2,107 research outputs found

    Antibody-Based Therapies in Multiple Myeloma

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    The unmet need for improved multiple myeloma (MM) therapy has stimulated clinical development of monoclonal antibodies (mAbs) targeting either MM cells or cells of the bone marrow (BM) microenvironment. In contrast to small-molecule inhibitors, therapeutic mAbs present the potential to specifically target tumor cells and directly induce an immune response to lyse tumor cells. Unique immune-effector mechanisms are only triggered by therapeutic mAbs but not by small molecule targeting agents. Although therapeutic murine mAbs or chimeric mAbs can cause immunogenicity, the advancement of genetic recombination for humanizing rodent mAbs has allowed large-scale production and designation of mAbs with better affinities, efficient selection, decreasing immunogenicity, and improved effector functions. These advancements of antibody engineering technologies have largely overcome the critical obstacle of antibody immunogenicity and enabled the development and subsequent Food and Drug Administration (FDA) approval of therapeutic Abs for cancer and other diseases

    Design of optimally smoothing multi-stage schemes for the Euler equations

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    Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/76080/1/AIAA-1989-1933-802.pd

    The consequences of envy and feeling envied

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    Ph.DDOCTOR OF PHILOSOPH

    Power Motivates Interpersonal Connection Following Social Exclusion

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    10.1016/j.obhdp.2013.08.006Organizational Behavior and Human Decision Processes1222257-265OBDP

    Design of optimally smoothing multistage schemes for the euler equations

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    A recently derived local preconditioning of the Euler equations is shown to be useful in developing multistage schemes suited for multigrid use. The effect of the preconditioning matrix on the spatial Euler operator is to equalize the characteristic speeds. When applied to the discretized Euler equations, the preconditioning has the effect of strongly clustering the operator's eigenvalues in the complex plane. This makes possible the development of explicit marching schemes that effectively damp most high‐frequency Fourier modes, as desired in multigrid applications. The technique is the same as developed earlier for scalar convection schemes: placement of the zeros of the amplification factor of the multistage scheme in locations where eigenvalues corresponding to high‐frequency modes abound.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/111971/1/1630081006_ftp.pd
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