The Analysis of Students' Psychological Problems and Its Solutions in Speaking English at One of the Junior High Schools in Aru Islands

and their solutions in speaking English. The research design of this study was a mixed method with an explanatory sequential design approach. The population of this study was second-grade students, and its sample was two classes consisting of 60 students and 3 English teachers who taught them. The instruments used in this study were questionnaires and interviews. The quantitative data were analyzed using the formula from Sugiyono (2005) f/n x 100%, while the qualitative data was analyzed using the technique by Miles and Huberman (1992:16) data reduction, data display, and conclusion drawing/verifying. The results of this study indicate that students still have problems speaking English, especially psychological problems such as fear of making mistakes, lack of self-confidence, lack of motivation, and anxiety. Therefore, based on the problems above, there are several solutions provided by teachers and students to overcome these problems

KAJIAN DAN DESAIN TOURISM MARKETING di NEGERI OMA ; PROFIL DAN PEMETAAN (PENELITIAN TERAPAN TAHUN I)

The tourism sector is a service sector that contributes significantly financially to the country's economy. Maluku province has tourism potential. Including a tourist attraction in Oma village, one of the villages in Central Maluku district, Ambon City, Maluku Province. This research is a multi-year study (4 years) and aims to: 1. create a profile and mapping of tourist objects, 2. create easy access and facilities, 3. implement integrated marketing communications and digitization of tourism marketing and 4. collaborate on tourism marketing in Oma village with Maluku tourism & investment industry. For the first year of research, the research objective is number 1, which is to create a profile and mapping of tourist objects in Oma's Country. This type of research is applied research and qualitative methods

Characterization of chemokine and cytokine expression pattern in tuberculous lymphadenitis patient

Introduction: C-C chemokine receptor-2 (CCR-2) and C-C chemokine ligand-5 (CCL-5) play an important role in the migration of monocytes, macrophages, dendritic cells, and activated T cells against Mycobacterium tuberculosis (M.tb). Meanwhile, signal transducer and activator of transcription 3 (STAT-3) and suppressor of cytokine signaling 3 (SOCS-3), activated by interleukin (IL)-6 and IL-10 in tuberculosis (TB) infection, play an important role in phagocytosis, inflammation, and granulomatous-forming processes that may lead to TB treatment success or failure. However, there are no data about the expression of those markers in tuberculous lymphadenitis. The characterization of those markers is very critical to put a fundamental basis to understand the homing mechanism of tuberculous lymphadenitis. Aim of study: The specific objective of this study is to characterize the expression pattern of CCR-2-CCL-5, IL-6, IL-10, STAT-3, and SOCS-3 in tuberculous lymphadenitis. Methods: The study was performed on 27 cases of tuberculous lymphadenitis node biopsies. The diagnosis of tuberculous lymphadenitis was based on the clinical criteria and the presence of the histological feature characteristic of TB granulomas. Afterward, immunohistochemistry was stained with CCR-2, CCL-5, IL-6, IL-10, STAT-3, and SOCS-3. A semiquantitative analysis of IHC images was performed to examine protein expression in stained preparations. The expression was also manually counted. Results: Compared with the normal area, both lymphocytes and macrophages expressed strongly CCR-2-, CCL-5, and IL-6, while IL-10, STAT-3-, and SOCS-3- were expressed lowly. There was a strong positive correlation between CCR-2 with IL-6 (p = 0,83) and IL-10 (p = 0,83). Conclusion: The chronic infection process of tuberculous lymphadenitis was characterized by the expression of IL-10low, STAT-3low, SOCS-3low, CCR-2high, CCL-5high, and IL-6high. Clinical Trial Registration: Clinicaltrials.gov, identifier NCT05202548