Studies on Monitoring Tumor Response in Head and Neck to Radiation Therapy by Using P-31 MR Spectroscopy

We studied the usefulness of P-31 MRS (magnetic resonance spectroscopy) for the early indication and monitoring of responses to radiation therapy in 30 patients with superficial tumors in the head and neck regions. P-31 MRS was used to estimate phosphomonoesters (PME) in tumors before and after patients were subjected to 20 Gy radiation therapy. Computed tomography ( CT) was carried out to measure tumor sizes before and after patients received 40~45 Gy of radiation. The relationship between the changes in PME levels and the reduction in tumor size was investigated. In the tumors of 30 patients, the concentration ratio of PME / β -adenosine triphosphate (ATP) was 0.99 ± 0.53 (mean±SD) before radiation treatment. The MR spectra of 23 tumors after 20 Gy radiation were detectable, but those of 7 tumors were not. We found a significant positive correlation between the PME/ β-ATP reduction ratio and the tumor reduction ratio for the 23 tumors with detectable spectra after being subjected to 20 Gy radiation. The response rate was 85.7% after 40~45 Gy radiation for the 7 tumors with spectra below the noise level after 20 Gy radiation. The present results suggest that PME/β-ATP is a useful parameter for estimation of the early response of tumors to radiotherapy.departmental bulletin pape

Deployment of Safety Education for Children through Community Cooperation : Based on Case Study involving Afterschool Watch Activities and Drafting of Community Safety Map

departmental bulletin pape

Development of the original products designed by Tokoha university using local specialties

departmental bulletin pape

Product development project using local "sub-standard agricultural products", with an awareness of food loss

departmental bulletin pape

P-31-Magnetic Resonance Spectroscopy Studies in Patients with Temporal Lobe Epilepsy

To assess whether the P-31-MRS method is useful in determining the lateralization of the epileptic focus, 30 patients with temporal lobe epilepsy and 8 controls were examined using the depth-resolved surface coil spectroscopy (DRESS) method. The PME/ β-ATP ratio increased and the PCr/Pi ratio decreased in the mesial temporal region with epileptic focus, in comparison with the contralateral region. In the controls, no significant differences were found between the left and right mesial temporal regions. An increased PME/ β-ATP in the epileptic focus was found in 10 out of the 11 patients with well defined focus. These results would indicate the clinical usefulness of the P-31-MRS method in lateralizing the epileptic focus in patients with temporal lobe epilepsy

Studies on Monitoring Tumor Response in Head and Neck to Radiation Therapy by Using P-31 MR Spectroscopy

We studied the usefulness of P-31 MRS (magnetic resonance spectroscopy) for the early indication and monitoring of responses to radiation therapy in 30 patients with superficial tumors in the head and neck regions. P-31 MRS was used to estimate phosphomonoesters (PME) in tumors before and after patients were subjected to 20 Gy radiation therapy. Computed tomography ( CT) was carried out to measure tumor sizes before and after patients received 40~45 Gy of radiation. The relationship between the changes in PME levels and the reduction in tumor size was investigated. In the tumors of 30 patients, the concentration ratio of PME / β -adenosine triphosphate (ATP) was 0.99 ± 0.53 (mean±SD) before radiation treatment. The MR spectra of 23 tumors after 20 Gy radiation were detectable, but those of 7 tumors were not. We found a significant positive correlation between the PME/ β-ATP reduction ratio and the tumor reduction ratio for the 23 tumors with detectable spectra after being subjected to 20 Gy radiation. The response rate was 85.7% after 40~45 Gy radiation for the 7 tumors with spectra below the noise level after 20 Gy radiation. The present results suggest that PME/β-ATP is a useful parameter for estimation of the early response of tumors to radiotherapy