4 research outputs found
Anxiolytic Activity Evaluation Of Four Medicinal Plants From Cameroon
Afrormosia laxiflora (A. laxiflora), Chenopodium ambrosioides (C.
ambrosioides), Microglossa pyrifolia (M. pyrifolia) and Mimosa pudica
(M. pudica) are plants used in traditional medicine in Cameroon to
treat insomnia, epilepsy, anxiety, and agitation. They were evaluated
for their anxiolytic like activity in mice. Animal models (elevated
plus maze and stress-induced hyperthermia tests) were used. The four
plants showed anxiolytic activity. In stress-induced hyperthermia test,
A. laxiflora, C. ambrosioides, M. pyrifolia and M. pudica significantly
antagonised the increase of temperature. ΔT° decreased from
0.75°C in the control group to 0.36°C at the dose of 110
mg/kg for A. laxiflora; from 1°C in the control group to
-1.1°C at the dose of 120 mg/kg for C. ambrosioides; from
1.7°C in the control group to 0.2°C at the dose of 128 mg/kg
for M. pyrifolia and from 1.3°C in the control group to 0.5°C
at the dose of 180 mg/kg for M. pudica. In the elevated plus maze test,
the four plants increased the number of entries into, percentage of
entries into, and percentage of time in open arms. A. laxiflora, C.
ambrosioides and M. pudica also reduced the percentage of entries and
time in closed arms. In addition, C. ambrosioides, M. pyrifolia and M.
pudica showed antipyretic activity by reducing the body temperature.
The results suggested that C. ambrosioides, M. pyrifolia and M. pudica
posses anxiolytic-like and antipyretic activities while A. laxiflora
possesses only anxiolytic-like properties. These plants could be
helpful in the treatment of anxiety and fever in traditional medicine
in Cameroo