Impacts of a warming marginal sea on torrential rainfall organized under the Asian summer monsoon

Monsoonal airflow from the tropics triggers torrential rainfall over coastal regions of East Asia in summer, bringing flooding situations into areas of growing population and industries. However, impacts of rapid seasonal warming of the shallow East China Sea ECS and its pronounced future warming upon extreme summertime rainfall have not been explored. Here we show through cloudresolving atmospheric model simulations that observational tendency for torrential rainfall events over western Japan to occur most frequently in July cannot be reproduced without the rapid seasonal warming of ECS. The simulations also suggest that the future ECS warming will increase precipitation substantially in such an extreme event as observed in midJuly 2012 and also the likelihood of such an event occurring in June. A need is thus urged for reducing uncertainties in future temperature projections over ECS and other marginal seas for better projections of extreme summertime rainfall in the surrounding areas

Phosphorylated Smad2 in Advanced Stage Gastric Carcinoma

<p>Abstract</p> <p>Background</p> <p>Transforming growth factor β (TGFβ) receptor signaling is closely associated with the invasion ability of gastric cancer cells. Although Smad signal is a critical integrator of TGFβ receptor signaling transduction systems, not much is known about the role of Smad2 expression in gastric carcinoma. The aim of the current study is to clarify the role of phosphorylated Smad2 (p-Smad2) in gastric adenocarcinomas at advanced stages.</p> <p>Methods</p> <p>Immunohistochemical staining with anti-p-Smad2 was performed on paraffin-embedded specimens from 135 patients with advanced gastric adenocarcinomas. We also evaluated the relationship between the expression levels of p-Smad2 and clinicopathologic characteristics of patients with gastric adenocarcinomas.</p> <p>Results</p> <p>The p-Smad2 expression level was high in 63 (47%) of 135 gastric carcinomas. The p-Smad2 expression level was significantly higher in diffuse type carcinoma (p = 0.007), tumours with peritoneal metastasis (p = 0.017), and tumours with lymph node metastasis (p = 0.047). The prognosis for p-Smad2-high patients was significantly (p = 0.035, log-rank) poorer than that of p-Smad2-low patients, while a multivariate analysis revealed that p-Smad2 expression was not an independence prognostic factor.</p> <p>Conclusion</p> <p>The expression of p-Smad2 is associated with malignant phenotype and poor prognosis in patients with advanced gastric carcinoma.</p

Different Efflux Transporter Affinity and Metabolism of 99m Tc-2-Methoxyisobutylisonitrile and 99m Tc-Tetrofosmin for Multidrug Resistance Monitoring in Cancer.

Little is known about the affinity and stability of Tc-labeled 2-methoxyisobutylisonitrile (Tc-MIBI) and tetrofosmin (Tc-TF) for imaging of multiple drug resistance transporters in cancer. We examined the affinity of Tc-labeled compounds for these transporters and their stability