Compressed Sensing and Its Application in CT and EEG

Biomedical Image Analysis and Mining Techniques for Improved Health Outcomes addresses major techniques regarding image processing as a tool for disease identification and diagnosis, as well as treatment recommendation

Medical Imaging 2015: Physics of Medical Imaging

Radiolabeled tracer distribution imaging of gamma rays using pinhole collimation is considered promising for small animal imaging. The recent availability of various radiolabeled tracers has enhanced the field of diagnostic study and is simultaneously creating demand for high resolution imaging devices. This paper presents analyses to represent the optimized parameters of a high performance pinhole array detector module using two different characteristics phantoms. Monte Carlo simulations using the Geant4 application for tomographic emission (GATE) were executed to assess the performance of a four head SPECT system incorporated with pinhole array collimators. The system is based on a pixelated array of NaI(Tl) crystals coupled to an array of position sensitive photomultiplier tubes (PSPMTs). The detector module was simulated to have 48 mm by 48 mm active area along with different pinhole apertures on a tungsten plate. The performance of this system has been evaluated using a uniform shape cylindrical water phantom along with NEMA NU-4 image quality (IQ) phantom filled with 99mTc labeled radiotracers. SPECT images were reconstructed where activity distribution is expected to be well visualized. This system offers the combination of an excellent intrinsic spatial resolution, good sensitivity and signal-to-noise ratio along with high detection efficiency over an energy range between 20-160 keV. Increasing number of heads in a stationary system configuration offers increased sensitivity at a spatial resolution similar to that obtained with the current SPECT system design with four heads. © (2015) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use onl

Quantitative analysis of L-SPECT system for small animal brain imaging

This paper aims to investigate the performance of a newly proposed L-SPECT system for small animal brain imaging. The L-SPECT system consists of an array of 100 × 100 micro range diameter pinholes. The proposed detector module has a 48 mm by 48 mm active area and the system is based on a pixelated array of NaI crystals (10×10×10 mm elements) coupled with an array of position sensitive photomultiplier tubes (PSPMTs). The performance of this system was evaluated with pinhole radii of 50 μm, 60 μm and 100 μm. Monte Carlo simulation studies using the Geant4 Application for Tomographic Emission (GATE) software package validate the performance of this novel dual head L-SPECT system where a geometric mouse phantom is used to investigate its performance. All SPECT data were obtained using 120 projection views from 0° to 360° with a 3° step. Slices were reconstructed using conventional filtered back projection (FBP) algorithm. We have evaluated the quality of the images in terms of spatial resolution (FWHM) based on line spread function, the system sensitivity, the point source response function and the image quality. The sensitivity of our newly proposed L- SPECT system was about 4500 cps/μCi at 6 cm along with excellent full width at half-maximum (FWHM) using 50 μm pinhole aperture at several radii of rotation. The analysis results show the combination of excellent spatial resolution and high detection efficiency over an energy range between 20-160 keV. The results demonstrate that SPECT imaging using a pixelated L-SPECT detector module is applicable in a quantitative study of mouse brain imaging. © (2016) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only

Performance Evaluation of a Newly Proposed Novel L-SPECT System for SPECT Imaging

The importance of pre-clinical research of singlephoton emission computed tomography (SPECT) imaging is nowwidely recognized. For the demand of high resolution and highdetection efficiency, SPECT has been developed in several waysand it is simultaneously making demand for high qualityimaging. This paper introduces the newly proposed dual-head LSPECTsystem and investigates the initial performance of thesystem having an array of pinholes as a collimator. The proposedL-SPECT system is based on the concept of light field imagingallowing the refocusing of images after exposure. A microlensarray is placed just before the imaging sensor to simultaneouslyrecord the direction of incident light rays and their intensities.We are proposing a detector module with 48mm by 48mm ofactive area behind an array of 100×100 pinholes for gamma raysinstead of microlenses. The system is based on a pixelated arrayof NaI crystals (10×10×10 mm elements) coupled with an array ofposition sensitive photomultiplier tubes (PSPMTs). The basiccharacteristics of this system were evaluated with pinhole radii of50µm, 60µm and 100µm. The measurements of system sensitivity,system spatial resolution, energy resolution, volume sensitivityand uniformity were evaluated for 99mTc (140keV) solution wherereconstructed images are well visualized. Monte Carlo simulationstudies using the Geant4 Application for Tomographic Emission(GATE) software package validate the performance of this noveldual head L-SPECT where a general cylindrical water phantomis used to evaluate its performance. The analysis results show thecombination of excellent spatial resolution and high detectionefficiency over an energy range between 20-160 keV