Fosfluconazole for Antifungal Prophylaxis in Very Low Birth Weight Infants

We conducted a retrospective case series study to evaluate the safety of fosfluconazole prophylaxis for preventing invasive fungal infection in VLBW infants with a central vascular access. Fosfluconazole was administered intravenously at a dose of 6 mg/kg everyday during which time a central venous catheter was placed. A total of 23 infants met the criteria for enrollment in our study. No cases of fungal infection were detected during the central venous catheter placement in the group. None of the infants had an elevated β-D-glucan, and all of them were still alive at discharge. Regarding the liver and renal function, no statistically significant differences were observed before and at the end of fosfluconazole prophylaxis. The results of this study demonstrate that fosfluconazole prophylaxis in preventing invasive fungal infection was well tolerated by VLBW infants. This is a first report to describe antifungal prophylaxis using fosfluconazole for VLBW infants

Clinical significance of ribosomal protein S15 expression in patients with colorectal cancer liver metastases

Sakano Y., Matoba D., Noda T., et al. Clinical significance of ribosomal protein S15 expression in patients with colorectal cancer liver metastases. Journal of Hepato-Biliary-Pancreatic Sciences, (2024); https://doi.org/10.1002/jhbp.12012.Background: Liver metastasis is the most frequently observed distant metastasis of colorectal cancer, and the residual liver recurrence rate after hepatic resection is still high. To explore the mechanism of liver metastasis to discover potential new treatments, we assessed the relationship between the expression of differentially expressed genes (DEGs) and prognosis in patients with colorectal cancer liver metastasis (CRLM). Methods: The gene expression dataset was extracted from The Cancer Genome Atlas and the Gene Expression Omnibus. Significance analysis of DEGs between tumor and normal samples of colorectum, liver, and lung was conducted. A total of 80 CRLM patients were studied to assess the expression of RPS15, characteristics, and outcomes. We examined the relationships of RPS15 expression to cell viability and apoptosis in vitro and vivo. Results: Significance analysis identified 33 DEGs. In our cohorts, the overall survival rates were significantly lower in the high-RPS15-expression group, and high expression of RPS15 was an independent and unfavorable prognostic factor in recurrence-free survival and overall survival. Knockdown of RPS15 expression reduced the proliferative capacity of colorectal cancer cells and increased BAX-induced apoptotic cell death. Conclusions: RPS15 expression is an independent prognostic factor for CRLM patients and might be a novel therapeutic target for CRLM

Oxidative Neurodegeneration Is Prevented by UCP0045037, an Allosteric Modulator for the Reduced Form of DJ-1, a Wild-Type of Familial Parkinson’s Disease-Linked PARK7

Although a loss-of-function mutation has been identified in familial Parkinson’s disease PARK7, the wild-type of DJ-1 is known to act as an oxidative stress sensor in neuronal cells. Recently, we identified UCP0045037 as a compound that bound to the reduced form of DJ-1 by in silico virtual screening. In this study, we determined the neuroprotective effects of UCP0045037 against focal cerebral ischemia-induced neurodegeneration in rats. Hydrogen peroxide-induced cell death was significantly inhibited by UCP0045037 in both rat mesencephalic dopaminergic neurons and human normal SH-SY5Y cells. In contrast, DJ-1-knockdown SH-SY5Y cells lost the protective activity of UCP0045037. These results suggest that UCP0045037 interacts with endogenous DJ-1 and produces a neuroprotective response

