewage sludge was carried out efficiency when the weight ratio of sewage sludge to wood chips was less than 10%. The influence of rice bran on the decomposition rate has been studied. The temperature in reaction tank rose with the addition of the rice bran. The decomposition rate of sewage sludge increased with a rise in the temperature. It was clarified that the rice bran was added to the sewage sludge to accelerate the decomposition. It is clear from the measurement of carbon dioxide concentration in exhaust that the decomposition reaction reached in the maximum about 12 hours after the beginning of reaction. The CO, evolution rate increased with a rise in the temperature. Total amount of carbon discharge in the exaust agreeded with the decrease of sewage sludge

Imaging Response to Contemporary Immuno-oncology Combination Therapies in Patients With Metastatic Renal Cell Carcinoma

Combination Therapies; Metastatic Renal Cell CarcinomaTerapias combinadas; Carcinoma metastásico de células renalesTeràpies combinades; Carcinoma metastàtic de cèl·lules renalsImportance The association between treatment with first-line immuno-oncology (IO) combination therapies and physician-assessed objective imaging response among patients with metastatic renal cell carcinoma (mRCC) remains uncharacterized. Objective To compare the likelihood of objective imaging response (ie, complete or partial response) to first-line IO combination ipilimumab-nivolumab (IOIO) therapy vs approved IO with vascular endothelial growth factor inhibitor (IOVE) combination therapies among patients with mRCC. Design, Setting, and Participants This multicenter international cohort study was nested in routine clinical practice. A data set from the International Metastatic Renal Cell Carcinoma Database Consortium (IMDC) was used to identify consecutive patients with mRCC who received treatment with IO combination therapies between May 30, 2013, and September 9, 2021. A total of 899 patients with a histologically confirmed diagnosis of mRCC who received treatment with a first-line IOVE or IOIO regimen and had evaluable responses were included. Exposures Best overall response to first-line IO combination therapy based on Response Evaluation Criteria in Solid Tumors, version 1.1. Main Outcomes and Measures The primary outcome was the difference in treating physician–assessed objective imaging response based on the type of first-line IO combination therapy received. Secondary outcomes included the identification of baseline characteristics positively associated with objective imaging response and the association of objective imaging response with overall survival. Results Among 1085 patients with mRCC who received first-line IO combination therapies, 899 patients (median age, 62.8 years [IQR, 55.9-69.2 years]; 666 male [74.2%]) had evaluable responses. A total of 794 patients had information available on IMDC risk classification; of those, 127 patients (16.0%) had favorable risk, 442 (55.7%) had intermediate risk, and 225 (28.3%) had poor risk. With regard to best overall response among all participants, 37 patients (4.1%) had complete response, 344 (38.3%) had partial response, 315 (35.0%) had stable disease, and 203 (22.6%) had progressive disease. Corresponding median overall survival was not estimable (95% CI, 53.3 months to not estimable) among patients with complete response, 55.9 months (95% CI, 44.1 months to not estimable) among patients with partial response, 48.1 months (95% CI, 33.4 months to not estimable) among patients with stable disease, and 13.0 months (95% CI, 8.4-18.1 months) among patients with progressive disease (log rank P < .001). Treatment with IOVE therapy was found to be independently associated with an increased likelihood of obtaining response (OR, 1.89; 95% CI, 1.26-2.81; P = .002) compared with IOIO therapy. The presence of lung metastases (odds ratio [OR], 1.49; 95% CI, 1.01-2.20), receipt of cytoreductive nephrectomy (OR, 1.59; 95% CI, 1.04-2.43), and favorable IMDC risk (OR, 1.93; 95% CI, 1.10-3.39) were independently associated with an increased likelihood of response. Conclusions and Relevance In this study, treatment with IOVE therapy was associated with significantly increased odds of objective imaging response compared with IOIO therapy. The presence of lung metastases, receipt of cytoreductive nephrectomy, and favorable IMDC risk were associated with increased odds of experiencing objective imaging response. These findings may help inform treatment selection, especially in clinical contexts associated with high-volume multisite metastatic disease, in which obtaining objective imaging response is important

CHAC1 overexpression in human gastric parietal cells with Helicobacter pylori infection in the secretory canaliculi

Background Cation transport regulator 1 (CHAC1), a newly discovered enzyme that degrades glutathione, is induced in Helicobacter pylori (H. pylori)‐infected gastric epithelial cells in culture. The CHAC1‐induced decrease in glutathione leads to an accumulation of reactive oxygen species and somatic mutations in TP53. We evaluated the possible correlation between H. pylori infection and CHAC1 expression in human gastric mucosa. Materials and Methods Both fresh‐frozen and formalin‐fixed paraffin‐embedded tissue samples of gastric mucosa with or without H. pylori infection were obtained from 41 esophageal cancer patients that underwent esophago‐gastrectomy. Fresh samples were used for real‐time polymerase chain reaction for H. pylori DNA and CHAC1 mRNA, and formalin‐fixed samples were used for immunohistochemistry with anti‐CHAC1 and anti‐H. pylori monoclonal antibodies. Double‐enzyme or fluorescence immunohistochemistry and immuno‐electron microscopy were used for further analysis. Results Significant CHAC1 overexpression was detected in H. pylori‐infected parietal cells that expressed the human proton pump/H,K‐ATPase α subunit, whereas a constitutively low level of CHAC1 mRNA expression was observed in the other samples regardless of the H. pylori infection status, reflecting the weak CHAC1 expression detected by immunohistochemistry in the fundic‐gland areas. Immuno‐electron microscopy revealed intact H. pylori cells in the secretory canaliculi of infected parietal cells. Some parietal cells exhibited positive nuclear signals for Ki67 in the neck zone of the gastric fundic‐gland mucosa with H. pylori infection. Conclusion Cation transport regulator 1 overexpression in H. pylori‐infected parietal cells may cause the H. pylori‐induced somatic mutations that contribute to the development of gastric cancer.This work was supported by the Japan Society for the Promotion of Science KAKENHI (16K19077), and by the Practical Research for Innovative Cancer Control from Japan Agency for Medical Research and development, AMED

Nature and Happiness Levels: New SWB Domains for Rivers, a Lake, and Forests

By using a questionnaire survey, we measured nature-related happiness levels, which include specific domains that differ from the overall subjective well-being (SWB) in a Japanese watershed. We regarded nature-related happiness levels, specifically related to rivers, a lake, or forests, as meaningful indices because many people living separated from nature may be unaware of their relationship with nature. We found that nature-related happiness levels had convergent validity and distinct correlation patterns with the explanatory variables, and these patterns were different from those of the overall SWB. These findings support the case of measuring nature-related happiness levels and overall SWB. Nature-related happiness levels were positively correlated with leisure activities and contact with living things. The abundance of rivers in a district is negatively associated with river-related happiness. We speculated that this was due to unidentified disservices associated with the rivers. Lake-related happiness has stronger correlations with relaxation benefits than symbolism, local food culture, art/culture, or water sources. Considering these findings, policymakers should formulate policies based on nature-related happiness levels. Because nature-related happiness levels are not correlated with income level, such policies may contribute to residents’ well-being in an egalitarian manner