13 research outputs found
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Improved Upper Limit on Degree-scale CMB B-mode Polarization Power from the 670 Square-degree POLARBEAR Survey
We report an improved measurement of the degree-scale cosmic microwave background B-mode angular-power spectrum over 670 deg2 sky area at 150 GHz with Polarbear. In the original analysis of the data, errors in the angle measurement of the continuously rotating half-wave plate, a polarization modulator, caused significant data loss. By introducing an angle-correction algorithm, the data volume is increased by a factor of 1.8. We report a new analysis using the larger data set. We find the measured B-mode spectrum is consistent with the ΛCDM model with Galactic dust foregrounds. We estimate the contamination of the foreground by cross-correlating our data and Planck 143, 217, and 353 GHz measurements, where its spectrum is modeled as a power law in angular scale and a modified blackbody in frequency. We place an upper limit on the tensor-to-scalar ratio r < 0.33 at 95% confidence level after marginalizing over the foreground parameters
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Evidence for the Cross-correlation between Cosmic Microwave Background Polarization Lensing from Polarbear and Cosmic Shear from Subaru Hyper Suprime-Cam
We present the first measurement of cross-correlation between the lensing potential, reconstructed from cosmic microwave background (CMB) polarization data, and the cosmic shear field from galaxy shapes. This measurement is made using data from the Polarbear CMB experiment and the Subaru Hyper Suprime-Cam (HSC) survey. By analyzing an 11 deg2 overlapping region, we reject the null hypothesis at 3.5σ and constrain the amplitude of the cross-spectrum to , where is the amplitude normalized with respect to the Planck 2018 prediction, based on the flat Λ cold dark matter cosmology. The first measurement of this cross-spectrum without relying on CMB temperature measurements is possible owing to the deep Polarbear map with a noise level of ∼6 μK arcmin, as well as the deep HSC data with a high galaxy number density of . We present a detailed study of the systematics budget to show that residual systematics in our results are negligibly small, which demonstrates the future potential of this cross-correlation technique
Ectopic lymphoid-like structures in infection, cancer and autoimmunity
Ectopic lymphoid-like structures often develop at sites of inflammation where they influence the course of infection, autoimmune disease, cancer and transplant rejection. These lymphoid aggregates range from tight clusters of B cells and T cells to highly organized structures that comprise functional germinal centres. Although the mechanisms governing ectopic lymphoid neogenesis in human pathology remain poorly defined, the presence of ectopic lymphoid-like structures within inflamed tissues has been linked to both protective and deleterious outcomes in patients. In this Review, we discuss investigations in both experimental model systems and patient cohorts to provide a perspective on the formation and functions of ectopic lymphoid-like structures in human pathology, with particular reference to the clinical implications and the potential for therapeutic targeting