Kansai University Library 100th anniversary

目次 【序文】記念誌の刊行にあたって（図書館長　内田慶市）図書館創設100周年によせて（学長　楠見晴重）記念誌の編集について【第1部　この20年を振り返って】高槻図書室開館（広瀬雅子）…3阪神・淡路大震災（高橋真澄）…8図書館システムの変遷（徳岡久実・濱生快彦）…12図書館ビジョン7項目の制定（濱生快彦）…20図書館におけるアウトソーシング（高橋真澄）…26電子展示（濱生快彦）…36市民利用開始（広瀬雅子）…41図書館ウェブサイト（濱生快彦）…442010プロジェクトによる新図書館（高橋真澄・田中恵美）…48図書館リニューアル工事（新谷大二郎）…60図書館の現在と未来（堀口和弘）…68【第2部　図書館に想う】関西大学図書館創設100周年に寄せて（市川訓敏）…79図書館の思い出、図書館への思い（北川勝彦）…85図書館在職時の思い出（柴田真一）…91数々の貴重書（田中登）…95関西大学図書館100周年にあたって : 私の夢想する図書館（内田慶市）…100【第3部　図書館の文庫・コレクション】文庫・コレクションの紹介（鵜飼香織）…111【第4部　資料編】図書館年譜（明治19.3 ～平成26.7）…119サービスに係る統計（総合図書館）…146サービスに係る統計（高槻図書室・ミューズ大学図書館・堺キャンパス図書館）…148蔵書数の推移…149図書費執行額の推移…150展示一覧…152他大学図書館との協定一覧…160【「図書館コラム」】新人時代の思い出（高松和美）…11エレベーターにまつわる話（吉田有輝）…19泣き別れたり、親子になったり（嶋田有理香）…35貴重なのは本だけ？貴重書担当のつぶやき（大上良樹）…40会長校のころ（金東瀅）…46『コアラ博士』にまつわるあれこれ（松本和剛）…57広報誌『KULione 』誕生秘話（白髪友賀）…59本と夢を運んだテレリフト（芝谷秀司）…66LOUIS VUITTON（加藤博之）…7

Feasibility of neurally adjusted positive end-expiratory pressure in rabbits with early experimental lung injury

Abstract Background During conventional Neurally Adjusted Ventilatory Assist (NAVA), the electrical activity of the diaphragm (EAdi) is used for triggering and cycling-off inspiratory assist, with a fixed PEEP (so called “Triggered Neurally Adjusted Ventilatory Assist” or “tNAVA”). However, significant post-inspiratory activity of the diaphragm can occur, believed to play a role in maintaining end-expiratory lung volume. Adjusting pressure continuously, in proportion to both inspiratory and expiratory EAdi (Continuous NAVA, or cNAVA), would not only offer inspiratory assist for tidal breathing, but also may aid in delivering a “neurally adjusted PEEP”, and more specific breath-by-breath unloading. Methods Nine adult New Zealand white rabbits were ventilated during independent conditions of: resistive loading (RES1 or RES2), CO2 load (CO2) and acute lung injury (ALI), either via tracheotomy (INV) or non-invasively (NIV). There were a total of six conditions, applied in a non-randomized fashion: INV-RES1, INV-CO2, NIV-CO2, NIV-RES2, NIV-ALI, INV-ALI. For each condition, tNAVA was applied first (3 min), followed by 3 min of cNAVA. This comparison was repeated 3 times (repeated cross-over design). The NAVA level was always the same for both modes, but was newly titrated for each condition. PEEP was manually set to zero during tNAVA. During cNAVA, the assist during expiration was proportional to the EAdi. During all runs and conditions, ventilator-delivered pressure (Pvent), esophageal pressure (Pes), and diaphragm electrical activity (EAdi) were measured continuously. The tracings were analyzed breath-by-breath to obtain peak inspiratory and mean expiratory values. Results For the same peak Pvent, the distribution of inspiratory and expiratory pressure differed between tNAVA and cNAVA. For each condition, the mean expiratory Pvent was always higher (for all conditions 4.0 ± 1.1 vs. 1.1 ± 0.5 cmH2O, P < 0.01) in cNAVA than in tNAVA. Relative to tNAVA, mean inspiratory EAdi was reduced on average (for all conditions) by 19 % (range 14 %–25 %), p < 0.05. Mean expiratory EAdi was also lower during cNAVA (during INV-RES1, INV-CO2, INV-ALI, NIV-CO2 and NIV-ALI respectively, P < 0.05). The inspiratory Pes was reduced during cNAVA all 6 conditions (p < 0.05). Unlike tNAVA, during cNAVA the expiratory pressure was comparable with that predicted mathematically (mean difference of 0.2 ± 0.8 cmH2O). Conclusion Continuous NAVA was able to apply neurally adjusted PEEP, which led to a reduction in inspiratory effort compared to triggered NAVA