The Grizzly, March 16, 2023

Dean Schneider to Leave Ursinus: Announcement Raises Questions for Many Faculty Members • Maker\u27s Club Promises Creative Fun for All Majors • Anarchy at Ursinus? • Meet the New President, Alisa Zenchenko \u2725 • Softball Season Back in Session • What Will Seniors Be Doing After Graduation? • Ursinus Spring Break Wrap-Up • Mayhem Defends the Intramural Basketball Den • Serving...in Floridahttps://digitalcommons.ursinus.edu/grizzlynews/2008/thumbnail.jp

The Grizzly, February 17, 2022

Happy Birthday, Ursinus! • Michael Green, Man Around Campus • The Search for a New English Professor • Movies With the Melrose Fellows • Ursinus Bucket List Challenge • D3 Dreamin\u27: The Tyler Neal Story • 1,000 Points for Ryan Hugheshttps://digitalcommons.ursinus.edu/grizzlynews/1979/thumbnail.jp

The Grizzly, April 13, 2023

Photo Essay: Spring Has Sprung! • Escape Velocity: Avenge [ance] in the Air • Ursinus Installs New Sustainable Rain Garden • GSA: Creating a Safe Space on Campus • Senior Honors Projects • Opinions: What Renovations Do You Want to See in Lower Wismer? • Playing Ball Like a Girl • Raising the Bar : Ursinus College Women\u27s Lacrosse Teamhttps://digitalcommons.ursinus.edu/grizzlynews/2012/thumbnail.jp

The Grizzly, November 18, 2021

Ursinus College Democrats Making a Comeback • Bears Frightened Bullets • Bears Bring in Bucks for #Giving2UCDay • The Re Mark able Feinberg • Exchanging Sticks for Cameras • Opinions: A Spooky Homecoming; Life After Ursinus: What Will I Do? • SAAC\u27s Spicy Spirit Week • Women\u27s Soccer Final Kickhttps://digitalcommons.ursinus.edu/grizzlynews/1974/thumbnail.jp

Reprogramming alveolar macrophage responses to TGF-β reveals CCR2+ monocyte activity that promotes bronchiolitis obliterans syndrome

Bronchiolitis obliterans syndrome (BOS) is a major impediment to lung transplant survival and is generally resistant to medical therapy. Extracorporeal photophoresis (ECP) is an immunomodulatory therapy that shows promise in stabilizing BOS patients, but its mechanisms of action are unclear. In a mouse lung transplant model, we show that ECP blunts alloimmune responses and inhibits BOS through lowering airway TGF-β bioavailability without altering its expression. Surprisingly, ECP-treated leukocytes were primarily engulfed by alveolar macrophages (AMs), which were reprogrammed to become less responsive to TGF-β and reduce TGF-β bioavailability through secretion of the TGF-β antagonist decorin. In untreated recipients, high airway TGF-β activity stimulated AMs to express CCL2, leading to CCR2+ monocyte-driven BOS development. Moreover, we found TGF-β receptor 2-dependent differentiation of CCR2+ monocytes was required for the generation of monocyte-derived AMs, which in turn promoted BOS by expanding tissue-resident memory CD8+ T cells that inflicted airway injury through Blimp-1-mediated granzyme B expression. Thus, through studying the effects of ECP, we have identified an AM functional plasticity that controls a TGF-β-dependent network that couples CCR2+ monocyte recruitment and differentiation to alloimmunity and BOS

Meeting the cultural and service needs of Arabic international students by using QFD

Quality has become an important factor in global competition for many reasons. Intensive global competition and the demand for better quality by customers has led organizations to realize the benefits of providing quality products and services in order to successfully compete and survive. Higher education institutions are one example of these organisations. Higher education institutions work in an intensive competitive environment worldwide driven by increasing demands for learning by local and international students. As a result, the managers of these sectors have realized that improving the quality of services is important for achieving customer satisfaction which can help survival in an internationally competitive market. To do this, it is necessary for organizations to know their customers and identify their requirements. To this end, many higher education institutions have adopted principles of total quality management (TQM) to improve their education quality which leads to better performance through involvement of every department to achieve excellence in business. This chapter considers the importance of measuring quality in order to assist universities to proactively manage the design and improvement of the social and academic experiences of postgraduate international students, and plan management decision-making processes to deliver high-quality services in a globalized business of provision of higher education. Higher education institutions must operate effectively and efficiently and be able to deliver quality programs, by seeking to better understand the needs of their customers to be competitive in this market space

BioEarth: Envisioning and developing a new regional earth system model to inform natural and agricultural resource management

As managers of agricultural and natural resources are confronted with uncertainties in global change impacts, the complexities associated with the interconnected cycling of nitrogen, carbon, and water present daunting management challenges. Existing models provide detailed information on specific sub-systems (e.g., land, air, water, and economics). An increasing awareness of the unintended consequences of management decisions resulting from interconnectedness of these sub-systems, however, necessitates coupled regional earth system models (EaSMs). Decision makers’ needs and priorities can be integrated into the model design and development processes to enhance decision-making relevance and “usability” of EaSMs. BioEarth is a research initiative currently under development with a focus on the U.S. Pacific Northwest region that explores the coupling of multiple stand-alone EaSMs to generate usable information for resource decision-making. Direct engagement between model developers and non-academic stakeholders involved in resource and environmental management decisions throughout the model development process is a critical component of this effort. BioEarth utilizes a bottom-up approach for its land surface model that preserves fine spatial-scale sensitivities and lateral hydrologic connectivity, which makes it unique among many regional EaSMs. This paper describes the BioEarth initiative and highlights opportunities and challenges associated with coupling multiple stand-alone models to generate usable information for agricultural and natural resource decision-making