6,396 research outputs found
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Assessment of Canine Pancreas-Specific Lipase and Outcomes in Dogs with Hemodialysis-Dependent Acute Kidney Injury.
BackgroundRenal replacement therapies can be life-saving for dogs with severe acute kidney injury (AKI), however, comorbidities including pancreatitis might affect outcome.Hypothesis/objectivesTo investigate the prevalence of pancreas-specific lipase (Spec cPL) measurements consistent with pancreatitis (≥400 μg/L) in dogs undergoing intermittent hemodialysis (IHD) for treatment of AKI and to determine whether there were associations between 30-days outcomes and Spec cPL measurements.AnimalsFifty-three client-owned dogs presented to teaching hospitals between November 2008 and September 2016 that underwent IHD.MethodsRetrospective medical record review from dogs that received IHD for management of AKI and also had a Spec cPL measurement. Association between survival, dialysis-dependency, and Spec cPL measurements was assessed.ResultsForty of 53 (76%) dogs were alive at 30-days and 33/53(62%) had a Spec cPL result ≥400 μg/L. Spec cPL was not significantly different either between surviving (635.5 μg/L, range 29-1,001) and nonsurviving dogs (860 μg/L, range 56-1,001; P = 0.75) or between dialysis-dependent (1,001 μg/L, range 177-1,001) and nondialysis-dependent dogs (520 μg/L, range 29-1,001; P = 0.08). Spec cPL ≥400 μg/L was not significantly associated either with survival (P = 0.74) or dialysis-dependency (P = 0.33).Conclusions and clinical importanceResults revealed a high prevalence of Spec cPL ≥400 μg/L in dogs with AKI treated with IHD. No significant associations between Spec cPL and survival or dialysis-dependency in dogs with AKI at 30 days were identified in the current study, however, the latter could be due to lack of power in this study
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Validation of a Clinical Scoring System for Outcome Prediction in Dogs with Acute Kidney Injury Managed by Hemodialysis.
BackgroundA scoring system for outcome prediction in dogs with acute kidney injury (AKI) recently has been developed but has not been validated.HypothesisThe scoring system previously developed for outcome prediction will accurately predict outcome in a validation cohort of dogs with AKI managed with hemodialysis.AnimalsOne hundred fifteen client-owned dogs with AKI.MethodsMedical records of dogs with AKI treated by hemodialysis between 2011 and 2015 were reviewed. Dogs were included only if all variables required to calculate the final predictive score were available, and the 30-day outcome was known. A predictive score for 3 models was calculated for each dog. Logistic regression was used to evaluate the association of the final predictive score with each model's outcome. Receiver operating curve (ROC) analyses were performed to determine sensitivity and specificity for each model based on previously established cut-off values.ResultsHigher scores for each model were associated with decreased survival probability (P < .001). Based on previously established cut-off values, 3 models (models A, B, C) were associated with sensitivities/specificities of 73/75%, 71/80%, and 75/86%, respectively, and correctly classified 74-80% of the dogs.Conclusions and clinical relevanceAll models were simple to apply and allowed outcome prediction that closely corresponded with actual outcome in an independent cohort. As expected, accuracies were slightly lower compared with those from the previously reported cohort used initially to develop the models
59Co-NMR Knight Shift of Superconducting Three-Layer NaxCoO2.yH2O
The superconducting state of NaxCoO2.yH2O with three CoO2 layers in a unit
cell has been studied by 59Co-NMR. The Knight shift measured for a peak of the
NMR spectra corresponding to the external magnetic field H along one of the
principal directions within the CoO2 plane, exhibits a rapid decrease with
decreasing temperature T below the superconducting transition temperature Tc,
indicating that the spin susceptibility is suppressed in the superconducting
phase, at least, for this field direction. Because differences of the
superconducting properties are rather small between this three-layer
NaxCoO2.yH2O and previously reported NaxCoO2.yH2O with two CoO2 layers within a
unit cell, the present result of the Knight shift studies indicates that the
Cooper pairs of the former system are in the singlet state as in the latter,
for which the spin susceptibility is suppressed for both directions of H
parallel and perpendicular to the CoO2 plane.Comment: 5 page
59Co Nuclear Quadrupole Resonance Studies of Superconducting and Non-superconducting Bilayer Water Intercalated Sodium Cobalt Oxides NaxCoO2.yH2O
We report 59Co nuclear quadrupole resonance (NQR) studies of bilayer water
intercalated sodium cobalt oxides NaxCoO2.yH2O (BLH) with the superconducting
transition temperatures, 2 K < T_c <= 4.6 K, as well as a magnetic BLH sample
without superconductivity. We obtained a magnetic phase diagram of T_c and the
magnetic ordering temperature T_M against the peak frequency nu_3 59Co NQR
transition I_z = +- 5/2 +-7/2 and found a dome shape superconducting phase.
