23 research outputs found
Efficacy and safety of TMC278 in treatment-naïve, HIV-1-infected patients with HBV/HCV co-infection enrolled in the phase III ECHO and THRIVE trials
Simultaneous quantification of lopinavir and ritonavir in human plasma by high performance liquid chromatography coupled with UV detection
Supporting Continuous Media: Is Serial Storage Architecture (SSA) Better Than SCSI?
The existing SCSI parallel bus has been widely used in supporting multimedia applications. However, it may not fully utilize the aggregate throughput from disks in supporting continuous media because of its unfair bus accesses. The emerging serial interface, Serial Storage Architecture (SSA), provides high data bandwidth, fair accesses, and fault tolerance. The fairness algorithm in SSA ensures a fraction of data bandwidth is allocated to each disk. In this paper, we study the performance of SSA and SCSI in supporting continuous media. 1 Introduction A multimedia server should guarantee continuous display of video without jitters by allocating enough network bandwidth, memory, and storage resources. Because of the high bandwidth requirements, a multimedia server must have large storage capacity, high performance I/O, and network subsystems. Even though the existing SCSI parallel bus has been widely used for most of storage subsystems, unfair accesses on an SCSI bus may hinder with su..
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Preliminary Evaluation of the Tolerance of 18 Pummelo Cultivars to Stem-Pitting Tristeza
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Relationship Between HIV Infection, Antiretroviral Therapy, Inflammatory Markers, and Cerebrovascular Endothelial Function Among Adults in Urban China
BackgroundCerebrovascular risk is increased in people living with HIV infection compared with age-matched uninfected individuals. Cerebrovascular endothelial dysfunction related to antiretroviral therapy (ART) and inflammation may contribute to higher stroke risk in HIV infection.MethodsWe compared cerebral vasoreactivity-a measure of cerebrovascular endothelial function assessed by the breath-holding index (BHI) using transcranial Doppler ultrasound-between virologically suppressed Chinese HIV-infected individuals followed in an HIV clinic in Beijing, China, and uninfected controls. We constructed mixed-effects models to evaluate the association of HIV, ART, and inflammatory markers with cerebral vasoreactivity.ResultsIn an unadjusted model, HIV infection was associated with a trend toward lower cerebral vasoreactivity (BHI 1.08 versus 1.26, P = 0.079). In multivariable analyses, cholesterol modified the association between HIV infection and cerebral vasoreactivity (P = 0.015 for interaction). At a lower total cholesterol of 4.15 mmol/L, HIV was associated with lower cerebral vasoreactivity (BHI -0.28, P = 0.019), whereas at a cholesterol of 5.15 mmol/L, the reduction in cerebral vasoreactivity associated with HIV was no longer statistically significant (BHI -0.05, P = 0.64). Among HIV-infected individuals, use of lopinavir/ritonavir compared with efavirenz was associated with lower cerebral vasoreactivity (BHI -0.24, P = 0.040). We did not find a significant association between inflammatory markers and cerebral vasoreactivity.ConclusionsCerebrovascular endothelial dysfunction associated with HIV infection may be most relevant for individuals with less traditional vascular risk, such as those with lower cholesterol. Further study of the impact of ART on cerebrovascular endothelial function is warranted to aid with ART selection in individuals at high cerebrovascular risk