7 research outputs found

    The Lancet Psychiatry Commission on intimate partner violence and mental health : advancing mental health services, research, and policy

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    Intimate partner violence (IPV) is the most common form of violence worldwide and contributes significantly to the global burden of mental health problems. The Lancet Psychiatry Commission on Intimate Partner Violence and Mental Health met to consider progress in reducing IPV and its associated mental health harms (see panel 1), and to establish a roadmap for strengthening responses across mental health research, services, and policy. Mental health care is delivered predominantly through primary care globally, but to date the relationship between IPV and severe mental health problems, and how to address IPV within secondary mental health care, has been relatively neglected. We therefore focus mainly on the changes needed to address IPV within secondary mental health care. Our focus on mental health is pragmatic rather than exclusionary: we also recognise the need for broader change across multiple disciplines, systems, and institutions

    Neutrophils in Cystic Fibrosis Display a Distinct Gene Expression Pattern

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    We compared gene expression in blood neutrophils (polymorphonuclear leukocytes, or PMNs) collected from healthy subjects with those of cystic fibrosis (CF) patients devoid of bacterial colonization. Macroarray analysis of 1050 genes revealed upregulation of 62 genes and downregulation expression of 27 genes in CF blood PMNs. Among upregulated genes were those coding for vitronectin, some chemokines (particularly CCL17 and CCL18), some interleukin (IL) receptors (IL-3, IL-8, IL-10, IL-12), all three colony-stimulating factors (G-, M-, GM-CSF), numerous genes coding for molecules involved in signal transduction, and a few genes under the control of γ-interferon. In contrast, none of the genes coding for adhesion molecules were modulated. The upregulation of six genes in CF PMNs (coding for thrombospondin-1, G-CSF, CXCL10, CCL17, IKKɛ, IL-10Ra) was further confirmed by qPCR. In addition, the increased presence of G-CSF, CCL17, and CXCL10 was confirmed by ELISA in supernatants of neutrophils from CF patients. When comparison was performed between blood and airway PMNs of CF patients, there was a limited difference in terms of gene expression. Only the mRNA expression of amphiregulin and tumor necrosis factor (TNF) receptor p55 were significantly higher in airway PMNs. The presence of amphiregulin was confirmed by ELISA in the sputum of CF patients, suggesting for the first time a role of amphiregulin in cystic fibrosis. Altogether, this study clearly demonstrates that blood PMNs from CF patients display a profound modification of gene expression profile associated with the disease, suggesting a state of activation of these cells
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