Magnetic Ground State of Pr0.89_{0.89}LaCe0.11_{0.11}CuO4+α−δ_{4+\alpha-\delta} with Varied Oxygen Depletion Probed by Muon Spin Relaxation

The magnetic ground state of an electron-doped cuprate superconductor Pr$_{1-x}$LaCe$_x$CuO$_{4+\alpha-\delta}$ ($x=0.11, \alpha\simeq0.04$) has been studied by means of muon spin rotation/relaxation (\msr) over a wide variety of oxygen depletion, $0.03\le\delta\le0.12$. Appearance of weak random magnetism over entire crystal volume has been revealed by a slow exponential relaxation. The absence of $\delta$-dependence for the random magnetism and the multiplet pattern of muon Knight shift at higher fields strongly suggest that the random moments are associated with excited Pr$^{3+}$ ions under crystal electric field.Comment: 6 pages, 4 figures, submitted to J. Phys. Soc. Jp

Resminostat in EGFR-mutated lung cancer

Drug-tolerant cells are mediators of acquired resistance. BIM-intron2 deletion polymorphism (BIM-del) is one of the mechanisms underlying the resistance to epidermal growth factor tyrosine kinase inhibitor (EGFR-TKI)-mediated apoptosis that induces drug tolerance. Here, we investigated whether resminostat, a histone deacetylase inhibitor, circumvents BIM-del-associated apoptosis resistance. The human EGFR-mutated non-small cell lung cancer (NSCLC) cell line PC-9 and its homozygous BIM-del-positive variant (PC-9 BIMi2-/-), established by editing with zinc finger nuclease, were used. In comparison with PC-9 cells, PC-9 BIMi2-/- cells were less sensitive to apoptosis mediated by EGFR-TKIs such as gefitinib and osimertinib. The combined use of resminostat and an EGFR-TKI preferentially induced the expression of the pro-apoptotic BIM transcript containing exon 4 rather than that containing exon 3, increased the level of pro-apoptotic BIM protein (BIMEL), and stimulated apoptosis in vitro. In a subcutaneous tumor model derived from PC-9 BIMi2-/- cells, gefitinib monotherapy decreased tumor size but retained residual lesions, indicative of the presence of tolerant cells in tumors. The combined use of resminostat and gefitinib increased BIMEL protein level and induced apoptosis, subsequently leading to the remarkable shrinkage of tumor. These findings suggest the potential of resminostat to circumvent tolerance to EGFR-TKIs associated with BIM deletion polymorphism

分枝5，6‐ヘキソーセン類の還元反応における立体選択性

講演番号：1 E1 1

Nonlocal Effects and Shrinkage of the Vortex Core Radius in YNi2B2C Probed by muSR

The magnetic field distribution in the vortex state of YNi2B2C has been probed by muon spin rotation (muSR). The analysis based on the London model with nonlocal corrections shows that the vortex lattice has changed from hexagonal to square with increasing magnetic field H. At low fields the vortex core radius, rho_v(H), decreases with increasing H much steeper than what is expected from the sqrt(H) behavior of the Sommerfeld constant gamma(H), strongly suggesting that the anomaly in gamma(H) primarily arises from the quasiparticle excitations outside the vortex cores.Comment: 4 pages, 4 figures, submitted to Phys. Rev.

分枝5,6-へキソーセン類のFerrier反応による分枝サイクリトール合成の立体化学

講演番号：3 IL 3

Recent Results from LHD Experiment with Emphasis on Relation to Theory from Experimentalist’s View

he Large Helical Device (LHD) has been extending an operational regime of net-current free plasmas towardsthe fusion relevant condition with taking advantage of a net current-free heliotron concept and employing a superconducting coil system. Heating capability has exceeded 10 MW and the central ion and electron temperatureshave reached 7 and 10 keV, respectively. The maximum value of β and pulse length have been extended to 3.2% and 150 s, respectively. Many encouraging physical findings have been obtained. Topics from recent experiments, which should be emphasized from the aspect of theoretical approaches, are reviewed. Those are (1) Prominent features in the inward shifted configuration, i.e., mitigation of an ideal interchange mode in the configuration with magnetic hill, and confinement improvement due to suppression of both anomalous and neoclassical transport, (2) Demonstration ofbifurcation of radial electric field and associated formation of an internal transport barrier, and (3) Dynamics of magnetic islands and clarification of the role of separatrix

Possibility of Breast Cancer Prevention: Use of Soy Isoflavones and Fermented Soy Beverage Produced Using Probiotics

The various beneficial effects of soybeans, which are rich in phytochemicals, have received much attention because of increasing health awareness. Soy milk that has been fermented using lactic acid bacteria has been used to prepare cheese-like products, tofu (bean-curd), and yogurt-type products. However, the distinct odor of soybeans has limited the acceptance of such foods, particularly in Western countries. In Japan, while tofu and soy milk have long been habitually consumed, the development of novel, palatable food products has not been easy. The unpleasant odor of soy milk and the absorption efficiency for isoflavones can be improved using a recently developed fermented soy milk beverage. Cancer has been the leading cause of death, and breast cancer is the most common malignancy among women. The most common type of breast cancer is estrogen-dependent, and the anti-estrogenic effects of isoflavones are known. The present review focuses on the characteristics of soy milk fermented using probiotics, an epidemiological study examining the incidence of breast cancer and soy isoflavone consumption, and a non-clinical study examining breast cancer prevention using fermented soy milk beverage

