Overview plots for top <i>cis</i> eQTLs.

<p>An overview of the 4 most significant <i>cis</i> eQTLs: rs11150882 with <i>C17orf97</i> (panel A), rs11158569 with <i>CHURC1</i> (panel B), rs2779212 with <i>ZSWIM7</i> (panel C) and rs2549794 with <i>ERAP2</i> (panel D). On the left of each panel, box-and-whisker plots of mRNA levels for all genotypes. On the right, mean and standard-error plots of mRNA levels for all genotypes are illustrated. Right upper corner gives the association p-value and the gene name.</p

eQTL overview plots for 4 cardiac trait GWAS candidate genes.

<p>An overview of 4 GWAS <i>cis</i> eQTLs: rs9912468 with <i>PRKCA</i> (panel A), rs7912445 with <i>GNB4</i> (panel B), rs8049607 with <i>LITAF</i> (panel C) and rs6882776 with <i>NKX2-5</i> (panel D). On the left of each panel, box-and-whisker plots of mRNA levels for all genotypes. On the right, mean and standard-error plots of mRNA levels for all genotypes are illustrated. Right upper corner gives the association p-value and the gene name.</p

Overview of the 30 most significant <i>cis</i> eQTLs, reported as independent LD-pruned SNP clusters (see Materials & Methods).

<p>The MAF and beta (effect size per copy of the minor allele) for the most significant SNP of each cluster is listed. LD  =  linkage disequilibrium, TSS  =  transcription start site, Chr.  =  chromosome.</p

Look-up of SNPs from cardiac GWAS in eQTL data.

<p>Overview of eQTL effects of reported cardiac electric trait related GWAS SNPs. Only GWAS SNPs reaching genome-wide significance as stated in the original studies (p-value ≤5×10⁻⁸) and with nominal eQTL association (p≤0.05) are reported. This resulted in 34 independent loci. <i>PRKCA</i> (<i>rs9912468</i>, QRS duration) reaches genome-wide significance (4×10⁻⁸; represented in bold in table). The beta is defined as the effect size per copy of the minor allele. LD  =  linkage disequilibrium, TSS  =  transcription start site, Chr.  =  chromosome, Y  =  yes, N  =  no.</p