The 59Co NQR spectrum of the non-superconducting BLH shows a broadening below
T_M without the critical divergence of 1/T_1 and 1/T_2, suggesting an
unconventional magnetic ordering. The degree of the enhancement of 1/T_1T at
low temperatures increases with the increase of nu_3 though the optimal
nu_3~12.30 MHz. In the NaxCoO2.yH2O system, the optimal-T_c superconductivity
emerges close to the magnetic instability. T_c is suppressed near the phase
boundary at nu_3~12.50 MHz, which is not a conventional magnetic quantum
critical point.Comment: 4 pages, 5 figure
Studies of the performance of different front-end systems for flat-panel multi-anode PMTs with CsI(Tl) scintillator arrays
We have studied the performance of two different types of front-end systems
for our gamma camera based on Hamamatsu H8500 (flat-panel 64 channels
multi-anode PSPMT) with a CsI(Tl) scintillator array. The array consists of 64
pixels of which corresponds to the anode pixels of
H8500. One of the system is based on commercial ASIC chips in order to readout
every anode. The others are based on resistive charge divider network between
anodes to reduce readout channels. In both systems, each pixel (6mm) was
clearly resolved by flood field irradiation of Cs. We also investigated
the energy resolution of these systems and showed the performance of the
cascade connection of resistive network between some PMTs for large area
detectors.Comment: 9 pages, 6 figures, proceedings of the 7th International Workshop on
Radiation Imaging Detectors (IWORID7), submitted to NIM
Novel phase diagram of superconductor NaxCoO2-yH2O in a 75 % relative humidity
We succeeded in synthesizing the powder samples of bilayer-hydrate sodium
cobalt oxide superconductors NaxCoO2-yH2O with Tc = 0 ~ 4.6 K by systematically
changing the keeping duration in a 75 % relative humidity atmosphere after
intercalation of water molecules. From the magnetic measurements, we found that
the one-day duration sample does not show any superconductivity down to 1.8 K,
and that the samples kept for 2 ~ 7 days show superconductivity, in which Tc
increases up to 4.6 K with increasing the duration. Tc and the superconducting
volume fraction are almost invariant between 7 days and 1month duration. The
59Co NQR spectra indicate a systematic change in the local charge distribution
on the CoO2 plane with change in duration.Comment: 4 pages, 5 figures, submitted to Journal of the Physical Society of
Japa
Development of Large area Gamma-ray Camera with GSO(Ce) Scintillator Arrays and PSPMTs
We have developed a position-sensitive scintillation camera with a large area
absorber for use as an advanced Compton gamma-ray camera. At first we tested
GSO(Ce) crystals. We compared light output from the GSO(Ce) crystals under
various conditions: the method of surface polishing, the concentration of Ce,
and co-doping Zr. As a result, we chose the GSO(Ce) crystals doped with only
0.5 mol% Ce, and its surface polished by chemical etching as the scintillator
of our camera. We also made a 1616 cm scintillation camera which
consisted of 9 position-sensitive PMTs (PSPMTs Hamamatsu flat-panel H8500), the
each of which had 88 anodes with a pitch of 6 mm and coupled to
88 arrays of pixelated 613 mm GSO(Ce) scintillators.
For the readout system of the 576 anodes of the PMTs, we used chained resistors
to reduce the number of readout channels down to 48 to reduce power
consumption. The camera has a position resolution of less than 6mm and a
typical energy resolution of 10.5% (FWHM) at 662 keV at each pixel in a large
area of 1616 cm. %to choose the best scintillator for our project.
Furthermore we constructed a 1616 array of 313 mm
pixelated GSO(Ce) scintillators, and glued it to a PMT H8500. This camera had
the position resolution of less than 3mm, over an area of 55 cm,
except for some of the edge pixels; the energy resolution was typically 13%
(FWHM) at 662 keV.Comment: Proceedings of PSD7 appear in NIM
23Na NMR study of non-superconducting double-layer hydrate NaxCoO2.yH2O
We report 23Na NMR studies of the polycrystalline samples of double-layer
hydrated cobalt oxides NaxCoO2.yH2O (x ~ 0.35 and y ~ 1.3) with the
superconducting transition temperatures Tc < 1.8K and ~4.5K, and the dehydrated
NaxCoO2 (x ~ 0.35). The hyperfine field and the electric field gradient at the
Na sites in the non-hydrated Na0.7CoO2 and the dehydrated Na0.35CoO2 are found
to be significantly reduced by the hydration, which indicates a strong
shielding effect of the intercalated water molecules on the Na sites. The
temperature dependence of 23 Na nuclear spin-lattice relaxation rate 1/23T1 of
the non-superconducting double-layer hydrate NaxCoO2.yH2O is found to be
similar to that of the non-hydrated Na0.7CoO2, whose spin dynamics is
understood by A-type (intra-layer ferromagnetic and inter-layer
antiferromagnetic) spin fluctuations. The superconducting phase is located
close to the quantum critical point with the A-type magnetic instability.Comment: 4 pages, 4 figure
Weak Magnetic Order in the Bilayered-hydrate NaCoOHO Structure Probed by Co Nuclear Quadrupole Resonance - Proposed Phase Diagram in Superconducting NaCoO HO
A weak magnetic order was found in a non-superconducting bilayered-hydrate
NaCoOHO sample by a Co Nuclear Quadrupole Resonance
(NQR) measurement. The nuclear spin-lattice relaxation rate divided by
temperature shows a prominent peak at 5.5 K, below which a Co-NQR peak
splits due to an internal field at the Co site. From analyses of the Co NQR
spectrum at 1.5 K, the internal field is evaluated to be 300 Oe and is
in the -plane. The magnitude of the internal field suggests that the
ordered moment is as small as using the hyperfine coupling
constant reported previously. It is shown that the NQR frequency
correlates with magnetic fluctuations from measurements of NQR spectra and
in various samples. The higher- sample has the stronger
magnetic fluctuations. A possible phase diagram in NaCoOHO is depicted using and , in which the crystal distortion
along the c-axis of the tilted CoO octahedron is considered to be a
physical parameter. Superconductivity with the highest is seemingly
observed in the vicinity of the magnetic phase, suggesting strongly that the
magnetic fluctuations play an important role for the occurrence of the
superconductivity.Comment: 5 pages, 6 figures, submitted to J. Phys. Soc. Jp
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