Additional file 3: of l-carnitine in critically ill patients—a case series study

Figure S3. Comparison of f-Carnitine transition among the patients with f-Carnitine increased and decreased. The transition of f-Carnitine area for 14 days plotted at each sampling point. The round and square signs within the figure indicate the medians for f-Carnitine, and the error bars indicate 25th and 75th percentile range. The dotted lines indicate the upper and lower reference values for f-Carnitine. The patients whose data are lacking at day 7 or day 14 were excluded from this analysis. (TIFF 123 kb

Additional file 4: of l-carnitine in critically ill patients—a case series study

Figure S4. Correlation of BMI and SOFA score with the change in f-Carnitine from day 0 to day 14. (a) Each plot depicts a relationship between the BMI on the x-axis, and the change of f-Carnitine from day 0 to day 14 (Δ f-Carnitine) on the y-axis. There was a significant negative correlation between the BMI and the Δf-Carnitine (r = − 0.47, p = 0.01), which suggests an association between lower BMI and larger decrease of f-Carnitine. (b) Each plot depicts a relationship between the SOFA score at the time of ICU admission on the x-axis, and the change of f-Carnitine from day 0 to day 14 (Δ f-Carnitine) on the y-axis. There was a significant correlation between the SOFA score on ICU admission and the Δf-Carnitine (r = 0.46, p = 0.01), which suggests an association between high SOFA score and larger decrease of f-Carnitine. (ZIP 188 kb

Additional file 2: of l-carnitine in critically ill patients—a case series study

Figure S2. Distribution of carnitine concentrations on ICU admission. (a) The distribution of t-Carnitine on ICU admission is shown in the histogram. The mean t-Carnitine was 94.9 ± 79.6 nmol/mL, and the median t-Carnitine was 64.2 (50.5–102.3) nmol/mL. (b) The distribution of f-Carnitine on ICU admission is shown in the histogram. The mean f-Carnitine was 68.6 ± 51.2 nmol/mL, and the median f-Carnitine was 50.5 (36.8–80.3) nmol/mL. (ZIP 160 kb

Additional file 5: of l-carnitine in critically ill patients—a case series study

Table S1. Clinical outcomes according to f-carnitine levels at ICU admissiona. (DOCX 21 kb

Additional file 1: of l-carnitine in critically ill patients—a case series study

Figure S1. Flowchart of study enrollment. (TIFF 117 kb