Effects of Dabigatran and Rivaroxaban on TG in PPP (high tissue factor).

<p>TG, thrombin generation triggered by 5 pM recombinant tissue factor; PPP, platelet-poor plasma; Dabi, dabigatran; Riva, rivaroxaban; LT, lag time; TTP, time to peak of TG; PH, peak height of TG; ETP, endogenous thrombin generation potential.</p><p>Data are shown as the mean ± SD. * <i>P</i><0.05, ** <i>P</i><0.01, and *** <i>P</i><0.001 <i>vs.</i> control.</p>§<p>indicates that, since TG curves did not come down to the baseline within 60 min, ETP values were calculated by setting the start tail at 60min.</p

Effects of Dabigatran and Rivaroxaban on Thrombus Formation under Flow Conditions.

<p>The effects of dabigatran and rivaroxaban on thrombus formation in the absence (<b>panels A and B</b>) and presence of aspirin/AR-C66096 (<b>panels C and D</b>) were evaluated using T-TAS. Thrombus formation inside LTP (low thromboplastin) microchips (<b>panels A and C</b>) and HTP (high thromboplastin) microchips (<b>panels B and D</b>). Data (n = 5) are shown as mean values. Shaded boxes indicate the values for T₁₀ and/or OT exceeding 30 min, and the frequency of such measurements is indicated above each box. AUC₃₀, area under the curve for 30 min; OT, occlusion time; T₁₀, time to 10 kPa.</p

Effects of Dabigatran and Rivaroxaban on TG in PRP.

<p>The inhibitory effects of dabigatran (Dabi) and rivaroxaban (Riva) on thrombin generation (TG) in platelet-rich plasma in the absence (<b>panel A</b>) and presence of 100 µM aspirin (Asp) together with 1 µM AR-C66096 (AR-C) (<b>panel B</b>) were calculated using Thrombinoscope™. Typical TG patterns obtained in one of the experiments are shown.</p

Effects of Dabigatran and Rivaroxaban on TG in PPP (low tissue factor).

<p>TG, thrombin generation triggered by 1 pM recombinant tissue factor; PPP, platelet-poor plasma; Dabi, dabigatran; Riva, rivaroxaban; LT, lag time; TTP, time to peak of TG; PH, peak height of TG; ETP, endogenous thrombin generation potential.</p><p>Data are shown as the mean ± SD. * <i>P</i><0.05, ** <i>P</i><0.01, and *** <i>P</i><0.001 <i>vs.</i> control.</p>§<p>indicates that, since TG curves did not come down to the baseline within 60 min, ETP values were calculated by setting the start tail at 60min.</p

Effects of Dabigatran and Rivaroxaban on TG in PPP.

<p>The inhibitory effects of dabigatran (Dabi) and rivaroxaban (Riva) on thrombin generation (TG) in platelet-poor plasma were evaluated using the Thrombinoscope™. <b>Panel A:</b> TG triggered by 1 pM recombinant tissue factor, and <b>Panel B:</b> TG triggered by 5 pM recombinant tissue factor. Typical TG patterns reflecting distinctive efficacies of dabigatran and rivaroxaban are shown.</p