Cyber-Physical Systems: A Model-Based Approach

In this concise yet comprehensive Open Access textbook, future inventors are introduced to the key concepts of Cyber-Physical Systems (CPS). Using modeling as a way to develop deeper understanding of the computational and physical components of these systems, one can express new designs in a way that facilitates their simulation, visualization, and analysis. Concepts are introduced in a cross-disciplinary way. Leveraging hybrid (continuous/discrete) systems as a unifying framework and Acumen as a modeling environment, the book bridges the conceptual gap in modeling skills needed for physical systems on the one hand and computational systems on the other. In doing so, the book gives the reader the modeling and design skills they need to build smart, IT-enabled products. Starting with a look at various examples and characteristics of Cyber-Physical Systems, the book progresses to explain how the area brings together several previously distinct ones such as Embedded Systems, Control Theory, and Mechatronics. Featuring a simulation-based project that focuses on a robotics problem (how to design a robot that can play ping-pong) as a useful example of a CPS domain, Cyber-Physical Systems: A Model-Based Approach demonstrates the intimate coupling between cyber and physical components, and how designing robots reveals several non-trivial control problems, significant embedded and real-time computation requirements, and a need to consider issues of communication and preconceptions

Cyber-Physical Systems: A Model-Based Approach

In this concise yet comprehensive Open Access textbook, future inventors are introduced to the key concepts of Cyber-Physical Systems (CPS). Using modeling as a way to develop deeper understanding of the computational and physical components of these systems, one can express new designs in a way that facilitates their simulation, visualization, and analysis. Concepts are introduced in a cross-disciplinary way. Leveraging hybrid (continuous/discrete) systems as a unifying framework and Acumen as a modeling environment, the book bridges the conceptual gap in modeling skills needed for physical systems on the one hand and computational systems on the other. In doing so, the book gives the reader the modeling and design skills they need to build smart, IT-enabled products. Starting with a look at various examples and characteristics of Cyber-Physical Systems, the book progresses to explain how the area brings together several previously distinct ones such as Embedded Systems, Control Theory, and Mechatronics. Featuring a simulation-based project that focuses on a robotics problem (how to design a robot that can play ping-pong) as a useful example of a CPS domain, Cyber-Physical Systems: A Model-Based Approach demonstrates the intimate coupling between cyber and physical components, and how designing robots reveals several non-trivial control problems, significant embedded and real-time computation requirements, and a need to consider issues of communication and preconceptions

Histopathological and immunohistochemical study of the protective effect of triptorelin on the neurocytes of the hippocampus and the cerebral cortex of male albino rats after short-term exposure to cyclophosphamide

AbstractChemotherapy treats many types of cancer effectively but it often causes side effects. Chemotherapy works on active cells, such as cancer cells, and some healthy cells. Side effects happen when chemotherapy damages these healthy cells. Today, many more drugs are available to treat side effects than in the past. Triptorelin (Decapeptyl) is a gonadotropin-releasing hormone agonist that is reported to have many therapeutic effects besides being an anti-cancer agent. In the current study, intraperitoneal cyclophosphamide (65mg/kg/day) was administered for 4 weeks to induce marked dystrophic changes in the cerebral cortex and hippocampus of male albino rats. After 4 weeks, we observed significant degeneration of neurocytes with dystrophic changes. Subcutaneous triptorelin (0.05mg/kg/day) for 4 weeks significantly improved histological signs of degeneration and apoptosis. Anti-Bcl2 staining of sections of the cerebral cortex and hippocampus showed that the apoptotic index was increased. This finding was confirmed by the anti-p53 staining, which showed a significant decrease in the apoptotic index. Ultimately, such improvements were accompanied by significant restoration of normal brain histology, as revealed by hematoxylin and eosin. In conclusion, triptorelin can reverse the apoptotic changes induced by cyclophosphamide therapy, which is more marked in the hippocampus than cerebral cortex

Leveraging the Force of Formative Assessment & Feedback for Effective Engineering Education