大都市近郊の公有地化された農地の維持システムに関する研究 : 東京大都市圏近郊の見沼田圃の事例

Due to rapid urbanization, farmland is declining in suburban areas. The environment of agriculture in suburban area is severe as reflected in changes in rural societies, encroachment of farmland and invasion by urban land use such as residential place, commercial areas, increasing land prices and the problem of inheritance tax. In order to deal with such circumstances, preservation of farmland is essential, and various policies and activities regarding preservation of farmland are implemented. Public ownership of farmland is one of these methods. Its purpose is that public organizations acquire the private farmland which cannot be managed by its legal owners, and manage it in such a way that its productive potential is preserved. The importance of this method is increasing in suburban areas. Public farmland is managed by its continuous use as farmland, but the sustainable management system of public farmland in suburban areas is not clear enough. Sustainable management system is defined as continuous utilization of public farmland by people. Therefore, this research aims to clarify the working of the sustainable system of public farmland in suburban areas. This research is based on the systems theory for management of agriculture of Bryant and Johnston (1992) , which looks at the elements of planning, land, labor, capital and management, as the key elements of the system. In order to apply it to public farmland, however, capital and management (which are conducted by the administrative body and as a consequence remain stable) can be ignored and only planning, land and labor variables are considered. Taking into consideration the characteristics of public farmland, the following relationships and activities are considered in place of planning, land and labor respectively: the relationship between the managing entity, which is a general term for the land owner entity, the management entity and the user entity, and the type of activity (planning), the relationship between the public farmland and the function of farmland exerted by the type of activity (land), and the leisure and educational activities (labor). In addition, based on the private interest and the public interest in the main functions of farmland in urban fringes conceptualized by Bryant and Johnston, the 4 functions of production, protection, play and education are considered in the case of public farmland, and the framework of this research is formulated. Minum a rice fields in Saitama prefecture is focus of the present research. Minuma rice fields suffered severe damage by typhoon No.12 (Kanogawa typhoon) in 1958. All the areas of Minuma rice fields were flooded and most part of the urban area of Kawaguchi city, which is downstream from Minuma rice fields, was inundated. The water storage function of Minuma rice fields was reconsidered inspired by the Kanogawa typhoon, and "Minuma 3 principles," which does not allow using the farmland in Minuma rice fields for other purposes such as residential areas and industrial areas, was set in 1965; afterwards, the public land promotion policy was decided in the "Basic policy for sustainable management, use and preservation of Minuma rice fields" in 1995. After that, Saitama prefecture commissioned Saitama Agriculture & Forestry Corporation and civic groups to manage the public farmland acquired for Minuma rice fields public land promotion policy. Therefore, Saitama Agriculture & Forestry Corporation and civic groups are used as examples for this research. Saitama Agriculture & Forestry Corporation has implemented works for maintenance and management including mowing as preparation for tillage based on the discussion with the land owner, Saitama prefecture since they were commissioned management in 1998. First, the activities were conducted only by Saitama prefecture and Saitama Agriculture & Forestry Corporation, and they started from mowing, and cultivation of landscape amenity crops was added in 1999 in order to improve the landscape. Later on, activities such as hands-on farming experiences, communion (Fureai) farm for residents of the prefecture, agricultural prep school and School children\u27s farm, which is part of the hands-on farming activities were added one by one, and those activities accepted citizens, neighboring, residents, corporations and educational institutions to participate as user entities. In spite of the fact that the number of activities increased, the system that only one activity is allocated to one plot of public farmland has not changed, but multiple functions of farmland are exerted by one activity, and the farmland is therefore smoothly managed. Civic groups conduct activities in different ways. They decide the land management policy with Saitama prefecture, but the actual content of activities is decided by the civic groups. They have implemented multiple activities since they started maintenance and management of the public farmland, and multiple user entities including Kawaguchi city, civic groups other than the management entity, citizens, neighboring residents and corporations and sustaining entity have participated in them. In addition, multiple activities are allocated to one plot of public farmland, and as a consequence, various functions of farmland are exerted. As they continued organizing activities, the number of types of activities increased, and educational institutions were added to the original list of user entities, civic groups, citizens, neighboring residents and corporations. According to our survey, when the management entity implements multiple activities on one plot of public farmland, that means that multiple functions of farmland are exerted, and the farmland is thus smoothly maintained. The two case studies of an agriculture and forestry public corporation and a local civic group, revealed the fact that the sustainable management system of public farmland in a suburban area is a system which maintains the farmland by a combination of the following processes: (1) increase of land managing entities, (2) diversification of activities, (3) increase in the units of activity in farmland, and (4) increase in the range of functions of farmland. Although previous research on the sustainable management system of farmland concluded that the sustainable management system of private farmland is influenced only by the increase in the range of functions of farmland, the sustainable system could not be discussed only by increase in the range of functions of farmland in case of public farmland. The originality of this research is that it reveals the fact that the sustainable management system of public farmland involves a combination of processes (1)(2)(3)(4), and the flow of those processes are (1)→ (2)→(4) or (1)→(2)→(3)→(4), while the processes (1) and (2) lead to the process (4). Whether (3) is exited or not is not mandatory to the presence of the sustainable management system. Therefore, for the sustainable management system of public farmland, it is important to promote (1) and (2) and to promote activities concerning leisure of people and educational activities, because there are more activities related to them.首都大学東京, 2013-03-25, 博士 (観光科学), 甲第366号首都大学東