Means MBI scores and burnout rates.

<p>a Chi-squared test; the results of three burnout subsets were compared.</p

Baseline characteristics of psychiatrists in the sample group.

<p>a Percentage of the total number of valid values for each variable.</p

Factors associated with burnout and stress: multivariate linear regression analysis (n = 704).

<p>β: standardised regression coefficient.</p><p>VIF: variance inflation factor.</p>a<p>Coded as: 0 =  Male; 1 =  Female.</p>b<p>Coded as: 1 =  Professor or Associate Professor; 2 =  Assistant Professor; 3 =  Psychiatric Resident; 4 =  Postgraduate Student.</p>c<p>Coded as: 0 =  Married; 1 =  Not married.</p>d<p>Coded as: 0 =  Have children; 1 =  Do not have children.</p>e<p>Coded as: 1 =  Less than 40 hours; 2 = 40 to less than 50 hours; 3 = 50 hours or more.</p>f<p>Coded as: 1 =  None; 2 =  Less than 4 times; 3 = 5 to 9 times; 4 = 10 times or more.</p>g<p>Possible range: 1–5. Higher scores indicate higher satisfaction levels.</p>*<p>Statistically significant variables.</p

Rates of work-life balance and environmental satisfaction.

<p>A: Are you experiencing difficulties in maintaining your work-life balance? (1: not at all, 5: very much) B: Are you satisfied with your work environment? (1: not satisfied at all, 5: very much satisfied).</p

Minocycline Modulates Human Social Decision-Making: Possible Impact of Microglia on Personality-Oriented Social Behaviors

<div><h3>Background</h3><p>Microglia, one of the glial cells, play important roles in various brain pathologies including psychiatric disorders. In addition, microglia have recently been proved to monitor synaptic reactions via direct-touching even in normal brain. Human microglia may modulate various social/mental functions, while microglial social/mental roles remain unresolved especially in healthy humans. There is no known drug with the specific effect of modulating microglia. Therefore, using minocycline, a tetracycline antibiotic and the most famous microglial inhibitor, is one of the best alternative approaches to clarify microglial functions on human social/mental activities.</p> <h3>Methodology/Principal Findings</h3><p>We conducted a double-blind randomized trial of trust game, a monetary decision-making experiment, with ninety-nine human adult males who decided how much to trust an anonymous partner after a four-day administration of minocycline. Our previous pilot trial indicated a positive effect of minocycline, while the underlying mechanisms were not clarified. Therefore, in this trial with larger samples, we additionally measured the effects of anxiety and personality. The monetary score in trust game was significantly lower in the minocycline group. Interestingly, participants’ ways of decision-making were significantly shifted; cooperativeness, one component of personality, proved to be the main modulating factor of decision-making in the placebo group, on the other hand, the minocycline group was mainly modulated by state anxiety and trustworthiness.</p> <h3>Conclusions/Significance</h3><p>Our results suggest that minocycline led to more situation-oriented decision-making, possibly by suppressing the effects of personality traits, and furthermore that personality and social behaviors might be modulated by microglia. Early-life events may activate human microglia, establish a certain neuro-synaptic connection, and this formation may determine each human’s personality and personality- oriented social behaviors in later life. To explore these mechanisms, further translational research is needed.</p> <h3>Trial Registration</h3><p>UMIN clinical trial center <a href="http://tinyurl.com/7yvmpxb">UMIN000004803</a></p> </div

Association between work-life balance satisfaction and burnout.

<p>Are you experiencing difficulties in maintaining your work-life balance? (1: not at all, 5: very much).</p

Trust Game Structure.

<p>Trust Game Structure.</p

Multiple Regression Analysis on Behavior in Trust Game.

<p>Note: *p<.05,</p>**<p>p<.01.</p><p>We performed a multiple linear regression analysis of the amount of money offered in trust game as the dependent variable, and subscales of TCI, STAI and GTS as independent variables by conditions. Remarkable effects are shown in the Table.</p

Behavior in Trust Game, and Effects of Minocycline on Personality, Anxiety and Trust.

<p>We performed t-test on the behavior (monetary score) in trust game, and the average scores are shown in the Table. The effects of minocycline on personality, anxiety and trust were evaluated with the seven subscales of TCI, the two subscales of STAI, and GTS. We performed ANOVA with a repeated measure; the scores of the subscales as the dependent variable, and drug condition (Minocycline vs. Control), repeated measure of the subscales’ scores (<i>Before</i> vs. <i>After</i> treatment) and their interaction as independent variables. As four participants (three for control, one for minocycline group) failed to complete the questions of STAI and GTS, 95 sets of data were analyzed. Significant and/or marginal effects are shown in the Table. Results were expressed as means (S.D.).</p

The ratio of monetary score given by partner’s sex and attractiveness (** p<.01).

<p>The ratio of monetary score given by partner’s sex and attractiveness (** p<.01).</p