Comparison of the characteristics in psoriasis patients with and without CHD.

<p>Comparison of the characteristics in psoriasis patients with and without CHD.</p

Factors related to coronary heart disease (CHD) among the study patients.

<p>Factors related to coronary heart disease (CHD) among the study patients.</p

Reported odds ratios (95% confidence intervals) of risk factors for coronary heart disease.

<p>Reported odds ratios (95% confidence intervals) of risk factors for coronary heart disease.</p

Multivariate logistic regression analysis of the factors related to coronary heart disease.

<p>Data are adjusted for hypertension, dyslipidemia, diabetes mellitus, and psoriasis.</p

Body weight, pulse rate and blood pressure of 11 week-old DS rats.

<p>Values are expressed as the mean ± SEM.</p><p>*<i>P</i> < 0.05 versus LS.</p><p><i>DS rats</i>, Dahl salt-sensitive rats; <i>LS</i>, rats fed a low-salt diet; <i>HS</i>, rats fed a high-salt diet;</p><p>SEM, standard error of the mean.</p><p>Body weight, pulse rate and blood pressure of 11 week-old DS rats.</p

Mitochondrial density and morphology.

<p>(A) Low- and high- power electron micrographs from the left ventricles of rats fed an LS diet and an HS diet. (B) The density of mitochondria (number per 100 μm²) and the size of mitochondria (μm²) were not different between LS and HS group. n = 3 in each group.</p

^99mTc-MIBI signals were decreased in the hearts of DS rats fed a high-salt diet.

<p>(A) A schematic representation of the experiments used to analyze ^99mTc-MIBI and ¹²⁵I-9MPA signals in DS rats. Analyses of ^99mTc-MIBI and ¹²⁵I-9MPA signals in DS rats were performed at 45 min and 6h after injection. (B) At 45 min after injection, the ^99mTc-MIBI signals were lower in DS rats fed an HS diet than those in DS rats fed an LS diet. In the DS rat fed an HS diet and an LS diet, ^99mTc-MIBI signal per heart tissue weight decreased 6 h after the injection compared to 45 min after the injection (left panel) after correction for physical decay. In DS rats fed an HS diet with heart failure at 18 weeks of age, ^99mTc-MIBI signal per heart tissue weight decreased compared to those in control <b> </b>rats fed an LS diet at 6 h after injection. Signals for ^99mTc-MIBI in the liver (middle panel) or blood (right panel) were low in both LS and HS group at 6 h after injection. (LS, 45 min: n = 10, 6 h: n = 10; HS, 45 min: n = 26, 6h: n = 26). LS, low-salt; HS, high-salt. *<i>P</i> < 0.05 versus LS. †<i>P</i> < 0.05 versus the early phase group.</p

Correlation between ^99mTc-MIBI signals and heart weight.

<p>(A) <b> </b>^99mTc-MIBI signal per gram of heart tissue 45 min after the injection was inversely correlated with heart weight (r = -0.88, n = 35, <i>P</i> < 0.0001). (B) ^99mTc-MIBI signal per gram of tissue 6 h after the injection inversely correlated with heart weight (r = -0.81, n = 36, <i>P</i> < 0.0001).</p

Phosphocreatine and ATP were decreased in the hearts CCCP-administered rats.

<p>(A) Representative images of <i>in situ</i> cardiac ³¹P magnetic resonance spectra. ppm, parts per million. (B) The rats administered CCCP showed decreased PCr and βATP (Vehicle: n = 4, CCCP: n = 5). *<i>P</i> < 0.05 versus vehicle-administered rats.</p

Correlation between ^99mTc-MIBI signals and cardiac function.

<p>(A, B) Correlation between fractional shortening on echocardiography and ^99mTc-MIBI signals 45 min after the injection (r = -0.70, n = 36, <i>P</i> = 0.015; A) or 6 h after the injection (r = -0.57, n = 36, <i>P</i> = 0.037; B). (C) Atrial natriuretic factor (<i>ANF)</i> gene expression was significantly increased in DS rats fed an HS diet (HS; n = 52) compared to DS rats fed an LS diet (LS; n = 20). *<i>P</i> < 0.05 versus LS. (D, E) Correlations between ANF gene expression and ^99mTc-MIBI signals 45 min (r = -0.56, n = 36, <i>P</i> = 0.0003; D) and 6 h (r = -0.68, n = 36, <i>P</i> < 0.00001; E) after the injection.</p