In recent years, there has been a fundamental shift in engineering education from an emphasis on covering content to a student-centric focus on ensuring the attainment of learning outcomes. To ensure attainment of the educational objectives, engineering education thought leaders have highlighted the importance of the development of effective authentic assessment schemes appropriate for the 21st century, and the alignment of assessment and instructional efforts with the planned learning objectives and outcomes. Our focus in this paper is on the use of formative assessment (also called assessment for learning) for engineering education. With formative assessment, an assessment is made of the current learning level and then pertinent feedback is provided to both the student and to the instructor so that they can take concrete steps to facilitate learning improvement. This is in contrast with the ubiquitous summative feedback (assessment ``of'' learning)---in which the main aim is to grade or rank the student by ascertaining their current learning level without really giving them concrete advice on what to do next to improve learning performance. The use of formative assessment can transform students' performance by empowering them with particularly potent ``self-assessment’’ skills through which students become more aware of their learning and know what is it that they should do next (i.e., they become ``self-directed”.) Formative assessment is equally useful for the teaching staff—by helping them know their impact and tailor the instructional strategy and try to personalize their pedagogy to the individual needs of the students. The main contributions of our paper are that we review the rich literature on formative assessment and effective feedback and synthesize insights that are relevant for engineering education

Outcome-Based Engineering Education: A Global Report of International OBE Accreditation and Assessment Practices

Outcome-based education (OBE) is a paradigm in which instructional and assessment/ evaluation are explicitly designed for ensuring the attainment and mastery of predefined learning outcomes. OBE is now the underlying paradigm followed by global accreditation efforts such as the Washington Accord (ratified in 1989). The shift to OBE is so pronounced that some education experts identify the shift to outcome-based education and accreditation as one of the top 5 major changes of the last 100 years. OBE is starkly different from the previous content-based educational approaches in shifting the aim from covering the content to a student-centric mastery that is driven by exit-outcomes and educational objectives. And while OBE is often criticized for straitjacketing education, and resisted by hesitant faculty members suspecting additional burden, studies show that the OBE movement, on the whole, has helped in improving the educational standards and outcomes by helping ensure proper planning of curriculum and assessment and their alignment with the program objectives and desired outcomes. OBE is also flexible in the sense that it does not dictate the choice of specific education strategies or teaching methods. New OBE schemes have also diversified in response to early misgiving about OBE (related to excessive paperwork, and bean-counting-like auditing) and now admit diverse types of evidence (including qualitative and quantitative, formative and summative, formal and informal assessments). In this paper, we present—as a geographically dispersed set of academics from Pakistan, United Kingdom, United States of America, Malaysia, Saudi Arabia—a global international perspective on OBE accreditation standards, practices, and attitudes. We will trace the historical development leading to the great shift to OBE in recent times and also synthesize insights from our diverse transnational experience in meeting accreditation requirements in different countries

Quality of Experience in 6G Networks: Outlook and Challenges

In this paper, we discuss the critical characteristics of user experience in sixth generation (6G) cellular networks. We first describe cellular networks’ evolution through 5G and then discuss the enabling technologies and projected services in 6G networks. We note that these networks are markedly centered around expanded intelligence, end-to-end resource and topology synchronization, and the intrinsic support to low-latency, high-bandwidth communication. These capabilities make context-rich, cyberphysical user experiences viable. It thereby becomes necessary to define and identify the role of quality of experience in 6G networks, especially when it comes to network management. We elaborate on these expected challenges and allude to viable opportunities in emerging technologies

An IoT Architecture for Assessing Road Safety in Smart Cities

The Safe System (SS) approach to road safety emphasizes safety-by-design through ensuring safe vehicles, road networks, and road users. With a strong motivation from the World Health Organization (WHO), this approach is increasingly adopted worldwide. Considerations in SS, however, are made for the medium-to-long term. Our interest in this work is to complement the approach with a short-to-medium term dynamic assessment of road safety. Toward this end, we introduce a novel, cost-effective Internet of Things (IoT) architecture that facilitates the realization of a robust and dynamic computational core in assessing the safety of a road network and its elements. In doing so, we introduce a new, meaningful, and scalable metric for assessing road safety. We also showcase the use of machine learning in the design of the metric computation core through a novel application of Hidden Markov Models (HMMs). Finally, the impact of the proposed architecture is demonstrated through an application to safety-based route planning

Modeling Mobility for Networked Mobile Cyber-Physical Systems

ABSTRACT Simulation plays a considerable role in validating CyberPhysical Systems (CPSs) as it substantially reduces the costs and risks in the design-testing cycles. Reliable simulations, however, mandate realistic modeling for both the cyber and the physical aspects. This is especially the case in various networked mobile CPSs (e.g., excavation robots and vehicular networks), where costs and risks may become substantial. Our interest in this work is to briefly survey how mobility is modeled in state-of-the-art network simulators. The survey considers representative models commonly used in the literature, their enhancements, and their persisting limitations. It also reports on some recent attempts to integrate network simulators with physical modeling environments