微小甲状腺腫瘍の超音波ガイド下穿刺吸引細胞診の開発と実用化に関する研究

取得学位 : 博士（医学）, 学位授与番号 : 医博乙第1059号, 学位授与年月日：平成1年6月21日,学位授与年：198

I-131 uptake in a thymic cyst

A 61-year-old woman after total thyroidectomy for papillary thyroid cancer underwent I-131 therapy. Focal uptake was seen in the chest on whole body imaging. SPECT/CT delineated I-131 accumulation in an isodense mediastinal lesion which was histologically diagnosed as a thymic cyst. I-131 uptake in a thymic cyst is rare and should be included in the gamut of false-positive entities of I-131 scintigraphy. Copyright © 2010 by Lippincott Williams & Wilkins

Tc-99mDTPAおよびI-131Hippuranによる分腎機能の評価に関する実験的検討 －第二報：一過性腎静脈閉塞について

金沢大学大学院医学系研究

片側性非腫瘤性腎疾患における腎RIアンギオグラフィ

金沢大学大学院医学系研究

Cooperative effect of radioimmunotherapy and antiangiogenic therapy with thalidomide in human cancer xenografts

金沢大学大学院医学系研究科Antiangiogenic therapy may prolong the dormancy of cancer lesions. Moreover, radioimmunotherapy (RIT) may eradicate this population of cells. This study dealt with determining the benefits associated with the combined usefulness of these 2 therapies with respect to inhibition of tumor growth. Methods: Antiangiogenic therapy using oral thalidomide (daily dose, 200 mg/kg) and RIT involving a single intravenous injection (4.63 MBq 131I-A7, an IgG1 murine monoclonal antibody) were conducted in mice bearing LS180 human colon cancer xenografts. RIT with an irrelevant IgG1, HPMS-1, was also performed as a control. Antiangiogenesis of thalidomide was investigated by immunohistochemical analysis of tumor sections. Results: Antiangiogenic therapy and RIT with 131I-A7 significantly suppressed the growth of xenografts. This combination produced more efficient tumor growth inhibition than did the monotherapy (P < 0.005). RIT using 131I-HPMS-1 was far less effective than 131I-A7, even when combined with thalidomide administration. Immunohistochemistry revealed a decrease in the microvessel number within tumors treated with thalidomide (P < 0.0001). Combined therapy further reduced the microvessel number (P < 0.01 vs. thalidomide monotherapy), Conclusion: The combination of RIT and thalidomide antiangiogenic therapy produces a better response of tumors than does monotherapy. Acting in concert, antiangiogenic therapy may prolong the dormancy of cancer lesions and RIT may eradicate this population of cells

Intraperitoneal radioimmunotherapy in treating peritoneal carcinomatosis of colon cancer in mice compared with systemic radioimmunotherapy

医薬保健研究域医学系Peritoneal spread is one of major causes of mortality in colorectal cancer patients. In the current investigation, the efficacy of radio-immunotherapy (RIT) with i.p. administration of an anti-colorectal cancer IgG1, 131 I-A7, was compared to that with i.v. administration in BALB/c female mice bearing peritoneal nodules of LS180 human colon cancer cells, at the same toxicity level. Distribution of either i.p. or i.v. administered 131 I-A7 and i.p. administered irrelevant 131 I-HPMS-1 was assessed. Based on the results of toxicity determination at increments of 2 MBq and estimated dosimetry, an i.p. dose of 11 MBq and an i.v. dose of 9 MBq were chosen for treatment. Mice were monitored for long-term survival: untreated mice (n=11), mice undergoing i.p. RIT with 131 I-A7 (n=11), mice undergoing i.v. RIT with 131 I-A7 (n=11) and mice undergoing non-specific i.p. RIT with 131 I-HPMS-1 (n=5). Intraperitoneal injection of 131 I-A7 produced faster and greater tumor accumulation than i.v. injection: 34.2±16.5% of the injected dose per g (% ID/ g) and 11.1±3.6% ID/g at 2 h, respectively (P<0.0001). Consequently, cumulative radioactivity in tumors was 1.73-fold higher with i.p. injection. 131 I-HPMS-1 did not show specific accumulation. Non-specific RIT with 131 I-HPMS-1 (mean survival, 26.0±2.5 days) did not affect the survival as compared to no treatment (26.7±1.9 days). Intravenous RIT with 131 I-A7 prolonged the survival of mice to 32.8±1.8 days (P<0.01). Intraperitoneal RIT with 131 I-A7 improved the survival more significantly and attained cure in 2 of 11 mice (P<0.05 vs. i.v. RIT). In conclusion, i.p. RIT is more beneficial in treating peritoneal carcinomatosis of colon cancer than i.v. RIT in a murine model

99mTc－MAG3による腎機能評価－123I-OIHおよび99mTc－DTPAとの比較－

金沢大学大学院医学系研究