Compressed Sensing and Its Application in CT and EEG

Biomedical Image Analysis and Mining Techniques for Improved Health Outcomes addresses major techniques regarding image processing as a tool for disease identification and diagnosis, as well as treatment recommendation

Medical Imaging 2015: Physics of Medical Imaging

Radiolabeled tracer distribution imaging of gamma rays using pinhole collimation is considered promising for small animal imaging. The recent availability of various radiolabeled tracers has enhanced the field of diagnostic study and is simultaneously creating demand for high resolution imaging devices. This paper presents analyses to represent the optimized parameters of a high performance pinhole array detector module using two different characteristics phantoms. Monte Carlo simulations using the Geant4 application for tomographic emission (GATE) were executed to assess the performance of a four head SPECT system incorporated with pinhole array collimators. The system is based on a pixelated array of NaI(Tl) crystals coupled to an array of position sensitive photomultiplier tubes (PSPMTs). The detector module was simulated to have 48 mm by 48 mm active area along with different pinhole apertures on a tungsten plate. The performance of this system has been evaluated using a uniform shape cylindrical water phantom along with NEMA NU-4 image quality (IQ) phantom filled with 99mTc labeled radiotracers. SPECT images were reconstructed where activity distribution is expected to be well visualized. This system offers the combination of an excellent intrinsic spatial resolution, good sensitivity and signal-to-noise ratio along with high detection efficiency over an energy range between 20-160 keV. Increasing number of heads in a stationary system configuration offers increased sensitivity at a spatial resolution similar to that obtained with the current SPECT system design with four heads. © (2015) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use onl

Design and Development of a High Performance Pinhole Array Dual Head SPECT Using Monte Carlo Simulation

The Purpose of this study is to investigate the performance of a dual head SPECT system having an array of pinholes as a collimator. Several analytical methods are used to evaluate the performance of the given pinhole array detector module design. Monte Carlo simulation studies using Geant4 Application for Tomographic Emission (GATE) validate the performance of this novel dual head SPECT where a cylindrical water phantom is imaged. We are proposing a pinhole array detector module with 48mm by 48mm of active area behind an array of 100 pinholes laid out in a 10 by 10 lattice. This configuration allows high detection efficiency and excellent sensitivity in SPECT imaging. The system is based on a pixelated array of NaI crystals (100 × 100 × 10mm elements) coupled with an array of position sensitive photomultiplier tubes (PSPMTs). The basic characteristics of this system were evaluated with pinhole apertures of 0.5mm, 1mm, 1.5mm, 2mm, 2.5mm and 3mm respectively. A conventional filtered back projection algorithm was used to reconstruct the images. Performance evaluation of this system indicates that high quality images can be obtained for in vivo imaging

Quantitative analysis of L-SPECT system for small animal brain imaging

This paper aims to investigate the performance of a newly proposed L-SPECT system for small animal brain imaging. The L-SPECT system consists of an array of 100 × 100 micro range diameter pinholes. The proposed detector module has a 48 mm by 48 mm active area and the system is based on a pixelated array of NaI crystals (10×10×10 mm elements) coupled with an array of position sensitive photomultiplier tubes (PSPMTs). The performance of this system was evaluated with pinhole radii of 50 μm, 60 μm and 100 μm. Monte Carlo simulation studies using the Geant4 Application for Tomographic Emission (GATE) software package validate the performance of this novel dual head L-SPECT system where a geometric mouse phantom is used to investigate its performance. All SPECT data were obtained using 120 projection views from 0° to 360° with a 3° step. Slices were reconstructed using conventional filtered back projection (FBP) algorithm. We have evaluated the quality of the images in terms of spatial resolution (FWHM) based on line spread function, the system sensitivity, the point source response function and the image quality. The sensitivity of our newly proposed L- SPECT system was about 4500 cps/μCi at 6 cm along with excellent full width at half-maximum (FWHM) using 50 μm pinhole aperture at several radii of rotation. The analysis results show the combination of excellent spatial resolution and high detection efficiency over an energy range between 20-160 keV. The results demonstrate that SPECT imaging using a pixelated L-SPECT detector module is applicable in a quantitative study of mouse brain imaging. © (2016) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only