1 research outputs found
The use of J-coupling as a sole criterion to assign the total absolute stereochemistry of new pyrrolidinone class synthetic analogs, derived from S-pyroglutamic acid
During the synthesis of new pyrrolidinone analogs possessing biological activity it is intriguing to assign
their absolute stereochemistry as it is well known that drug potency is influenced by the stereochemistry. The combination of J-coupling information with theoretical results was used in order to establish
their total stereochemistry when the chiral center of the starting material has known absolute stereochemistry. The J-coupling can be used as a sole criterion for novel synthetic analogs to identify the right
stereochemistry. This approach is extremely useful especially in the case of analogs whose 2D NOESY
spectra cannot provide this information. Few synthetic examples are given to prove the significance of
this approach